Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Promotor: Prof.dr. J. Kuiper

Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

Groeiende gezondheidsverschillen, toenemende zorgkosten, de vergrijzing en het tekort aan zorgpersoneel zijn slechts enkele voorbeelden van uitdagingen waar de gezondheidszorg voor staat, zowel in Nederland als daarbuiten. Deze vraagstukken overstijgen de grenzen van de medische sector en raken aan…

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

The aim is to develop methods to assess environmental and occupational exposure to (individual) pesticides, to be applied in epidemiological studies investigating pesticide exposure and human health. Furthermore, we aim to investigate the potential association between exposure to pesticides and Parkinson’s…

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.

Promotor: J. Kuiper

The majority (80%) of e-waste generated globally are recycled informally in developing countries.

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.

In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

Promotor: Prof.dr. R.M.H. Merks

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

Promotie

Promotor: Prof.dr. J.N. Kok, Co-promotor: A.J. Knobbe

Het Leiden Leadership Centre werkt samen met de onderzoeksgroep Population Health Governance (LUMC-Campus Den Haag) op onderwerpen die raken aan governance en leiderschap in de zorg. Deze onderzoeksgroep is onderdeel van het stimuleringsgebied Population Health van de Universiteit Leiden. Onder de eerste…

De hedendaagse gezondheidszorg staat voor vele uitdagingen. De nieuwe interdisciplinaire master PHM leidt je in twee jaar op om een bijdrage te kunnen leveren aan een meer geïntegreerd gezondheidszorgsysteem.

The different kinds of cultural perspectives on health and disease of the participants are related to their knowledge, beliefs, values and practices manifested in various forms of lifestyle in Indonesia. The cultural diversity of the population is also related to differences in health behaviour.

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Studievoorlichting

Studievoorlichting

Wiskunde en Natuurwetenschappen

Psycholoog Bernadet Klaassens heeft een groot fMRI-onderzoek opgezet naar het effect van medicijnen op hersennetwerken bij veroudering en de ziekte van Alzheimer. Het leverde een unieke dataset op en zicht op een nieuwe methode om medicijnen te ontwikkelen voor patiënten met Alzheimer.

De masteropleiding Health, Ageing and Society bereid studenten voor op een betekenisvolle rol in het verbeteren van de kwaliteit van leven van ouderen, en de kwaliteit en organisatie van de zorg voor een verouderende samenleving. Onze studenten voelen zich sterk betrokken bij maatschappelijke vraagstukken…

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

Studievoorlichting

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

Current therapies for patients with atherosclerosis are targeted primarily on reducing blood cholesterol, but this fails to prevent a large number of cardiovascular events.95 In order to identify new therapeutic strategies for treating atherosclerosis, it is important to study the interactions between…

This study has been carried out in the community of Sukamiskin, a kelurahan (‘village’) in Bandung, the Capital of West Java Province, located in the Sunda Region of Indonesia.

Op 21 november 2018 verdedigde Lieke Kools haar proefschrift 'Essays on wealth, health, and data collection'. Het promotieonderzoek is begeleid door promotoren prof. dr. K.P. Goudswaard en prof. dr. C.L.J. Caminada.

Promotores: H.A. Udo De Haes, P.M. Brakefield

Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…

Dit boek onderzoekt hoe zorgen over de volksgezondheid en politieke agenda’s elkaar in de VS de afgelopen eeuw hebben beïnvloed.

Promotie