In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

GLOBOX is a spatially differentiated multimedia fate, exposure and effect model. It is used for the calculation of spatially differentiated LCA characterisation factors on a global scale.

Shabaz Sultan en Simon Portegies Zwart, met de hulp van Vincent Icke, hebben één van de tien Surf Innovation Challenge Awards gewonnen voor hun onderzoek naar 'Interactive high-performance laboratory for Chaos'. De winnaars hebben een geldprijs van 10.000 euro ontvangen en krijgen 6 maanden (tot 1 juni…

The Standard Model (SM) of particle physics fails to explain several observed phenomena and is incomplete. In order to resolve this problem, one may extend the SM by adding new particles.

The ultimate goal of cosmologists is to find a cosmological model able to explain the current observational data.

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M. Bongards (Cologne University)

The ReCiPe methodology for Life Cycle Impact Assessment (LCIA).

Promotor: F.P. Israel, Co-Promoter: R. Meijerink

Promotor: Prof.dr. M.L. van Heck, Co-Promotor: B.P. Tighe

What happens to electrical waves that have to cross gaps in insulation material around nerves in the human body

This thesis discusses the discovery potential of Intensity Frontier experiments.

This thesis consists of five chapters on how to construct prediction sets for different types of data and models in a parametric or nonparametric Bayesian paradigm.

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

A critical look at the impact assessment modelling of metals in Life Cycle Impact Assessment and improvement options.

De onderzoeksgroep Digital Archaeology beheert twee computerlaboratoria voor verschillende doeleinden: een onderwijslab en een onderzoekslab.

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This thesis is comprised of three chapters covering the theme of studying semistable varieties by looking at their dual combinatorial objects.

It is an established fact that the Standard Model has to be extended to explain the so-called Beyond the Standard Model (BSM) phenomena: dark matter, matter-antimatter asymmetry of the Universe and neutrino flavour oscillations.

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

In this dissertation non-parametric Bayesian methods are used in the application of robotic vision.

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

In this work, we attempt to answer the question:

Promotor: A. Achúcarro, Co-promotor: A. Boyarsky

Promotor: J. N. Kok, Co-promotor: A. J. Knobbe

Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.

A dense region of a gaseous and dusty cloud collapses to form a protostar surrounded by a disk and an envelope. This thesis uses both observations and models to study physical and chemical conditions of these protostellar systems which are likely where planets start to form.

In het Scheepvaartmuseum van Amsterdam bevindt zich een getuigd model van een driemasterschip uit de tweede helft van de zestiende eeuw: het oudste scheepsmodel in de museumcollectie. Historicus Louis Sicking deed in opdracht van het museum onderzoek naar dit bijzondere object.

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.

Promotors: Prof.dr. J. Zaanen, Prof.dr.ir. H. Hilgenkamp

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Hoe bepaal je bij een kind de juiste dosering van een medicijn? Dat kan niet altijd op basis van lichaamsgewicht. Maar soms kan dat wèl, ontdekte farmacoloog Elke Krekels. Ze won hiermee de TOP-Publicatieprijs van de Nederlandse Vereniging voor Klinische Farmacologie en Biofarmacie. In de uitzending…

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Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Artificial intelligence algorithms govern in subtle, yet fundamental ways, the way we live and are transforming our societies. The promise of efficient, low‐cost or ‘neutral’ solutions harnessing the potential of big data has led public bodies to adopt algorithmic systems in the provision of public…