414 zoekresultaten voor “novel prize” in de Publieke website
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Novel pharmacometric techniques to quantify the pharmacodynamics of analgesics
The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.
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Identification of novel targets in prostate cancer progression
Promotor: B. van de Water, Co-promotor: E.H.J. Danen
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Exploring the mechanisms of metastatic onset for novel treatment strategies
This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.
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Novel regulators of prostate cancer stem cells and tumor aggressiveness
Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm
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Novel analytical approaches to characterize particles in biopharmaceuticals
Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).
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Immunity in atherosclerosis: novel assays, biomarkers and therapeutic approaches
Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.
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Modelling the interactions of advanced micro- and nanoparticles with novel entities
Novel entities may pose risks to humans and the environment. The small particle size and relatively large surface area of micro- and nanoparticles (MNPs) make them capable of adsorbing other novel entities, leading to the formation of aggregated contamination.
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Manipulating carbon nanotubes Towards the application as novel field emission sources
Promotores: T.H. Oosterkamp, N. de Jonge
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From every angle: novel insights into CC chemokine receptor 2 pharmacology
The CC chemokine receptor 2 (CCR2), a member of the G protein-coupled receptor (GPCR) superfamily, is widely involved in autoimmune and inflammatory diseases. However, no drugs for this receptor have made it to the pharmaceutical market yet.
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The road to insurmountability: Novel avenues to better target CC Chemokine receptors
This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.
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Discovery of novel Antibiotics from Actinomycetes by Integrated Metabolomics & Genomics Approaches
Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
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Knowledge discovery from patient forums: gaining novel medical insights from patient experiences
Patients share valuable advice and experiences with their peers in online patient discussion groups.
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Witnessing the Process of Bacterial Cell Death: Novel Antimicrobials and Their Mechanisms of Action
This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…
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Discovery of novel inhibitors to investigate diacylglycerol lipases and α/β hydrolase domain 16A
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Visualizing strongly-correlated electrons with a novel scanning tunneling microscope
Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.
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Novel analytical approaches for the characterization of cell-based medicinal products and their formulation
Cell-based medicinal products (CBMPs), such as CAR T cells, are highly complex biopharmaceutical products offering various treatment options for serious illnesses such as cancer or autoimmune diseases.
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Prediction of spatial-temporal brain drug distribution with a novel mathematical model
A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.
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Probing quantum materials with novel scanning tunneling microscopy techniques
This thesis described the development of novel scanning tunneling microscopy techniques to investigate strongly correlated electronic states in quantum matter.
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Novel Immune Cell-Based Therapies for Atherosclerosis
Promotor: Prof.dr. J. Kuiper
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Novel detectors and algorithms for electron nano-crystallography
Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel
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Novel approaches for direct exoplanet imaging: theory, simulations and experiments
The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.
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Novel Protecting Group Strategies in the Synthesis of Oligosaccharides
The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.
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Thermostable Nanodiscs for the development of novel biopharmaceuticals
Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…
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Identifying novel genetic causes of familial colorectal cancer
Promotie
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Boyd Leupen wint MSc Thesis Prize 2015
Boyd Leupen heeft de MSc Thesis Prize 2015 gewonnen. Met ‘Refuting asymmetrical Kantianism: On the moral standing of animals’ rondt Leupen zijn Masteropleiding Political Science af en levert hij een waardevolle bijdrage aan de politieke filosofie. Volgens de jury onderscheidde Leupens masterscriptie…
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Haldane Prize 2013 voor Dimiter Toshkov
Dimiter Toshkov, universitair docent bij het instituut Bestuurskunde, is een van de twee prijwinnaars van de Haldane Prize.
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To affinity and beyond: novel molecular tools to explore solute carrier transport proteins
Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.
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A novel formulation for skin barrier repair : from ex vivo assessment towards clinical studies
The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.
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Zebrafish xenograft model: identification of novel mechanisms driving prostate cancer metastasis
Prostate cancer (PCa) is one of the most prevalent cancer in males.
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Genomics driven metabolomics novel strategies for the discovery and identification of secondary metabolites
Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken
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Novel factors modulating AGC kinase signaling-controlled polar auxin transport
The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.
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Exploring novel regulators and enzymes in salicylic acid-mediated plant defense
Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.
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Novel formulations and delivery strategies for inactivated polio vaccines : new routes with benefits
This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.
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Versatility of Human β-Glucosidases and Related Glycosylated Metabolites with Novel Chemical Tools
Thesis focused on uncovering the underlying mechanisms of the lysosomal storage disorders Gaucher's disease using chemical tools, biochemical assays and lipidomics.
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Arenberg Prize voor Benjamin van Soldt
Oud-biologiestudent Benjamin van Soldt heeft de Arenberg-Coimbra Group Prize for Erasmus Students 2015 gewonnen. Die gaat naar de Erasmusstudent van een van de Coimbra-universiteiten die wetenschappelijk gezien het meest uit de Erasmus-uitwisseling heeft gehaald.
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Goldsmith Book Prize voor Daniela Stockmann
De Leidse politicoloog Daniela Stockmann heeft de Goldsmith Book Prize 2015 gekregen voor het beste academische boek op het gebied van media, politiek en overheidsbeleid. De jury roemde het als 'een van de belangrijkste werken die ooit met de Goldsmith Award zijn bekroond.'
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Milan Allan wint Bryan R. Coles Prize
Milan Allan heeft de Bryan R. Coles Prize gewonnen op de International Conference on Strongly Correlated Electron Systems (SCES) in Praag.
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Michel Orrit wint Edison Volta Prize
De European Physical Society heeft de prestigieuze Edison Volta Prize toegekend aan Leids natuurkundige Michel Orrit. De prijs wordt elke twee jaar uitgereikt aan een individu of groep van maximaal 3 wetenschappers ter erkenning van een buitengewone prestatie in natuurkundig onderzoek.
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Vestert Borger ontvangt UACES Best Book Prize
Op 6 september 2021 heeft dr. Vestert Borger, universitair docent Europees recht, de Best Book Prize ontvangen van de University Association for Contemporary European Studies (UACES). Borger ontving de prijs voor zijn boek The Currency of Solidarity: Constitutional Transformation during the Euro Cri…
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Bert Fraussen wint Harold D. Lasswell Prize
Met de publicatie “Think tanks and strategic policy-making: the contribution of think tanks to policy advisory systems” heeft Bert Fraussen, als universitair docent verbonden aan het Instituut Bestuurskunde, de Harold D. Lasswell Prize gewonnen.
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Galileo Masters Regional Prize
De drie studenten namen aan de competitie deel met een businessplan dat ze ontwikkelden tijdens een cursus ondernemen. Ze ontwierpen een succesvol en goedkoop systeem om slachtoffers van sneeuwlawines onder de sneeuw te lokaliseren. De huidige navigatietechniek voor satellieten biedt de benodigde accuratesse…
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CML researcher David Font Vivanco won the Graedel Prize 2014
PhD researcher David Font Vivanco, together with Ester van der Voet, Reinout Heijungs and Renée Kemp (Maastricht University) won the Graedel Prize 2014 for best paper published by a junior author in the Journal of Industrial Ecology.
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Jong talent: quantumwetenschapper ontvangt Young Scientist Prize
Pas 35 jaar en nu al leider van een onderzoeksgroep, op weg naar vaste aanstelling. En: talloze papers, subsidies en beurzen op zijn naam. Leidse natuurkundige Jordi Tura i Brugués ontvangt vandaag de Young Scientist Prize voor zijn bijzondere bijdragen aan quantum-onderzoek.
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Unilever Research Prize voor masterstudent Lukas Kiefer
Leidse Biologiestudent Lukas Kiefer heeft de Unilever Research Prize 2018 gewonnen voor zijn onderzoek naar de efficiënte productie van een nieuw antibioticum. Kiefer: 'Ik wil biologische medicijnen beschikbaar maken voor mensen in nood.'
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Murad BozikWiskunde en Natuurwetenschappen
m.h.bozik@liacs.leidenuniv.nl | +31 71 527 2727
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David Font Vivanco heeft Environmental Sciences Research Prize gewonnen
De Environmental Sciences Research Prize 2012 is uitgereikt aan CML onderzoeker David Font Vivanco door de Environmental Scientists Association van Catalonië.
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Hendrik Casimir Prize 2017 voor Nashwan Sabti en Nikolas Kavadias
Op de LION/Sterrewacht nieuwjaarsborrel hebben natuurkundestudenten Nashwan Sabti (Leiden) en Nikolas Kavadias (Delft) de 2017 Hendrik Casimir Prize in ontvangst genomen. The Casimir Research School deelt jaarlijks de Hendrik Casimir Prize uit aan de beste masterstudenten in (technische) natuurkunde…
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Hendrik Casimir Prize 2016 voor Andrea Peña en Jorrit Hortensius
Op de LION/Sterrewacht nieuwjaarsborrel heeft prof. Tjerk Oosterkamp de 2016 Hendrik Casimir Prize uitgereikt aan natuurkundestudenten Andrea Peña (Leiden) en Jorrit Hortensius (Delft). The Casimir Research School deelt jaarlijks de Hendrik Casimir Prize uit aan de beste masterstudenten in (technische)…
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Marc Koper wint Brian Conway Prize 2016 voor elektrochemie
Marc Koper, hoogleraar Katalyse en oppervlaktechemie, heeft de Brian Conway Prize for Physical Electrochemistry van de International Society of Electrochemistry (ISE) gewonnen. De ISE jury koos hem als winnaar vanwege zijn uitzonderlijke bijdrage aan de fysische elektrochemie.