The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

Op 10 oktober 2019 verdedigde Janneke Vink haar proefschrift 'The Open Society and Its Animals'. Het promotieonderzoek is begeleid door promotor prof.dr. P.B. Cliteur.

Promotie

It’s Not Easy Being Green – maar we zijn hier om te helpen! Wil je duurzamer leven maar heb je geen idee waar je moet beginnen? Ben je geïnteresseerd in het groener maken van de wereld en wil je hot topics doorgronden? Of sta je sceptisch tegenover klimaatverandering en wil je meer weten over de…

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

Solar energy harnessed by plants and algae has great potential to be converted into biofuels for future generations.

Promotores: Prof.dr. S.J. Edixhoven, Prof.dr. E. Ullmo (University Paris-Sud)

Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)

This thesis probes under what conditions quantum computing presents an advantage over classical computing.

This article 'Shaping the European External Action Service and its post-Lisbon crisis management structures: an assessment of the EU High Representatives’ political leadership' assesses the role, influence and core aspects of the EU High Representatives’ (HR/VPs) “political leadership” in the context…

n this thesis we study curves. In the first half, we study moduli spaces of curves and Gromov-Witten invariants, certain kinds of curves counts. We employ logarithmic geometry for this.

Schuurman onderzoekt hoe Rusland zijn geheime operaties tegen Europese landen laat escaleren.

Op 1 november promoveert Andrew Wigman. Het Leiden University Centre for Linguistics feliciteert Andrew!

Op 29 april 2020 verdedigde Beth Van Schaack haar proefschrift 'Imagining Justice for Syria: Water Always Finds Its Way'. Het promotieonderzoek is begeleid door promotor prof.dr. C. Stahn.

Op 23 juni 2020 verdedigde Santy Kouwagam haar proefschrift 'How lawyers win land conflicts for corporations: Legal Strategy and its influence on the Rule of Law in Indonesia'. Het promotieonderzoek is begeleid door promotoren prof.dr. A.W. Bedner en prof.dr. C.E. von Benda-Beckmann.

We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

Promoter: Ed F. Deprettere, Co-promoter: Todor P. Stefanov

Op 11 juni 2020 verdedigde Sabine Witting haar proefschrift 'Child Sexual Abuse in the Digital Era: Rethinking Legal Frameworks and Transnational Law Enforcement Collaboration'. Het promotieonderzoek is begeleid door promotoren prof.mr. J.J. Sloth-Nielsen en prof.dr.mr. S. van der Hof.

Continuous optimization is never easy: the exact solution is always a luxury demand and the theory of it is not always analytical and elegant.

Promotor: S.J. Edixhoven, Co-promotor: R.S. de Jong

Hoe beïnvloedt de vernietiging van universiteiten in Gaza, ook wel 'scholasticide' genoemd, het wetenschappelijk leven en wat zijn de theoretische en juridische onderbouwingen van de term?

Op 10 maart 2021 verdedigde Pieter Huizing zijn proefschrift 'Parallel Enforcement of International Cartels and Its Impact on the Proportionality of Overall Punishment'. Het promotieonderzoek is begeleid door promotor prof.mr. T.R. Ottervanger.

In this article, Eamon Aloyo argues that university supervisors should not use student evaluations of teachers as a measure of teaching effectiveness.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Hoewel veel beroepsbeoefenaren in de gezondheidszorg aangeven vaak gebruik te maken van placebo-effecten en de mechanismen ervan, is er weinig formele training over hoe om te gaan met placebo- en nocebo-effecten in de klinische praktijk. Dit project wil deze kloof tussen wetenschappelijke kennis over…

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

Promotor: A. Kros

Lezing, Lezingenreeks vergelijkende Indo-Europese taalwetenschap (VIET)

Promotie

Promotor: Prof.dr. P. Stevenhagen, Prof.dr. K. Belabas (Univ. de Bordeaux)

Galaxies form and live inside dark matter haloes. As a consequence, they are exposed to the tidal fields generated by the surrounding matter distribution: this imprints a preferential direction to the galaxy shapes, which leads to a coherent alignment on physically close galaxies, called intrinsic a…

This thesis is largely an experimental study on the formation of solid-state simple and complex organic molecules in the H2O-rich and CO-rich ice phases of dense interstellar clouds and dark cores.

Promotores: H.W. Lenstra, K. Belabas (University of Bordeaux)

How should jurisdictions, both on the national and on the supra-national level, handle the interaction between public and private law where it regards the regulation of financial markets?

World Teachers Festival 2024 - Celebrating and exploring language, culture, diversity and criticality in teaching and learning

This proposed research uses ego-documents from visual artists that were not intended for publication to reassess the scholarly debate on the demise of the Russian Avant-garde aesthetic in the twenties and early thirties of the 20th century.

To an algebraic curve C over the complex numbers one can associate a non-negative integer g, the genus, as a measure of its complexity.

Op 11 november 2021 verdedigde Mariana Gkliati het proefschrift 'Systemic Accountability of the European Border and Coast Guard'. Het promotieonderzoek is begeleid door promotoren prof.dr. P. Rodrigues en prof.dr. L. Besselink (UvA).

We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…

When a star is born in our Galaxy, it is quite likely that it has formed within a massive cluster, which hosts numerous high-mass stars bathing their lower mass neighbours in UV radiation.

Promotores: H.W. Lenstra, A. Lucchini

Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.

Promotores: Prof.dr. J. Schaye & Prof.dr. C. Steidel (California Institute of Technology)

Promotores: G.A. Persoon, H.H. de Iongh

This dissertation explores how we can make anomaly detection—identifying unusual or faulty behavior in complex systems—more trustworthy and effective, with a focus on smart manufacturing.

Electrons in a crystal lattice have properties that may differ from those of a free electron in vacuum.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Regeneration is the ability of an organism to restore damaged or lost tissue with a functional replacement, and without scarring. Many lizards can regenerate their tails.