2,213 zoekresultaten voor “the hague” in de Publieke website
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Explicit Computation of the Height of a Gross-Schoen Cycle
Arithmetic geometry concerns the number-theoretic properties of geometric objects defined by polynomials. Mathematicians are interested in the rational solutions to these geometric objects.
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More JAZ in the orchestration of jasmonate-mediated plant defense
Prof.dr. J. Memelink
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improved drug action : target binding kinetics and functional efficacy at the mGlu2 receptor
During the course of drug discovery translational steps are made.
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bioaccumulation and trophic transfer of engineered nanoparticles in the aquatic environment
The findings in this thesis improve the understanding of 1) the relationship between exposure characteristics and toxicity of ENPs, 2) the joint toxic action of ENP mixtures and the comparison to metal salt mixtures, 3) how NOM affects the individual and joint toxicity of ENPs, 4) the extent of trophic…
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mechanisms underlying inflammation and infection control: insights from the zebrafish model
This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.
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Investigations on the role of impaired lysosomes of macrophages in disease
The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
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The Sand Motor - Building with Nature to optimise coastal protection and other ecosystem services
How can mega sand nourishments, such as the Sand Motor, be designed and managed for optimal ecosystem services provision ?
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Young suns and infant planets: Probing the origins of solar systems
Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).
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Discovering the preference hypervolume: an interactive model for real world computational co-creativity
In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.
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The spin evolution of accreting and radio pulsars in binary systems
Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.
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Hydrodynamics and the quantum butterfly effect in Black Holes and large N quantum field theories
Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?
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Environmental assessment and guidance for the future offshore wind energy development
This thesis aims to address offshore wind energy (OWE)-related environmental impacts.
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Freedom of additional signals on genes: on the combination of DNA mechanics, genetics and translation speed
DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.
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Insights into microtubule catastrophes: the effect of end-binding proteins and force
For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.
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Selectivity and competition between the anodic evolution of oxygen and chlorine
Sustainable energy from wind and solar is most readily available near the sea.
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The innate immune response against mycobacterial infection: analysis by a combination of light and electron microscopy
Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf
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Unraveling the auxin mechanism in 2,4-D induced somatic embryogenesis in Arabidopsis thaliana
Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa
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The tension between nature conservation and economic valuation of ecosystem services
Promotores: G.R. de Snoo, W.T. de Groot, Co-promotor: C.J.M. Musters
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Impact of nitrogen fertilization on the soil microbiome and greenhouse gas emission
The use of N fertilizers has increased worldwide in the past century. While this increased input of N has increased food productivity, it has also contributed to decreases in biodiversity, soil quality and environmental health, including increases in greenhouse gas emissions.
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Deepening the uncertainty dimension of environmental Life Cycle Assessment: addressing choice, future and interpretation uncertainties.
LCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability.
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T-CYCLE EPR: Development at 275 GHz for the study of reaction kinetics & intermediates
A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.
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Causal Discovery from High-Dimensional Data in the Large-Sample Limit
Developing robust algorithms and theory for establishing cause-effect relationships from observational data that scale up to large data sets
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Paul Scholten. Book chapter in Great Christian Jurists in the Low Countries
Timo Slootweg, associate professor at he department Philosophy of Law, published a chapter about Paul Scholten in
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Ingrid Leijten publiceert boek Core Socio-Economic Rights and the European Court of Human Rights
Bij Cambridge University Press (CUP) verscheen onlangs van Ingrid Leijten het boek Core Socio-Economic Rights and the European Court of Human Rights. Het boek maakt onderdeel uit van de serie Cambridge Studies in European Law and Policy en heeft als onderwerp de bescherming van sociaaleconomische rechten…
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The integration of meta-analysis and classification & regression trees: meta-CART
In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).
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The road to insurmountability: Novel avenues to better target CC Chemokine receptors
This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.
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Ladies-only! Empowerment and Comfort in Gender-segregated Kickboxing in the Netherlands
The experiences of ethnic ‘Other’ females have – until recently – been widely overlooked in the study of sport. There continues to be a need to produce critical scholarship about ethnic 'Other' girls and women in sport and physical culture, in order to represent their complex, multifarious and dynamic…
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Suppressing a Sea of Starlight: Enabling technology for the direct imaging of exoplanets
Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik
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The evolution and plasticity of life histories upon variation in nutrition: on aging focused integrative approach
Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)
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Bridging the gap between physics and chemistry in early stages of star formation
A dense region of a gaseous and dusty cloud collapses to form a protostar surrounded by a disk and an envelope. This thesis uses both observations and models to study physical and chemical conditions of these protostellar systems which are likely where planets start to form.
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The quantification of growth hormone secretion : application of model-informed drug development in acromegaly
Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.
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Exploring the chemical space of post-translationally modified peptides in Streptomyces with machine learning
The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.
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The structure of a working catalyst: from flat surfaces to nanoparticles
Promotor: Prof.dr. J.W.M. Frenken
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Imaging polarimetry for the characterisation of exoplanets and protoplanetary discs. Scientific and technical challenges
Promotor: Prof.dr. C.U. Keller
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Bronzen predicaat Elsevier Beste Studies 2022 voor LUC
Het Leiden University College The Hague (LUC) heeft een bronzen medaille ontvangen van de ranglijst Elsevier Beste Studies 2022. Dat betekent dat de studenten bovengemiddeld tevreden zijn over de kwaliteit van de opleiding en de opleiding het beter doet dan gemiddeld. Elsevier vergelijkt elk jaar een…
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System-level design for efficient execution of CNNs at the edge
A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.
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Management implications for invertebrate assemblages in the Midwest American agricultural landscape
Promotor: G.R. de Snoo Co-promotor: C.J.M. Musters
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Models of curves: The Birch and Swinnerton-Dyer conjecture & ordinary reduction
Chapter 1,contains the numerical verification of the Birch and Swinnerton-Dyer conjecture for hundreds of Jacobians of hyperelliptic curves of genus 2, 3, 4 and 5.
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Multi-omics studies of the control of growth and antibiotic production of Streptomyces
Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).
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Photoinduced processes in dye-sensitized photoanodes under the spotlight: a multiscale in silico investigation
With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…
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The evolution of chemical diversity in plants : pyrrolizidine alkaloids and cytochrome P450s in Jacobaea
Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.
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Development of human skin equivalents to unravel the impaired skin barrier in atopic dermatitis skin
Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri
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Understanding the uptake and internal distribution of metallic nanoparticles in Danio rerio larvae
The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.
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Stress-induced modulation of the innate immune system in cardiovascular disease
Promotor: Prof.dr. J. Kuiper
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Advances in GPCR Modeling Evaluated by the GPCR Dock 2013 Assessment: Meeting New Challenges
Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)
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The architects of crenarchaeal chromatin: A biophysical characterization of chromatin proteins from Sulfolobus solfataricus
Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame
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The role of zebrafish larvae for studying anxiety-like behaviour
The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.
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The music of language: exploring grammar, prosody and rhythm perception in zebra finches and budgerigars
Promotor: C.J. ten Cate
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Corporate venture management in SMEs: evidence from the German IT consulting industry
Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)