1,911 zoekresultaten voor “3d modelling” in de Publieke website
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Stochastic resetting and hierarchical synchronisation
Stochastic resetting is simple enough to be approached analytically, yet modifies stochastic processes in a non-trivial way.
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Proteins in harmony: Tuning selectivity in early drug discovery
This thesis describes the importance of being able to control the selectivity of potential drug candidates.
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Actors at work
Promotor: F.S. de Boer Co-promotor: P. T. de Gouw
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NMR studies of protein-small molecule and protein-peptide interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
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Anyonic, cosmic, and chaotic: three faces of Majorana fermions
In my thesis I study Majorana fermions from three different perspectives. The first one corresponds to non-interacting Majorana fermions that, however, pose non-trivial topological properties. The second one corresponds to strongly interacting Majoranas and the third to relic neutrinos. No one knows…
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Calculated Moves: Generating Air Combat Behaviour
By training with virtual opponents known as computer generated forces (CGFs), trainee fighter pilots can build the experience necessary for air combat operations, at a fraction of the cost of training with real aircraft.
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Improving vegetation representation in Multi-sensor Earth Observation Products through phenology and trait-based priors
What are the behaviours of plant traits throughout various points in the growing season in a radiative transfer model framework and how well can this knowledge be integrated through data assimilation to provide priors for robust local and global vegetation products and analysis?
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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Ga mee op zoek naar het geheim van ‘Marokkaanse model’ : Studiereis islam, gender, en burgerschap
Marokko is een van de weinige landen in Noord-Afrika die aan de Arabische lente een vreedzame vorm heeft weten te geven door het pad van brede, gestage politieke hervormingen op te gaan. De Marokkaanse overheid verklaart de relatieve maatschappelijke rust daarnaast ook door haar islampolitiek, gericht…
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Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
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Blowup in the complex Ginzburg-Landau equation
Promotor: Prof.dr. A. Doelman, Co-promotor: V. Rottschäfer
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G-zips and Ekedahl-Oort strata for Hodge type Shimura varieties
Promotores: S.J. Edixhoven, F. Andreatta
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Multi-Biomarker Pharmacokinetic-Pharmacodynamic Relationships of Central Nervous Systems Active Dopaminergic Drugs
Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: M. Danhof, Co-promotor: E.C.M. de Lange
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Mirko Forastiere
Wiskunde en Natuurwetenschappen
m.forastiere@cml.leidenuniv.nl | +31 71 527 2727
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Sebastiaan Deetman
Wiskunde en Natuurwetenschappen
s.p.deetman@cml.leidenuniv.nl | +31 71 527 5616
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Ruben Huele
Wiskunde en Natuurwetenschappen
huele@cml.leidenuniv.nl | +31 71 527 FLEX
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3D learning in anatomical and surgical education in relation to visual- spatial abilities
Promotie
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On transport properties of Majorana fermions in superconductors: free & interacting
Majorana fermions in superconductors are the subgap quasiparticle excitations that are their own antiparticles.
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Liposome-based synthetic long peptide vaccines for cancer immunotherapy
Promotores: Wim Jiskoot; Ferry Ossendorp
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Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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Uniform infinite and Gibbs causal triangulations
Promotor: Richard D. Gill
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Lipid mediated colloidal interactions
The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.
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Structural Health Monitoring Meets Data Mining
Promotor: Prof.dr. J.N. Kok, Co-promotor: A.J. Knobbe
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When data compression and statistics disagree: two frequentist challenges for the minimum description length principle
Promotor: P.D. Grünwald
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Ruthenium-peptide conjugates for targeted phototherapy
As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Monitoring Alzheimer's disease in transgenic mice with ultra high field magnetic resonance imaging
Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia
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Stofwisselingsonderzoek opschalen met bedrijven
Voorspellen of iemand ziek wordt en bij welke behandeling een patiënt het meest baat heeft. Dat is het doel van de technieken die hoogleraar Analytische biowetenschappen Thomas Hankemeier met zijn onderzoeksgroep aan de Universiteit Leiden ontwikkelt. Om die technologie op te schalen en verder te ontwikkelen,…
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RNA splicing in breast cancer progression
In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.
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Molecules during stellar formation and death
Promotor: Prof.dr. E. F. van Dishoeck
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Design and application of dextran based cross-linked networks
This thesis describes the design, characterization and application of dextran based crosslinked network.
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Quantitative Super-Resolution Microscopy
Promotor: T. Schmidt
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Role of integrin adhesions in cellular mechanotransduction
Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen
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Fluorescence Correlation Spectroscopy on Electron Transfer Reaction: Probing Inter- and Intramolecular Redox Processes
Promotores: G.W. Canters, T.J. Aartsma
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High throughput microscopy of mechanism-based reporters in druginduced liver injury
Promotor: B. van de Water
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Novel detectors and algorithms for electron nano-crystallography
Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel
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Spectral imaging and tomographic reconstruction methods for industrial applications
Radiography is an important technique to inspect objects, with applications in airports and hospitals. X-ray imaging is also essential in industry, for instance in food safety checks for the presence of foreign objects.
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Real-time tomographic reconstruction
With tomography it is possible to reconstruct the interior of an object without destroying.
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Franco Donati
Wiskunde en Natuurwetenschappen
f.donati@cml.leidenuniv.nl | +31 71 527 2727
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Invariant manifolds and applications for functional differential equations of mixed type
Promotor: S.M. Verduyn Lunel
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Project SkinPrint van Leidse masterstudenten wint de Digital Award van de Philips Innovation Award
Vier Leidse studenten die de masterspecialisatie Science Based Business volgen, bedachten een concept om met een 3D Bioprinter menselijke huid te produceren. Slachtoffers van brandwonden zouden dankzij Skinprint minder operaties nodig hebben en er minder littekens aan over houden.
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Concepts and applications for evidence-based dosing in morbidly obese patients before and after weight loss surgery
Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst
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Dual Complexes of Semistable Varieties
This thesis is comprised of three chapters covering the theme of studying semistable varieties by looking at their dual combinatorial objects.
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Regulation of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
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Archeologen reconstrueren bouwlust oude Grieken
In Mykeens Griekenland verschenen vanaf 1600 v. Chr. zeer veel monumentale bouwwerken zoals grote graftombes. Waarom stopte die bouwlust 400 jaar later abrupt? Archeoloog Ann Brysbaert onderzoekt de mogelijke oorzaken dankzij haar ERC Consolidator Grant.
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Amie Corbin
Wiskunde en Natuurwetenschappen
a.e.corbin@cml.leidenuniv.nl | +31 71 527 2727
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Dirk-Jan Kok
Wiskunde en Natuurwetenschappen
d.d.kok@cml.leidenuniv.nl | +31 71 527 2727
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Weilin Huang
Wiskunde en Natuurwetenschappen
w.huang@cml.leidenuniv.nl | +31 71 527 2727