495 zoekresultaten voor “cancer research” in de Publieke website
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BRCA1-associated breast cancer: finding new weapons for an old villain
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Exploring Grainyhead-like 2 target genes in breast cancer
The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.
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RNA splicing in breast cancer progression
In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.
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Novel regulators of prostate cancer stem cells and tumor aggressiveness
Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm
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Discovery of BUB1 kinase inhibitors for the treatment of cancer
The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.
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Identification of novel targets in prostate cancer progression
Promotor: B. van de Water, Co-promotor: E.H.J. Danen
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Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
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PI3K signaling and adherens junctions in invasive lobular breast cancer
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.
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Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
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Precision modeling of breast cancer in the CRISPR era
The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.
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genes driving tumorigenesis and therapy resistance in human breast cancer
To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.
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Image-based phenotypic screening for breast cancer metastasis drug target discovery
The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.
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Uncovering vulnerabilities in triple-negative breast cancer
Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.
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Liposome-based synthetic long peptide vaccines for cancer immunotherapy
Promotores: Wim Jiskoot; Ferry Ossendorp
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
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The diverse roles of integrin α3β1 in cancer: Lessons learned from skin and breast carcinogenesis
In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.
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Cell-autonomous and host-dependent CXCR4 signaling in cancer metastasis: insights from a zebrafish xenograft model
Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska
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Early Detection of Pancreatic Cancer in High-Risk Individuals
Promotie
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Upconverting nanovesicles for the activation of ruthenium anti-cancer prodrugs with red light
Promotor: E. Bouwman, Co-promotor: S. Bonnet
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actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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xenograft model: identification of novel mechanisms driving prostate cancer metastasis
Prostate cancer (PCa) is one of the most prevalent cancer in males.
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PLGA-based particulate vaccine delivery systems for immunotherapy of cancer
Promotores: W. Jiskoot, F. Ossendorp
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The good? The bad? The mutant! Characterization of cancer-related somatic mutations and identification of a selectivity hotspot in adenosine
G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.
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Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
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Phenotypic screening with 3D cell-based assays
Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.
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Supporting women with breast cancer in making an informed decision about immediate breast reconstruction
Promotie
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Colorectal cancer screening for average- and high-risk individuals Beyond one-size-fits-all
Promotie
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Research
The mission of our group is understanding how science communication works to improve the interaction between science and society. We believe better science communication can improve our society and engage many different groups with science, also improving science.
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the response to immunotherapy in patients with non- small cell lung cancer
Promotie
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Screening the CITY: Optimizing population-based cancer screening in the Netherlands from a primary care perspective
Promotie
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History (research) (MA)
De onderzoeksmaster History (research) van de Universiteit Leiden biedt een keuze uit vijf specialisaties waarin je je richt op historische processen, geschiedkundig onderzoek, historiografie en methodologie.
- Psychology (research) (MSc)
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Classics (research) (MA)
De onderzoeksmaster Classics (research) van de Universiteit Leiden maakt je vertrouwd met multidisciplinair onderzoek naar de Griekse en Romeinse wereld.
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Assyriology (research) (MA)
De onderzoeksmaster Assyriology (research) van de Universiteit Leiden is een multidisciplinaire opleiding in de talen, literatuur en cultuur van het Oude Nabije-Oosten.
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Egyptology (research) (MA)
De onderzoeksmaster Egyptology (research) van de Universiteit Leiden is een multidisciplinaire opleiding in de talen, literatuur en cultuur van het Oude Egypte.
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Ancient History (research) (MA)
In de specialisatie Ancient History (research) van de Universiteit Leiden bestudeer je de geschiedenis van de Griekse en Romeinse periode, in het bijzonder de mentaliteit en de sociale en economische geschiedenis in de periode van 400 voor Chr. tot 400 na Chr.
- Developmental Psychology (research) (MSc)
- Cognitive Neuroscience (research) (MSc)
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Linguistics (research) (MA)
De onderzoeksmaster Linguistics (research) van de Universiteit Leiden combineert de expertise van vooraanstaande wetenschappers met een flexibel programma.
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African Studies (research) (MA)
De interdisciplinaire onderzoeksmaster African Studies (research) van de Universiteit Leiden is uniek in Europa vanwege de veelvoud aan perspectieven.
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G. Rozenberg Research Award
Informatie over de de G. Rozenberg Research Award van het Leiden Institute of Advanced Computer Science (LIACS) is beschikbaar in het Engels.
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Asian Studies (research) (MA)
De tweejarige onderzoeksmaster Asian Studies (research) geeft toegang tot het wereldvermaarde onderzoeksprogramma van de Universiteit Leiden op het gebied van de Aziatische landen, van politiek en literatuur tot taal.
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Archeologie (research) (MA/MSc)
De onderzoeksmaster Archaeology is de meest diverse in haar soort in Nederland. Profiteer van onze kennis, ervaring en internationale reputatie in de archeologie en leg de juiste basis voor jouw toekomst in de wetenschap.
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Research Support Team
Het Research Support Team (RST) van het Instituut Security and Global Affairs biedt uitgebreide ondersteuning en tijdig advies aan onderzoekers als het gaat om het vinden van relevante beschikbare beurzen of fondsen.
- Foundations of Research – 2: Conceptualization, Research Questions, Composition (3 ECTS)
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Astronomy Research (MSc)
In deze opleiding ligt de focus op data-analyse en simulatie, waarbij je sterrenkunde combineert met natuurkunde, wiskunde en informatica.
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Cancer Drug Discovery Initiative maakt nieuwe therapieën tegen kanker mogelijk
Het Antoni van Leeuwenhoek/Nederlands Kanker Instituut, het Leids Instituut voor de Chemie en het Pivot Park Screening Centre gaan kennis en infrastructuur delen in het Cancer Drug Discovery Initiative. Vrijdag 11 oktober tekenden ze een letter of intent.
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Research Seminar Series
Elke week organiseert ISGA de Research Seminar Series waarin onderzoek van zowel medewerkers van ISGA als van externen aan bod komt.