703 zoekresultaten voor “complex adhesives” in de Publieke website
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Multi Modal Representation Learning and Cross-Modal Semantic Matching
Humans perceive the real world through their sensory organs: vision, taste, hearing, smell, and touch. In terms of information, we consider these different modesalso referred to as different channels of information or modals.
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Exploring chemical space in covalent and competitive glycosidase inhibitor design
Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency
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Forces and symmetries in cells and tissues
The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.
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Protoplanetary disk anatomy: examining the structure and chemistry of planetary birthplaces with simple molecules
This thesis examines the link between simple molecules and the underlying structure and chemistry within protoplanetary disks - the birthplaces of planets.
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Strategies for braiding and ground state preparation in digital quantum hardware
With the help of quantum mechanics, digital quantum hardware may be able to tackle some of the problems that are too difficult for ordinary computers. But despite these expectations and the ongoing effort of the research community, reliable quantum computers are not yet realized in a lab setting.
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Nuclear Quantum Effects in Solid Water
Ice, the solid state of water, plays an important role on our planet as well as the entire universe.Despite the fact that an individual water molecule has a very simple structure, its chemical bonding in the solid phase can be surprisingly complex.
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Temminck's Order. Debates on Zoological Classification: 1800-1850
“Temminck’s Order” is the scientific biography of Coenraad Jacob Temminck (1778–1850), a Dutch naturalist and the first director of ’s Rijks Museum van Natuurlijke Historie in Leiden.
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Bridging the gap between physics and chemistry in early stages of star formation
A dense region of a gaseous and dusty cloud collapses to form a protostar surrounded by a disk and an envelope. This thesis uses both observations and models to study physical and chemical conditions of these protostellar systems which are likely where planets start to form.
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Bioorthogonal chemistry to unveil antigen processing events
The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.
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Photocleavable activity-based acid glucosylceramidase probes
Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…
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De strijd van gelijkheid en vrijheid
Moeten alle mensen gelijk worden behandeld? En alle opvattingen? Een bevestigend antwoord op deze vragen ligt voor de hand.
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Unravelling cell fate decisions through single cell methods and mathematical models
Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.
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Good governance and the rule of law
Op welke manier ontwikkelt de ‘rule of law’ zich in Westerse samenlevingen in het licht van de opkomst en verspreiding van diverse digitale technologieën en hoe kan de rule of law invloed hebben op het gebruik en de verspreiding van deze technologieën.
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Design and synthesis of metal-based chemotherapeutic agents for targeted DNA interactions or DNA repair pathway modulation
The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…
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Multi-dimensional feature and data mining
In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.
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Supramolecular peptide amphiphile nanoparticles as a novel allergy vaccine platform
Bet v1, the major allergen in birch pollen, is one of the main causes of allergies such as asthma and rhino-conjunctivitis. It is the main cause of birch pollen allergy in humans.
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Systems pharmacology of the amyloid cascade
According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).
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De intergenerationele overdracht van extreme gedachtensystemen
Met de recente opkomst en val van IS uiten academici en beleidsmakers over de hele wereld hun bezorgdheid over het lot van kinderen van voormalige buitenlandse strijders. Zullen zij in de voetsporen van hun ouders treden? In dit artikel belichten Layla van Wieringen, Daan Weggemans en Marieke Liem de…
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Extracurriculair
Wij dagen studenten uit hun talenten verder te ontwikkelen. Binnen de universiteit en opleiding zijn hier verschillende mogelijkheden voor, waaronder uitwisseling via het EMPA-netwerk, Leiden Leadership Programme en Master Honours Classes & Challenges.
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LUMC Hoofdgebouw
Albinusdreef 2, Leiden
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Self-assembly of flexible and rigid structures: from colloidal molecules to lattices
Self-assembly offers a promising route to create complex structures and materials using simple building blocks. Through, colloidal self-assembly, we can understand the governing principles of the self-assembly process and unlock its potential in diverse applications in materials science, photonics and…
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Design and development of conformational inhibitors and activity-based probes for retaining glycosidases
Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.
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Towards automated identification of metabolites using mass spectral trees
Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers
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Modelling the dynamics of the innovation process: a data-driven agent-based approach
Promotor: Prof.dr. B.R. Katzy
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Uyt saecke des doots
Al eeuwenlang wordt in Nederland bij overlijden belasting geheven over de verkregen erfenissen. De heffing van deze erfbelasting staat niet alleen ter discussie vanwege de vermeende dubbele heffing en het beklemmende aanknopingspunt, maar ook vanwege de mogelijkheden om via slimme juridische constructies…
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Algorithms for the description of molecular sequences
Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros
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Protein arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…
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Over het project
De nieuwbouw voor de Faculteit der Wiskunde en Natuurwetenschappen is een belangrijke mijlpaal voor de Universiteit Leiden en de faculteit in het bijzonder. In drie fasen wordt een nieuw gebouw gerealiseerd. De eerste fase van het nieuwe gebouw is in 2016 in gebruik genomen en beslaat 45.000m2. Het…
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Ladies-only! Empowerment and Comfort in Gender-segregated Kickboxing in the Netherlands
The experiences of ethnic ‘Other’ females have – until recently – been widely overlooked in the study of sport. There continues to be a need to produce critical scholarship about ethnic 'Other' girls and women in sport and physical culture, in order to represent their complex, multifarious and dynamic…
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VERBODEN TOEGANG! – Het recht op onderwijs voor meisjes, met een focus op Pakistan
Welke uitdagingen bestaan er voor meisjes in het uitoefenen van hun recht op onderwijs en in het bijzonder het krijgen van toegang tot onderwijs?
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Extracurriculair
Haal zoveel mogelijk uit je studie aan de Univeriteit Leiden door deel te nemen aan onze extracurriculaire activiteiten.
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Extracurriculair
Haal zoveel mogelijk uit je studie aan de Univeriteit Leiden door deel te nemen aan onze extracurriculaire activiteiten.
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Extracurriculair
Haal zoveel mogelijk uit je studie aan de Univeriteit Leiden door deel te nemen aan onze extracurriculaire activiteiten.
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Extracurriculair
Farmacie is een uitdagende studie die als intensief wordt ervaren. Heb jij naast je studie echter nog tijd om je verder te ontwikkelen? Dan is het Leadership Programme van de Universiteit Leiden wellicht iets voor jou.
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Extracurriculair
Haal zoveel mogelijk uit je studie aan de Univeriteit Leiden door deel te nemen aan onze extracurriculaire activiteiten.
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Chemical reactivity of O2, CO and CO2 on Cu surfaces
Despite the history of studies on methanol formation from CO2, the dominant elementary reaction steps that constitute the chemical mechanism for this catalyzed process are not determined.
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Triblock polypept(o)ides for siRNA delivery: unique polymeric designs for versatile carrier systems
Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…
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Cyber Security (MSc)
Ben jij een professional die een master wil doen? En heb jij een relevante achtergrond, zoals een HBO master of WO opleiding en enige jaren werkervaring? Dan kun je ervoor kiezen om je kennis in Cyber Security te verbreden en te verdiepen.
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The developing infant gut microbiota: mathematical predictions of the effects of oligosaccharides
A complex community of microbes develops in the infant gut shortly after birth. We call this community the infant gut microbiota. The microbiota influences the health of the infant, which makes the composition and function of the infant gut microbiota an important topic to study.
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Genomics applications of nanopore long-read sequencing for small to large sized genomes
In this thesis I highlight the applications of Oxford Nanopore Technologies (ONT) sequencing. This technique is a relatively new approach in the sequencing field, where nanopores are embedded in a membrane, DNA molecules are pulled through nanopores and an electrical current serving as the sequencing…
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Heterogenized molecular (pre)catalysts for water oxidation and oxygen reduction
Before the large scale use of renewable energy sources can be implemented in our society, the storage of electrical energy needs to be tackled. Storage the energy as hydrogen via the reduction of protons is a good option.
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Towards artificial photosynthesis on the lipid bilayer of liposomes
Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.
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Preclinical validation of putative targets in cardiovascular and metabolic disease
Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.
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Bouw van de Bibliotheek
De Universitaire Bibliotheken Leiden bouwt een nieuwe Middle Eastern Library. Deze nieuwe bibliotheek zal zich bevinden in het hart van Cluster Zuid op de nieuwe Humanities Campus. Ze heeft tot doel de academische gemeenschap te ondersteunen en een prettige studie- en werkomgeving te bieden met moderne…
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Photosynthetic light reactions at the gold interface
Promotor: T.J. Aartsma, Co-promotor: R.N. Frese
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Van Torentje tot Trêveszaal. De geschiedenis van de noordzijde van het Binnenhof
Het Binnenhof is het centrum van de politiek in Nederland. De eeuwenoude politieke functie van dit gebouwencomplex in Den Haag en de combinatie van bestuur, regeringsleiding en volksvertegenwoordiging op één plaats maken het Binnenhof een uniek brandpunt van de geschiedenis van Nederland.
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Going global to local: achieving agri-food sustainability from a spatially explicit input-output analysis perspective
The global agri-food system plays a critical role in food security and environmental issues.
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Structural characterization of bacterial proteins involved in antibiotic resistance and peptidoglycan biosynthesis
This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.
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Dear Future Me
Behavioral and neural mechanisms underlying self-concept development in relation to educational decision-making in adolescence