220 zoekresultaten voor “equal treatment” in de Publieke website
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Fate, accumulation and impact of metallic nanomaterials in the terrestrial environment
The rapidly increasing commercial application of metallic nanoparticles within products will inevitably enhance the amount of NPs being released into soil.
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New Approaches to Imaging and Treatment of Ocular Melanoma
Promotie
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Prosthetic Joint Infection, new diagnostic and treatment strategies
Promotie
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Systemic Treatment in Malignant Mesothelioma: Treat it or Leave it
Promotie
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Discrepancies in diagnoses and treatment of type B ankle fractures
Promotie
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Towards personalized treatment for high risk endometrial cancer
Promotie
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Substrate Identification and Treatment of Right Ventricular Tachycardia
Promotie
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Optimizing antiseizure medication treatment in glioma patients with epilepsy
Promotie
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Quality assessment and multi modalty in gastric cancer treatment
Promotie
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Updates in Molecular Diagnosis and Targeted Treatment of Thyroid Neoplasia
Promotie
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Refining individualized treatment in older patients with breast cancer
Promotie
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Quantitative pharmacological modelling for optimizing treatment of sepsis
Promotie
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Exploring the mechanisms of metastatic onset for novel treatment strategies
Promotie
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Optimizing antifungal treatment through pharmacometrics: dosing considerations for enhanced efficacy
Promotie
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Discovery of BUB1 kinase inhibitors for the treatment of cancer
Promotie
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Strategies to optimise the treatment of community-acquired pneumonia
Promotie
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Harnessing zebrafish xenograft models for ocular melanoma treatment discovery
Promotie
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Regulation of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
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Preclinical validation of putative targets in cardiovascular and metabolic disease
Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
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Evaluatie en implementatie van innovatieve diagnostiek en behandelingen
Als een nieuwe methode is ontwikkeld om een (neuro-)psychologische aandoening of hieraan gerelateerde gedragsfactoren te herkennen en te behandelen, kan deze nog niet direct in de klinische praktijk worden ingezet. Eerst moet de methode geëvalueerd worden, bij voorkeur in gerandomiseerde, gecontroleerde…
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Using mouse models to uncover genes driving tumorigenesis and therapy resistance in human breast cancer
To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.
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Fundamenteel onderzoek: Onderliggende mechanisme van ziekte en welzijn
Om de juiste klinische beslissingen te nemen of effectieve diagnostische testen en behandelingen te kunnen ontwikkelen, is het belangrijk om de onderliggende mechanismen van een aandoening of een bepaald gedrag te begrijpen.
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Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
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Does it still hurt?
The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.
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Innovative (electro-driven) sample preparation tools for metabolomics study of muscle aging
This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.
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Evidence-based treatment of central serous chorioretinopathy
Promotie
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Class invariants for tame Galois algebras
Promotores: B. Erez, P. Stevenhagen, Co-Promotor: B. de Smit
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Self adjuvanting immunopeptides: Design and synthesis
Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.
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Patient readiness for shared decision making about treatment
Promotie
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Innovative diagnostics and treatments
Hoe meer we leren over een (neuro-)psychologische of lichamelijke aandoening en de hieraan gerelateerde gedragsfactoren, hoe beter we deze niet alleen kunnen signaleren, maar ook behandelen. Het is dus belangrijk dat recente inzichten over (neuro-)psychologische problemen en daaraan gerelateerde gedragsfactoren…
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Studies on molecular basics of metabolic syndrome in zebrafish
The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.
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of nanocarriers to improve the effectiveness of colorectal cancer treatment
Promotie
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Imaging of alkyne-functionalized ruthenium complexes for photoactivated chemotherapy
In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.
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Potentiation of Gram-positive specific antibiotics against Gram-negative bacteria through outer membrane disruption
Extending our current arsenal of antibiotics is key to staying ahead in the arms race between humans and resistant bacteria.
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Applications of multisource data-based dynamic modeling to cell-cell signaling and infectious disease spreading
The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…
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Photodynamic therapy-based combinations with immunotherapy in colon cancer treatment
Promotie
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In vitro models of bone-forming tumours: from target to treatment
Promotie
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signaling and inflammation: metabolomics for better diagnosis and treatment strategy
Promotie
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Patient derived zebrafish xenograft models for personalized treatment of uveal melanoma
Promotie
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Genomic driven treatment and drug rediscovery in patients with advanced cancer
Promotie
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PhD Candidate in Economics (0.8-1.0 fte)
Rechtsgeleerdheid
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Treatment optimisation and pharmacogenetics of systemic and intraperitoneal chemotherapy in colorectal cancer
Promotie
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Defining optimal oncolytic virus treatment and diagnostics in high risk melanoma patients
Promotie
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Treatment with anti-CGRP (receptor) antibodies for migraine: Can we predict effectiveness?
Promotie
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modeling of pharmacokinetics and tumor dynamics to guide anti-cancer treatment
Promotie
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Onderwerp: Placebo
De effecten van veel behandelingen worden in belangrijke mate bepaald door andere factoren dan het geneesmiddel of de behandeling zelf. Zo kunnen placebo-effecten even groot zijn als het effect van bijvoorbeeld antidepressiva of pijnstillers. Factoren die hieraan bijdragen zijn het vertrouwen in de…
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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Pharmacogenomics in drug development: implementation and application of PKPD model based approaches
Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh
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Small changes for long term impact: optimization of structure kinetic properties: a case of CCR2 antagonists
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman