220 zoekresultaten voor “equal treatment” in de Publieke website
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Yiatrosofia yia ton Anthropo: Indigenous Knowledge of Medicinal, Aromatic and Cosmetic (MAC) Plants in the Utilisation of the Plural Medical
Promotor: Prof.dr. L.J. Slikkerveer
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Pharmaceutical Aspects of Subvisible Particles in Protein Formulations
Promotor: W. Jiskoot, Co-promotor: A. Hawe
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Individualized dosing of serotherapy in allogeneic hematopoietic cell transplantation - a delicate balance
Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius
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The good? The bad? The mutant! Characterization of cancer-related somatic mutations and identification of a selectivity hotspot in adenosine
G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.
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Image analysis for gene expression based phenotype characterization in yeast cells
Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek
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Microengineered Human Blood Vessels For Next Generation Drug Discovery
Heart failure is a major health care problem with high mortality.
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Mechanisms of Ewing sarcoma metastasis
Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska
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Uncovering vulnerabilities in triple-negative breast cancer
Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.
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Invariant manifolds and applications for functional differential equations of mixed type
Promotor: S.M. Verduyn Lunel
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Novel regulators of prostate cancer stem cells and tumor aggressiveness
Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm
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B cell modulation in atherosclerosis
Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.
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Chemical tools to monitor and control proteasome activities
Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea
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Semisynthetic glycopeptide antibiotics
Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.
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Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
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Carcinogenicity of insulin analogues
Promotor: Prof.dr. B. van de Water
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Pharmacogenomics in Drug Development: Implementation and Application of PKPD Model Based Approaches
Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …
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Exploring chemical space in covalent and competitive glycosidase inhibitor design
Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency
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Immunity in atherosclerosis: novel assays, biomarkers and therapeutic approaches
Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.
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Development of life cycle assessment for residue-based bioenergy
Promotores: Prof.dr.G.R. de Snoo and Dr. R. Heijungs
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The role of zebrafish larvae for studying anxiety-like behaviour
The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.
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Ruthenium-peptide conjugates for targeted phototherapy
As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.
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Modulation of plant chemistry by rhizosphere bacteria
Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.
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From midplane to planets : the chemical fingerprint of a disk
This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.
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Dosing considerations for preterm neonates: from pharmacometrics to clinical practice
Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.
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Metabolomic characteristics of Catharanthus roseus plants in time and space
Promotor: R. Verpoorte, Co-promotores: Y.H.Choi, N.R. Mustafa
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Inhibitors and activity-based probes for β-D-glucuronidases, heparanases and β-L-arabinofuranosidases
Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.
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A pharmacognostic study of Vernonia guineensis Benth. (Asteraceae): bioactivity, safety, and phytochemical analysis
Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi
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Sensing Transport
Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.
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Novel detectors and algorithms for electron nano-crystallography
Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel
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Protein arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…
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Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
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Bioengineering and biophysics of viral hemorrhagic fever
Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…
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Activity-based protein profiling of glucosidases, fucosidases and glucuronidases
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea
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Concerns and opportunities related to discontinuation of treatment in rheumatoid arthritis
Promotie
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Bridging the gap, Pelvic floor physical therapy in the treatment of chronic anal fissure
Promotie
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Waste Collection Systems Assessed and Good Practices Identified (COLLECTORS)
What is the environmental impact of different waste collection systems across Europe? How can the collection be improved when considering collection, sorting, and treatment, as well as use options for secondary materials?
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From data to models: reducing uncertainty in benefit risk assessment: application to chronic iron overload in children
Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua
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Structural characterization of bacterial proteins involved in antibiotic resistance and peptidoglycan biosynthesis
This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.
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Novel pharmacometric techniques to quantify the pharmacodynamics of analgesics
The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.
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Learning from nature: using plant-soil feedback principles to improve growth and health of a horticultural crop
Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: M. Danhof, Co-promotor: E.C.M. de Lange
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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Lipids as therapeutic targets for barrier repair in skin diseases
The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.
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Evolutionary adaptability of β-lactamase: a study of inhibitor susceptibility in various model systems
β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…
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Policy Review on Decoupling
Development of indicators to assess decoupling of economic development and environmental pressure in the EU-25 and AC-3 countries.
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Publicaties
Disclaimer: Manuscripten die te maken hebben met het Resilience Center zijn alleen voor academische doeleinden en zijn niet bedoeld voor massaverspreiding of kopiëren. Raadpleeg de toepasselijke wetten voor eerlijk gebruik, inclusief de beperkingen van de houders van auteursrechten op publicaties.
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Open label placebo voor jeuk
Positieve verwachtingen kunnen het gevoel van jeuk beïnvloeden en placebo-effecten oproepen, terwijl negatieve verwachtingen nocebo-effecten bij jeuk kunnen veroorzaken. Er zijn aanwijzingen dat placebo-effecten ook kunnen optreden wanneer mensen weten dat zij een placebo innemen. Er is weinig bekend…
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Development of life cycle assessment for residue-based bioenergy
Wat zijn de belangrijkste thema's in het uitvoeren van systemen voor bio-energie ?
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Onderwerp: Psychologische factoren bij jeuk en pijn
Aangezien jeuk en pijn zeer belastend kunnen zijn, vooral wanneer mensen chronisch aan (een van) deze symptomen lijden, is het belangrijk te weten door welke factoren deze gewaarwordingen worden beïnvloed. Het wordt steeds duidelijker dat psychologische factoren een belangrijke rol spelen bij het ervaren…
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Wetenschappers
Leidse wetenschappers onderzoeken de wereld om ons heen en geven hun kennis door aan toekomstige generaties. Zij geven gezicht aan de universiteit, ieder met zijn of haar individuele expertise en persoonlijke fascinatie voor het eigen vakgebied.