Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

The soil ecosystem consists of the largest reservoir of biodiversity on Earth.

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

Promotor: P.M. Brakefield

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

As a contribution to the changing legislation and evolving societal attitudes concerning environmental issues, this project aims to enhance and manipulate the plants’ own natural defense mechanisms against western flower thrips (WFT).

The plant hormone auxin plays a central role in the growth and development of plants. Auxin acts in a concentration dependent manner and polar cell-to-cell transport of this hormone determines its distribution in the tissues of plants. This polar auxin transport is mediated by several families of auxin…

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

The plant hormone auxin regulates plant growth and development through polar cell-to-cell transport-generated maxima and minima. PIN FORMED (PIN) auxin efflux carriers determine the direction of this auxin flow through their asymmetric placement on the plasma membrane (PM).

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

Prof.dr. J. Memelink

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.

Niet alleen bij pubers lijken hormonen de baas. Ook bij insecten spelen ze een cruciale rol in het afstemmen van gedrag, groei en voortplanting op externe omstandigheden. Zo heeft voortplanten weinig zin in een seizoen van voedselschaarste, omdat dan nakomelingen een slechte start zullen maken. Een…

Veel leefomgevingen op aarde veranderen drastisch met de seizoenen. Voor dieren in deze seizoensgebonden omgevingen heeft dit grote invloed op de beschikbaarheid van voedsel, hoeveelheid roofdieren en mogelijkheden om voort te planten. Om zich in dit soort habitatten succesvol te handhaven moeten dieren…

Een verhoudingsgewijs grote hoeveelheid testosteron bij jongens zorgt voor sensatiezucht en roekeloosheid, bij meisjes juist voor meer zelfbewustheid en minder jaloezie en opgekropte woede. Dat is een van de conclusies van de Leidse psycholoog Jiska Peper uit haar Veni-onderzoek naar impulscontrole…