Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. M. van der Zee

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

Promotor: Prof.dr. J.N. Kok

Promotie

The overall objectives of my thesis are to investigate the dynamics of the sorghum root microbiome and to explore the beneficial effects of the root microbiome on sorghum growth and stress tolerance.

Promotores: J. Jonkers, K.E. de Visser

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf

This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.

This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.

Control of infectious diseases poses continuous challenges for human health.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

Chiodo

Promotie

We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.

In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

On 12 September 2019, Judge Chile Eboe-Osuji, President of the International Criminal Court (ICC), delivered a lecture on Customary International Criminal Law and Head of State Immunity to open the academic year for the Advanced LL.M. Programmes in Public International Law & International Dispute Settlement…

Het immuunsysteem beschermt ons tegen ziekten, maar soms gaat het mis. Dan dringt er toch een vijand binnen of valt het immuunsysteem ons eigen lichaam aan, waardoor we ziek worden. Artsen en onderzoekers van het Leids Universitair Medisch Centrum (LUMC) willen het immuunsysteem zodanig sturen, dat…

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

Het huidige TBC-vaccin biedt niet voldoende bescherming meer. Een Europees consortium gaat daarom proberen een nieuw vaccin te ontwikkelen. Hiervoor ontvangen zij een Horizon2020-subsidie van 18 miljoen euro. Bijna een miljoen euro hiervan gaat naar het LUMC.

Promotie

The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.

Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert

Promotores: H.A. Udo De Haes, P.M. Brakefield

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.

Het LUMC staat als innovator voor het verbeteren van de gezondheidszorg en de gezondheid van mensen. Dat is onze missie. Dit doen we vanuit toonaangevend onderzoek en vernieuwend onderwijs.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

Promotors: Prof.dr. G.R. de Snoo, Prof.dr. H. Leirs (Univ. Antwerpen)

Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst

This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

The soil ecosystem consists of the largest reservoir of biodiversity on Earth.

Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.

Remus Dame

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez