3,198 zoekresultaten voor “mathematical and statistical modelling” in de Publieke website
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Gibbs-non-Gibbs transitions and vector-valued integration
Promotor: W. T. F. den Hollander, F. H. J. Redig
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UD Medical Statistics
Wiskunde en Natuurwetenschappen, Mathematisch Instituut (MI)
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Statistical modelling of time-varying covariates for survival data
Promotie
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Ecology and genomics of Actinobacteria and their specialised metabolism
Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.
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Discovering the preference hypervolume: an interactive model for real world computational co-creativity
In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.
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Vaccination and Targeted Therapy Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
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Concepts and applications for evidence-based dosing in morbidly obese patients before and after weight loss surgery
Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst
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Het gebruik van een praktisch didactisch model door beginnend docenten voor het leren ontwerpen van lessen
Beginnend docenten hebben vaak moeite met het maken van activerende lessen. In dit onderzoek wordt gekeken hoe het didactisch bouwstenen model hen een helpende hand kan bieden bij het leren ontwerpen van lessen.
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The Chara plasma membrane system : an ancestral model for plasma membrane transport in plant cells
Multicellular giant algae Chara species have been widely used in physiological studies for decades.
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Quantum local asymptotic normality and other questions of quantum statistics
Promotor: R. Gill, Co-promotor: P. Massart
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Model-assisted robust optimization for continuous black-box problems
Uncertainty and noise are frequently-encountered obstacles in real-world applications of numerical optimization. The practice of optimization that deals with uncertainties and noise is commonly referred to as robust optimization.
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Intermittency and Number Expansions for Random Interval Maps
This dissertation consists of two parts, each of which considers a different research area related to random interval maps. In the first part we are interested in random interval maps that are critically intermittent.
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pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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Towards circular and energy-efficient management of building stock
Material circularity and energy efficiency are highly relevant and intertwined issues for the transition towards a carbon-neutral and circular built environment. In the Netherlands, the building sector has been rendered a priority towards a circular and low-carbon society.
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adaptability of β-lactamase: a study of inhibitor susceptibility in various model systems
β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…
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Dynamical Gibbs-non-Gibbs transitions and Brownian percolation
Promotor: Prof.dr. W.Th.F. den Hollander, Co-promotor: R. Fernandez.
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NMR studies of protein-small molecule and protein-peptide interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
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Scalability and uncertainty of Gaussian processes
The main theme of this thesis is the theoretical study of Gaussian processes as a tool in Bayesian nonparametric statistics.
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maximising approaches to evaluate the trade-offs involved in the evergreen and deciduous conundrum
Which traits and/or trade-offs determine benefits of being deciduous or evergreen?
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Lasers, lenses and light curves: adaptive optics microscopy and peculiar transiting exoplanets
Promotores: Prof.dr. C.U. Keller, Prof.dr. H.C. Gerritsen
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Zebrafish xenograft model: identification of novel mechanisms driving prostate cancer metastasis
Prostate cancer (PCa) is one of the most prevalent cancer in males.
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Gerard van Westen: 'Ons model voorspelt wat kandidaat-medicijnen doen in je lijf'
Hij praat snel en enthousiast. Logisch, want Gerard van Westen is als de machinist op een heel snelle trein. Het eindstation: een virtuele mens, bestaand uit algoritmen die voorspellen wat een toegediende stof doet in ons lichaam. De trein is al een heel eind op weg. De farmaceutische industrie is ook…
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Solving multiplication and division problems
Latent variable modeling of students' solution strategies and performance
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Probing new physics in the laboratory and in space
The Standard Model (SM) of particle physics fails to explain several observed phenomena and is incomplete. In order to resolve this problem, one may extend the SM by adding new particles.
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Drie Leidse wiskundigen benoemd tot Fellow van de American Mathematical Society
Manjul Bhargava, Frank den Hollander en Hendrik Lenstra zijn toegetreden tot de ‘Inaugural Class of AMS Fellows’ van het ‘Fellows of the American Mathematical Society program’.
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G-zips and Ekedahl-Oort strata for Hodge type Shimura varieties
Promotores: S.J. Edixhoven, F. Andreatta
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Repackaging in South–North Policy Learning: The Chilean Model of Pension Reform as a Lopsided Exportschlager
In dit artikel vatten Kristin Makszin en Achim Kemmerling bewijs samen over hoe het VK en de VS leren van het Chileense pensioenmodel, maar beide landen slagen er niet in krediet toe te kennen of de lessen te vervormen.
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Topics in the arithmetic of del Pezzo and K3 surfaces
Promotores: P. Stevenhagen, L. van Geemen (Università degli studi di Milano), Co-Supervisor: Ronald M. van Luijk
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Me, My Fiends, and I
A neuro-ecological perspective on adolescent prosocial development
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Semi-partitioned Scheduling and Task Migration in Dataflow Networks
Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov
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Understanding membrane fusion at the molecular level using a biomimetic model system
Kros
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Fermions and Bosons: Excitons in strongly correlated materials
Promotors: Prof.dr. J. Zaanen, Prof.dr.ir. H. Hilgenkamp
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Metals, energy and geopolitics, a complex mix
Lezing, Tuesday Talks: Science Insights
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Exploration on and of Networks
This dissertation consists of two parts, with the common theme
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representation in Multi-sensor Earth Observation Products through phenology and trait-based priors
What are the behaviours of plant traits throughout various points in the growing season in a radiative transfer model framework and how well can this knowledge be integrated through data assimilation to provide priors for robust local and global vegetation products and analysis?
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Distance-based analysis of dynamical systems and time series by optimal transport
Promotor: S.M. Verduyn Lunel
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Accurate modeling of the dynamics of dissociative chemisorption on metal surfaces
Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.
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Interaction with sound for participatory systems and data sonification
This thesis deals with the use of sound in interactions in the context of participatory systems and data sonification. We investigate an interactive environment where participants perceive information of the data through sound elements.
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Dormancy in stochastic interacting systems
Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.
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Clavis Aurea? Structure-enabled approaches of identifying and optimizing GPCR ligands
Promotores: A.P. IJzerman, H.W.T. van Vlijmen
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Data Science and Artificial Intelligence (BSc)
Bij Data Science & Artificial Intelligence leer je hoe je functies van het brein, zoals denken, geheugen, leren en aandacht in modellen kunt gieten. Deze kennis kun je gebruiken om computers en systemen op vergelijkbare of betere manieren te laten functioneren.
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Software and AI in Business
Software and AI in Business (S&B) verbindt de domeinen wetenschap, bedrijfsleven en beleid. Wetenschappelijk onderzoek waar we ons in Leiden op richten, bijvoorbeeld op het gebied van kunstmatige intelligentie, belooft onze samenlevingen ten goede te komen. Het vertalen van wetenschap naar positieve…
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Electrical and magnetic properties of ferritin: electron transport phenomena and electron paramagnetic resonance
Ferritin is a spherical metalloprotein, capable of storing and releasing iron in a controllable way. It is composed of a protein shell of about 12 nm and within its cavity, iron is stored in a mineral form.
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Multi-dimensional feature and data mining
In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.
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Data science for tax administration
In this PhD-thesis several new and existing data science application are described that are particularly focused on applications for tax administrations.
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Multiple star formation: chemistry, physics and coevality
Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.
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Evolutionary diversification and historical biogeography of Orchidaceae in Central America with emphasis on Costa Rica and Panama
In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.
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Patterns on Spatially Structured Domains
We consider the propagation of electrical signals through nerve fibres.
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Stereoelectronic and conformational effects in oxocarbenium, iminium and iminosugar ammonium ions
Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée