During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.

Several techniques are explored for going beyond the born-oppenheimer static surface model for molecule-surface reactions.

In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.

Promotors: Prof.dr. J. Zaanen, Prof.dr.ir. H. Hilgenkamp

This thesis is a collection of theoretical works aiming at adjusting quantum algorithms to the hardware of quantum computers.

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

Beginnend docenten hebben vaak moeite met het maken van activerende lessen. In dit onderzoek wordt gekeken hoe het didactisch bouwstenen model hen een helpende hand kan bieden bij het leren ontwerpen van lessen.

Promotor: Prof.dr. M.K. Richardson

Uncertainty and noise are frequently-encountered obstacles in real-world applications of numerical optimization. The practice of optimization that deals with uncertainties and noise is commonly referred to as robust optimization.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

Promotores: Prof.dr. J. Schaye & Prof.dr. C. Steidel (California Institute of Technology)

Hij praat snel en enthousiast. Logisch, want Gerard van Westen is als de machinist op een heel snelle trein. Het eindstation: een virtuele mens, bestaand uit algoritmen die voorspellen wat een toegediende stof doet in ons lichaam. De trein is al een heel eind op weg. De farmaceutische industrie is ook…

Prostate cancer (PCa) is one of the most prevalent cancer in males.

In the first part, we introduce a new condition, called toric-additivity, on a family of abelian varieties degenerating to a semi-abelian scheme over a normal crossing divisor.

This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.

In dit artikel vatten Kristin Makszin en Achim Kemmerling bewijs samen over hoe het VK en de VS leren van het Chileense pensioenmodel, maar beide landen slagen er niet in krediet toe te kennen of de lessen te vervormen.

Kros

Cardiovascular diseases are still a major concern for the global health.

Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.

Chapter 1,contains the numerical verification of the Birch and Swinnerton-Dyer conjecture for hundreds of Jacobians of hyperelliptic curves of genus 2, 3, 4 and 5.

Hot astrophysical plasma is ubiquitous in the Universe, from comets in our Solar system to the largest scale structures -- the cosmic web filaments. These hot plasmas, with the temperature of a few millions of degrees, are often observed in the X-ray wavelength range.

Op 6 juni 2019 verdedigde Edward Donelan zijn proefschrift 'Regulatory Management Policies and a Universal Model for Public Policy Making, Legislative Drafting and Managing Stocks of Legislation'. Het promotieonderzoek is begeleid door promotor prof. W.J.M. Voermans.

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

Promotor: J. A. Bouwstra

Vast, often populated, areas in dryland ecosystems face the dangers of desertification.

Supervisor: S.F. Portegies Zwart Co-Supervisor: A.G.A. Brown

This thesis covers various applications of topology in condensed matter physics and quantum information.

One of the effects of climate change is the phenomenon of desertification, a process that occurs in semi-arid and arid areas and causes land degradation as well as vegetation loss. Due to the lack of resources, vegetation self-organizes to sustain itself by forming large-scale spatial patterns.

We investigate the buildup of galaxies from various vantage points. The first two chapters focus on the stellar content of galaxies, especially the distribution of stellar masses at birth and potential variations therein in various galactic environments.

Elektrische signalen bewegen als een golf door onze zenuwbanen. De wiskundige modellen voor deze bewegingen konden nog niet alle biologische eigenschappen van de zenuwbanen goed beschrijven. Promovendus Willem Schouten-Straatman bracht hier verandering in door de bestaande modellen te verbeteren. 'Ik…

Promotor: H.J.M. de Groot

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

Promotor: Prof.dr. V. Icke, Co-Promotor: T.I. Madura

Galaxies form and evolve through close interaction with their surroundings. As a result, the heavy elements ('metals') that are synthesized in stars, are found both inside and outside galaxies.

Galaxies in the local Universe fall into two main categories of spirals and ellipticals. In this Thesis, we explore the structural evolution of galaxies into this bimodal distribution.

This thesis covers several aspects of quantum algorithms for near-term quantum computers and its applications to quantum chemistry and material science.

This thesis provides an overview of the development of the Pair Configuration to Molecular Activity Coefficient (PAC-MAC) model.

Like a mixture of oil and water, lipid membranes separate into two liquid phases.

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Matthijs van Leeuwen van het Leiden Institute of Advanced Computer Science ontwikkelt methodes om interactief naar de juiste computermodellen te zoeken. Hierbij kunnen experts informatie uit ruwe data combineren met hun eigen kennis om zo voorspellingen accurater te maken. ‘Op deze manier hopen we modellen…

Komen medicijnen in de juiste hoeveelheid aan op de juiste plek in ons brein? Door een model te maken dat ons brein in kleine ‘hersenblokjes’ weergeeft, probeert Esmée Vendel hier een antwoord op te vinden. Haar nieuwe, wiskundig model voorspelt de medicijnconcentratie in de hersenen over tijd én ruimte.…

De huidige en toekomstige quantumcomputers vormen dezelfde uitdaging als de laser in zijn begindagen. In theorie werd voorspeld dat de laser een bron van zeer speciaal, zeer krachtig licht zou zijn. Maar in die tijd waren er geen duidelijke toepassingen voor. Critici van het idee noemden het een probleem…

De Leidse promovendus Sreenivasa Ramaiahgari ontwikkelde voor het eerst een 3D-model van de lever. Zijn model kan een hoop besparen: schade bij patiënten, dierenleed en veel geld. Promotie 4 juni.

The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.

Mechanical interactions between cells and their environment play an important role in many biological processes.

In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.