217 zoekresultaten voor “cancer immunotherapy” in de Publieke website
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Harnessing zebrafish xenograft models for ocular melanoma treatment discovery
The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…
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Caging ruthenium complexes with non-toxic ligands for photoactivated chemotherapy
The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.
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Carcinogenicity of insulin analogues
Promotor: Prof.dr. B. van de Water
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Role of integrin adhesions in cellular mechanotransduction
Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen
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Computational modeling of cellular dynamics in tumor cell migration
Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.
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Visualization of Vitamin A Metabolism
Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.
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The Metallophilic Interaction between Cyclometalated Complexes: Photobiological Applications
In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.
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Haico van Attikum
Faculteit Geneeskunde
h.van.attikum@lumc.nl | +31 71 526 9624
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Modulating the behaviour of pancreatic tumour cells
Promotores: Prof.dr. M.K. Richardson, Prof.dr. H.P. Spaink. Co-promotor: C.P. Bagowski
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Functions of P38 and ERK kinases in zebrafish early development
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar
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Immunotherapy in advanced melanoma - crossing borders
Promotie
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Transfusion Medicine and Cellular and Tissue Therapies (MSc)
This joint Master with the Autonomous University of Barcelona will the equip you with the necessary competences to play a key role in the emerging field of transfusion medicine. The programme includes both transfusion of blood components and hematopoietic transplants, cellular and tissue therapy, and…
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Improving immunotherapy for melanoma: models, biomarkers and regulatory T cells
Promotie
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immunostimulatory properties of oncolytic reovirus for anticancer immunotherapy
Promotie
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Op weg naar kankervaccins op maat
Kanker bestrijden door gebruik te maken van de DNA-foutjes die tot het ontstaan van de tumor hebben geleid: dat willen onderzoekers van het Leids Universitair Medisch Centrum (LUMC) en de Universiteit Leiden.
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Multilayer cancer glycomis
Promotie
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Lighting Up Cancer Aggressiveness
Promotie
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Radiotherapy for endometrial cancer
Promotie
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The role of the tumor suppressor Lkb1 in energy homeostasis
The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.
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Stromal immunobiology in gastrointestinal cancer
Promotie
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Tumoren trekken bloedvaten aan met ‘afstandsbediening’
Onderzoekers van de Universiteit Leiden hebben aangetoond dat tumoren op een mechanische manier bloedvaten kunnen aantrekken, waardoor ze kunnen groeien. Het team publiceerde deze ontdekking op 2 maart in Nature Scientific Reports.
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In vivo modelling of Ewing sarcoma in zebrafish
Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska
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Ruim 700.000 euro voor de strijd tegen agressieve borstkanker
Eiwitten remmen die een rol spelen bij de groei van agressieve kankercellen, dat is het plan van professor Bob van de Water en zijn team. Zij ontvangen hiervoor ruim 700.000 euro van KWF Kankerbestrijding. Onderzoeker Maaike Vreeswijk en patholoog Danielle Cohen zijn aangesloten vanuit het LUMC.
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EGFR inhibitors in colorectal cancer
Promotie
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Targeting SUMO Signaling to Wrestle Cancer
Promotie
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The path to individualised breast cancer screening
Promotie
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Raman Spectroscopy in Bladder Cancer Diagnosis
Promotie
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Monitoring Outcomes In Colorectal Cancer Surgery
Promotie
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Glycoproteomics assays for prostate cancer biomarker discovery
Promotie
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Identification of regulators of cancer - immune interactions
Promotie
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Dissecting the immune microenvironment of breast cancer
Promotie
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Lateral Lymph Nodes in Rectal Cancer
Promotie
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Formulation of Peptide-Based Cancer Vaccines
Promotie
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Tailored treatment for colon and rectal cancer
Promotie
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Genetic and lifestyle factors in breast cancer prognostication
Promotie
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Prediction of contralateral breast cancer - Statistical aspects and performance assessment
Promotie
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Everyone works better together:Rational improvements to radio- and immunotherapy combinations
Promotie
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Immuno-photodynamic therapy of cancer
Promotie
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Experimental optical imaging during pancreatic cancer interventions
Promotie
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Optimizing clinical management of T1 colorectal cancer
Promotie
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Harnessing neoantigens for targeted cancer treatment
Promotie
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How to develop cancer drugs with less side effects
Lezing, Tuesday Talks: Science Insights
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Click-to-release for immune cell activation
This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…
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Mechanisms of Ewing sarcoma metastasis
Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska
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Leukemia treatment & cognitive development
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Fluorescence Polarization Activity-Based Protein Profiling on Retaining Glycosidases
Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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Ruthenium-peptide conjugates for targeted phototherapy
As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.
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Inhibitors and activity-based probes for β-D-glucuronidases, heparanases and β-L-arabinofuranosidases
Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.
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Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt