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Students with learning problems experience difficulties in reading, writing, and content-area learning into and throughout their secondary-school years

Dit proefschrift beschrijft de ontwikkeling van een beoordelingsprocedure voor docenten, toegespitst op beginnende eerstegraads docenten Engels.

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

Promotor: Prof.dr. B. van de Water

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

Op 30 september 2021 verdedigde Babette van Hazebroek haar proefschrift 'Understanding delinquent development from childhood into early adulthood in early onset offenders'. Het promotieonderzoek is begeleid door promotoren prof.dr. J.W. de Keijser en prof. dr. A. Popma (VUMC).

This study attempts to understand how indigenous community institutions pose an important role in sustainable community-based development, including the integration between local culture and development.

Dit proefschrift omvat vier deelstudies waarin de ‘pedagogische vakkennis’ (pedagogical content knowledge ofwel PCK) van bètadocenten wordt onderzocht.

There is an increasing amount of attention on EU and its Member States contributions to implementation of two landmark agreements: the Paris Climate Agreement and the UN Agenda 2030 with Sustainable Development Goals (SDGs). Absent from the current literature is an analysis of the political effect of…

Promotor: Prof.dr. J.N. Kok

Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).

Het terugdringen van agressie is in de afgelopen jaren in toenemende mate een maatschappelijke prioriteit geworden. Agressie in de vroege kindertijd vergroot de kans op latere agressieproblemen en antisociaal gedrag.

In dit onderzoek wordt hersenontwikkeling voor het eerst direct gelinkt aan sekseverschillen en schoolprestatie. De resultaten ontkrachten de mythe dat jongens achterlopen in hersenontwikkeling.

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

Docenten in het hoger onderwijs zijn experts in wát zij doceren, maar niet noodzakelijk in hóe zij dit zouden moeten doen. Dit komt omdat zij vaak weinig tot geen training hebben gehad in het lesgeven. Daarnaast zijn zij over het algemeen meer georiënteerd op hun eigen vakgebied dan op hun rol als docent.…

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

Heart failure is a major health care problem with high mortality.

Promotor: Prof.dr. J. Kuiper

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.

Emoties en de psychosociale ontwikkeling van kinderen met en zonder Taal Ontwikkelingsstoornis

In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Hoogleraar Annemarie Meijer en dr. Sander Wezenberg ontvingen op 24 januari een NWO-subsidie voor hun onderzoek. De subsidie is toegekend binnen het Open Competitie ENW-M-programma en is bedoeld voor vernieuwende onderzoeksgebieden die de basis kunnen zijn voor onderzoeksthema’s van de toekomst.

De Edinburgh Medal 2016 is uitgereikt aan zowel Kevin Govender van de Office of Astronomy for Development (OAD) als de International Astronomical Union (IAU). De prijs is een erkenning voor het wereldwijd bevorderen van onderwijs en technologie door middel van sterrenkunde. Het programma is het geesteskind…

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri

Waarom zijn mycobacteriën zulke succesvolle ziekteverwekkers? En zijn er verdedigingsmechanismen in het lichaam die helpen een infectie iets te verminderen? Om dit te achterhalen, heeft Annemarie Meijer de NWO Open competitie ENW-XL-beurs toegekend gekregen. Ze gaat niet alleen aan de slag. Aan het…

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

Dit proefschrift gaat over de invloed van inductieprogramma’s op het welbevinden en de professionele ontwikkeling van beginnende docenten, en welke specifieke kenmerken van inductieprogramma’s daarvoor belangrijk zijn. Hiernaar is onderzoek gedaan met een interviewstudie en een grootschalige vragenl…

The aim is to develop methods to assess environmental and occupational exposure to (individual) pesticides, to be applied in epidemiological studies investigating pesticide exposure and human health. Furthermore, we aim to investigate the potential association between exposure to pesticides and Parkinson’s…

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

This research delves into the unique cultural approach of the Tenggerese people, an Indigenous community in East Java, Indonesia, regarding elderly care. It focuses on their traditional practices of bakti (‘filial piety’) and sayan (‘mutual aid’), deeply ingrained in the community's lifestyle and va…

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot

Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

Promotor: Prof.dr. R.M.H. Merks

In deze studie wordt verslag gedaan van een onderzoek naar de ontwikkeling van de praktijkkennis bij elf docenten Nederlands. Zij ontwikkelden en implementeerden concept-contextrijk onderwijs met behulp van actieonderzoek.

Leidse wiskundig biologen hebben een model ontwikkeld dat helpt verklaren hoe onder meer de ruggengraat en de wervels ontstaan in de embryonale ontwikkeling. Hetzelfde proces, maar dan andersom, speelt een sleutelrol bij de uitzaaiing van kanker. Publicatie in iScience.

In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Machine Learning is becoming a more and more substantial technology for industry.

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

Cardiovascular disease is the leading cause of death worldwide.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.