1,192 zoekresultaten voor “development disease” in de Publieke website
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Towards a Sustainable and Circular Metals Economy
In-use stocks of products can be considered as intermediaries between human needs and the physical world.
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Force sensing and transmission in human induced pluripotent stem-cell-derived pericytes
Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.
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System-level design for efficient execution of CNNs at the edge
A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.
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The diverse roles of integrin α3β1 in cancer: Lessons learned from skin and breast carcinogenesis
In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.
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Natural and non-natural factors influencing Alzheimer´s Aβ
Promotor: Prof.dr. J.P. Abrahams
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Replacing the needle and syringe for vaccine administration
Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra
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Core cross-linked polymeric micelles based on polypept(o)ides: from secondary structure formation of polypeptides to functional cross-linking
This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.
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Human Evolution
This multidisciplinary minor provides students with knowledge on how and why humans became the way they are. The minor focuses on the evolution of the species Homo sapiens from other hominin lineages and animal ancestors, and on the various factors shaping this process. Not only is human evolution of…
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Verkenning van islamisering
Kunnen we spreken van één enkel islamitisch discours op gebieden zoals politiek, strijd, economie en duurzame ontwikkeling? En welke interactie bestaat er tussen dit islamitisch denken en 'westers' denken?
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Helft jonger, evenveel inzicht
Je zou denken dat 12-jarigen meer weten over drijven en zinken dan 6-jarigen. Uit onderzoek blijkt echter dat de individuele verschillen in inzicht erg groot zijn. Sommige 6-jarigen hebben een beter natuurkundig inzicht dan 12-jarigen.
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Kernteam
Het kernteam van het PDC is verantwoordelijk voor onderzoek en ontwikkeling van de LMW-methode en voert het beheer van de LMW trajecten binnen de verschillende deelnemende instellingen.
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Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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First-pass and systemic metabolism of cytochrome P450 3A substrates in neonates, infants, and children
Growth and development affect the metabolism of drugs administered to neonates, infants, and children.
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Targeting of antigen-presenting cells with mannosylated conjugates
This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.
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Europa en de sociaal-economische kracht van astronomie
Het European Regional Office of Astronomy for Development (E-ROAD) heeft zijn eerste conferentiesessie gehouden tijdens de virtuele EAS Annual Meeting 2020, de grootste astronomieconferentie in Europa. E-ROAD is een initiatief van de Internationale Astronomische Unie en de Universiteit Leiden. Het zet…
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Photo-activation of ruthenium-decorated upconverting nanoparticles
Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).
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SCS Courses
The coursework within the Science Communication and Society (SCS) specialisation prepares students for internships and a career in communication about science and health.
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Using mouse models to uncover genes driving tumorigenesis and therapy resistance in human breast cancer
To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.
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Targeting Human Proteasomes: Substrates, Inhibitors and Prodrugs
Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.
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Iber Kasehatan in Sukamiskin: Utilisation of the Plural Health Information and Communication System in the Sunda Region of West Java, Indonesia
This study has been carried out in the community of Sukamiskin, a kelurahan (‘village’) in Bandung, the Capital of West Java Province, located in the Sunda Region of Indonesia.
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Lecture Series | Novel approaches to delay ageing and age-related diseases
Lezing, Lezing onderdeel van serie
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Nieuw project om ziekte van Alzheimer te bestuderen
Onderzoekers van de Universiteit Leiden gaan een nieuwe manier ontwikkelen om de biomarkers van de ziekte van Alzheimer te bestuderen. De aanpak focust zich op de moleculaire boodschappers van de cellen. Het project, geleid door Thomas Hankemeier en gecoördineerd door Yuliya Shakalisava (Leiden Academic…
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Unfolding the regulation of stress response pathways upon liver injury
Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.
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High-throughput profiling of small molecules using mass spectrometry
Promotor: Prof.dr. T. Hankemeier
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Functional characterization and unraveling the Gene Regulatory Networks (GRNs) of HD-Zip transcription factor HB40 (and HB22) in Arabidopsis
In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.
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Contact
Heb je nog vragen over de masterspecialisatie Digital Media in Human Development? Neem dan gerust contact met ons op!
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Contact
Heb je nog vragen over de masterspecialisatie Parenting and Child Development? Neem dan gerust contact met ons op!
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Contact
Heb je nog vragen over de masterspecialisatie Applied Neuroscience in Human Development? Neem dan gerust contact met ons op!
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Mitochondria in chemical-induced toxicity
Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…
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Education and Child Studies (MSc)
In de masteropleiding Education and Child Studies kies je een specialisatie in één van de deeldisciplines van de pedagogische wetenschappen. In alle specialisaties staat de wetenschappelijke vorming van studenten voorop.
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Toelatingseisen
De masteropleiding Education and Child Studies is een academische opleiding en biedt op onderzoek gebaseerde kennis over leren en de ontwikkeling van kinderen.
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Toelatingseisen
De masteropleiding Education and Child Studies is een academische opleiding en biedt op onderzoek gebaseerde kennis over leren en de ontwikkeling van kinderen.
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Toelatingseisen
De masteropleiding Education and Child Studies is een academische opleiding en biedt op onderzoek gebaseerde kennis over leren en de ontwikkeling van kinderen.
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Toelatingseisen
De masteropleiding Education and Child Studies is een academische opleiding en biedt op onderzoek gebaseerde kennis over leren en de ontwikkeling van kinderen.
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Toelatingseisen
De masteropleiding Education and Child Studies is een academische opleiding en biedt op onderzoek gebaseerde kennis over leren en de ontwikkeling van kinderen.
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Preclinical therapy development in FSHD
Promotie
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Genetic and clinical pharmacology studies in GBA1-associated Parkinson's disease
Promotie
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in acute myocardial infarction and the assessment of valvular heart disease
Promotie
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Advanced tools and methods for modeling cardiovascular disease using human pluripotent stem cells
Promotie
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Targeting autoimmunity in renal diseases: focus on neutrophil extracellular traps and autoreactive B-cells
Promotie
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Aortic valve disease: multimodality imaging for risk stratification and evaluation of therapy
Promotie
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Urbanization in Indonesia and Its Impact on Non-communicable Diseases
Promotie
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Optimising neonatal management of haemolytic disease of the foetus and newborn
Promotie
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Based Pituitary Care, implementing Value Based Health Care in a rare disease
Promotie
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Multi-modality imaging in ischemic heart disease, arrhythmia and cardiac-mechanics
Promotie
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closer look: Non-invasive tools for in-depth characterisation of vulvar diseases
Promotie
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Specifiek eiwit in de hoofdrol bij ziekte van Parkinson
Met elektronspins hebben natuurkundigen het bindingsproces onderzocht van het eiwit α-synucleïne, dat wordt geassocieerd met de ziekte van Parkinson. Wat blijkt is dat het eiwit op een verrassend efficiënte manier bindt aan een hersenmembraan. Met deze in Leiden ontwikkelde methode hebben de onderzoekers…
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Onderwijs
De vakken die het VVI aanbiedt zijn onderdeel van het bredere onderwijsprogramma van de Faculteit der Rechtsgeleerdheid, dat programma’s aanbiedt op bachelor- (LLB) en masterniveau (LLM, Advanced Studies, PhD). Het instituut geeft een in Europa uniek MSc programma Law and Society: Governance and Global…
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Synthesis of well-defined ADP-Ribosylated biomolecules
Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov