275 zoekresultaten voor “genome organization” in de Publieke website
-
Antibiotic Discovery: From mechanistic studies to target ID
The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.
-
Group benefits from genomic instability: a tale of antibiotic warriors in Streptomyces
Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.
-
Exploring Grainyhead-like 2 target genes in breast cancer
The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.
-
Hybrid zone dynamics in amphibians
Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.
-
Global Leadership Centres Roundtable
Het Leiden Leadership Centre is lid van de Global Leadership Centres Roundtable (GLCR). De Global Leadership Centres Roundtable is het internationale netwerk van universitaire leiderschapscentra.
-
Understanding the Heterogeneity of Corporate Entrepreneurship Programs
In today's volatile market environments, companies must be able to continuously innovate. In this context, innovation does not only refer to the development of new products or business models but often also affects the entire organization, which has to transform its structures, processes, and ways of…
-
Kampioen in koolhydraatchemie: Hermen Overkleeft wint prestigieuze prijs
Professor Hermen Overkleeft ontvangt de prestigieuze Roy L. Whistler International Award 2024 van de International Carbohydrate Orgasation. De prijs is een erkenning voor Overkleefts bijdrage aan de koolhydraat- en biochemie.
-
Spatiotemporal Organization of Organelles through Membrane Contact Sites
Promotie
-
Discovery of novel Antibiotics from Actinomycetes by Integrated Metabolomics & Genomics Approaches
Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi
-
Mechanisms and consequences of horizontal gene transfer in cell wall-deficient cells of Kitasatospora viridifaciens
The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…
-
Self adjuvanting immunopeptides: Design and synthesis
Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.
-
Vervolgopleidingen
Door het volgen van een master vergroot je je kansen op de arbeidsmarkt. Na de driejarige bachelor kun je direct doorstromen naar een één- of tweejarige master bij de Universiteit Leiden of een andere instelling.
-
Vervolgopleidingen
Door het volgen van een master vergroot je je kansen op de arbeidsmarkt om een baan op niveau te vinden. Na de driejarige bachelor kun je direct doorstromen naar een één- of tweejarige master bij de Universiteit Leiden of een andere instelling.
-
Vervolgopleidingen
Door het volgen van een master vergroot je je kansen op de arbeidsmarkt om een baan op niveau te vinden. Na de driejarige bachelor kun je direct doorstromen naar een één- of tweejarige master bij de Universiteit Leiden of een andere instelling.
-
Rituals of Birth, Circumcision, Marriage, and Death among Muslims in the Netherlands
Migration imposes special pressures on the meaning, experience and organization of lifecycle rituals. These pressures are felt most strongly by Muslim migrants to Western Europe. In this innovative study, Nathal M. Dessing examines the effects of migration on the life cycle rituals of Moroccan, Turkish…
-
Force sensing and transmission in human induced pluripotent stem-cell-derived pericytes
Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.
-
Studie-informatie van alle vakken
Ons onderwijsaanbod is breed en divers. Hieronder vindt u alle informatie over de vakken die door de afdeling Bedrijfswetenschappen worden verzorgd. Als u op een vak klikt, wordt u doorgeleid naar de studiegids.
- Postdoctoral Researcher on the Adaptive Capacities of States to Transboundary Crises
-
determinants of effective eHealth: high-quality applications and optimal organization
Promotie
-
[sbb] INSCONS: International Scientific Consortia
Wereldwijde uitdagingen aanpakken via internationale wetenschappelijke consortia
-
Development of automatic image analysis methods for high-throughput and high-content screening
Promotor: Prof.dr. B. van de Water
-
Ruthenium-peptide conjugates for targeted phototherapy
As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.
-
Unravelling cell fate decisions through single cell methods and mathematical models
Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.
-
Agenda dynamics in the European Union : the interaction between the European Council and the European Commission in the policy domain of organized
The European Council and the European Commission have a similar role in agenda setting. Both place issues on the EU agenda. However, these institutions have distinct designs. They have different political attributes (the European Council has considerably more political authority) and information-processing…
-
Political Muslims: Understanding Youth Resistance in a Global Context
An interdisciplinary collection of the best international scholarship on Muslim youth.
-
Making migration and migration policy decisions amidst societal transformations (PACES)
Wat is het effect van maatschappelijke veranderingen, persoonlijke levensomstandigheden en migratiebeleid op iemands besluit te migreren?
-
Flexing the Slot Regime
Op 16 december 2021 verdedigde Lisanne van Houten het proefschrift 'Flexing the Slot Regime'. Het promotieonderzoek is begeleid door prof.dr. P. Mendes de Leon en prof. L. Pierallini (Luiss University Of Rome).
-
Why is there no Northeast Asian security architecture?
Waarom is er geen Noordoost Aziatische veiligheidsstructuur? In dit artikel, gepubliceerd in The Pacific Review, bespreken auteurs Wang (Peking University) en Stevens (Leiden University) de vier obstakels voor coöperatie in Oost Azië.
-
The noisy underwater world: the effect of sound on behaviour of captive zebrafish
Promotor: Carel J. ten Cate, Co-Promotor: Hans W. Slabbekoorn
- Leiden Leadership Centre
-
Jimpitan in Wonosobo, Central Java: an indigenous institution in the context of sustainable socio-economic development in Indonesia
In times of hardships or crisis, local people know how to deal with it using their resourcefulness. Although efforts are sometimes made by the government to help them, they are fully aware that community support is at least equally important.
-
Emergence of rebellious digital press in Chile: Divergence, engagement and impact. Journal of Communication
A new publication on changes in the relationship between news and their public in Chile
-
Student Assistent
Leiden Learning & Innovation Centre
-
Monitoring and detection of nanomaterials in biological media.
How do nanoparticles bioaccumulate and biodistribute in organisms?
-
spFRET studies of nucleosome dynamics modulated by histone modifications, histone variants and neighboring nucleosomes
Promotor: Prof.dr. T. Schmidt, Co-Promotor: S.J.T. van Noort
-
Wat deelnemers aangeven
We vragen na elk seminar om feedback om van jouw ervaring te leren en onze programma's te verbeteren. Hier enkele citaten van eerdere deelnemers:
-
Empirical signatures of universality, hierarchy and clustering in culture
In this thesis,
-
Towards an effective biodiversity conservation and governance in the Pontocaspian region
Freshwater and brackish water ecosystems are arguably the most vulnerable ecosystems on earth, due to concentrated human developments in and around them. The Pontocaspian (PC) region located at the border of Europe and Asia contains a variety of brackish water ecosystems and unique inhabitants, known…
-
Postdoctoral Researcher (0.8 fte for 3 years) in the ERC Starting Grant project 'Pages of Prayer
Geesteswetenschappen, Centre for the Arts in Society
-
4 PhD Positions (0.9-1.0 FTE)
Geesteswetenschappen, Instituut voor Geschiedenis
-
Call for Papers: Behavioural Approaches in International Law
A series of workshops at Leiden University and the University of Hamburg will act as a forum in which international legal scholars whose research adopts a behavioural approach can present their works-in-progress and gain feedback from a broad range of peers, including scholars in economics and cognitive…
-
Leids Universitair Medisch Centrum
Het LUMC staat voor de verbetering van de gezondheidszorg en de gezondheid van mensen. Deze missie brengen de medewerkers van het LUMC dagelijks in de praktijk met toonaangevend onderzoek, vernieuwend onderwijs en optimale, innovatieve zorg.
-
Leidse kak helpt patiënten af van resistente darmbacteriën
Het inbrengen van poep van gezonde donoren in de darmen van chronisch zieke mensen heeft een gunstige werking op de darmbacteriën van de ontvangers. Ook op langere termijn. Dat blijkt uit onderzoek van het Leids Universitair Medisch Centrum (LUMC) en de Nederlandse Donor Feces Bank (NDFB).
-
Klimaatverandering stelt Afrikaanse grazers voor moeilijke keuze
Leeuwen beperken hun prooidieren, zoals zebra’s en gnoes, in hun mogelijkheden zich aan te passen aan een opwarmende aarde. Dat ontdekte Leidse onderzoeker Michiel Veldhuis van het Centrum voor Milieuwetenschappen in Leiden samen met internationale collega’s. Het onderzoek is op 1 juni in Nature Ecology…
-
Lecturer (replacement position) in Classical Hebrew and Aramaic
Geesteswetenschappen, Institute for Area Studies
-
PhD candidate in synthetic polymer chemistry
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
-
TT experimentele Soft Matter
Wiskunde en Natuurwetenschappen, Leids Instituut voor Onderzoek in de Natuurkunde (LION)
-
Development of an Adverse Outcome Pathway (AOP) for metallic nanoparticles
What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?
-
Develop a methodology for assessing the effective dose of nanomaterials for environmental risk assessment purposes
How to make a quantitative assessment of the relative contribution to toxicity of ions and particles? Is the toxicity of nanoparticles related to their size or shape? Which physicochemical property of nanoparticles is an appropriate dose metric of nanoparticles?
-
Onderzoek
The aim of our research program is to better understand the aetiology and course of mood, anxiety and trauma and stressor-related disorders and to test and improve treatments for these disorders.