Software and AI in Business (S&B) verbindt de domeinen wetenschap, bedrijfsleven en beleid. Wetenschappelijk onderzoek waar we ons in Leiden op richten, bijvoorbeeld op het gebied van kunstmatige intelligentie, belooft onze samenlevingen ten goede te komen. Het vertalen van wetenschap naar positieve…

Promotores: H.A. Udo De Haes, P.M. Brakefield

Consequences for sediment stability and seston trapping

The focus throughout this thesis will be on gathering fundamental studies of the detailed structure and composition of the electrode/electrolyte interface effect on the rate and mechanism of key electrocatalytic reactions.

The Economics and Governance specialisation of the Master in Public Administration teaches you to formulate problem-solving approaches to concrete policy issues found at the intersection between economics and public administration. This specialisation is a unique joint offering of the Department of…

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Promotor: Prof.dr. C.U. Keller

At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.

Because thin systems can deform along the thickness with relative ease, the interplay between surface mechanics and geometry plays a fundamental role in sculpting their three-dimensional shape.

Cardiovascular diseases are still a major concern for the global health.

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

Promotor: M.A.G.J. Orrit

Sustainable energy from wind and solar is most readily available near the sea.

What is the best way to combine the environmental and economic data and how can we create an operational system to do so, thereby supporting the delivery of data to the Data centres on Products and Resources?

Creating information portals for support of European environmental policy.

Volgens het onderzoek van de auteurs wordt verwacht dat nauwkeurigheid verbetert in minder complexe programma's, maar afneemt bij toenemende complexiteit.

Deze opleiding is gericht op de ontwikkeling van computermodellen die de werking van medicijnen voorspellen, het individualiseren van bestaande behandeltherapieën en het ontwikkelen van innovatieve, analytische tools voor het personaliseren van de gezondheidszorg.

In deze opleiding ontwikkel je je onderzoek skills en verbreed je je kennis over de meest moderne en geavanceerde technieken die je nodig hebt als onderzoeker op het gebied van target finding en het ontwerp en de synthese van nieuwe geneesmiddelen.

Op 19 mei 2020 verdedigde Xuechan Ma haar proefschrift 'Moving towards Coexistence and Cooperation: The Spratly Islands and International Law'. Het promotieonderzoek is begeleid door promotor prof.dr. N.J. Schrijver.

The thesis describes experimental steps towards reduction of friction on the macroscopic scale by scenarios of thermo- and superlubricity well-known on the nanoscale.

Ferritin is a spherical metalloprotein, capable of storing and releasing iron in a controllable way. It is composed of a protein shell of about 12 nm and within its cavity, iron is stored in a mineral form.

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Promotor: E. Gittenberger, Co-promotores: B.W. Hoeksema; L.P. van Ofwegen

In this thesis we use Josephson and noise scanning tunneling microscopy for the study of conventional, unconventional (iron-based) and disordered superconductors. On the one hand, Josephson scanning tunneling microscopy allows us to directly visualize the superfluid density with high spatial resolut…

Natural resources often stretch across borders that separate modern nation states. This can create conflict and limit opportunities for regulated consumption of their goods and services, but also provide opportunities for joint multinational efforts that exceed single country capabilities.

Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

OB associations are loose groups of young, massive stars. They constitute the last stage of the massive starformation process, and the context in which new stars are formed.

Huub de Groot

Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?

Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL), Leiden Academic Centre for Drug Research (LACDR)

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Cardiovascular disease is the leading cause of death worldwide.

Het onderzoekscluster ‘Conflict, Conflict Resolution and Crisis Management’ maakt deel uit van het onderzoeksprogramma ‘Institutions, Decisions and Collective Behaviour’. De betrokken onderzoekers bestuderen hoe politieke conflicten ontstaan en welke typen crises we kunnen onderscheiden. Hoe hanteren…

Latent variable modeling of students' solution strategies and performance

Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.

Promotor: Prof.dr. E. F. van Dishoeck

This book explores the spiritual potential of faith, mysticism and transcendence in answer to the dangers of a mythologised state and the sacro-sanctification of (liberal) democracy and its rule of law.

The interest of this thesis lies in spin transport in normal metals and superconducting half-metallic junctions.

Het Institute of Security and Global Affairs (ISGA) opereert binnen de internationaal georiënteerde wetenschappelijke richting security studies en houdt zich bezig met multidisciplinair onderzoek en onderwijs.

Het doel van deze faciliteit is om het biomedisch onderzoek te versnellen door toegang te bieden tot geavanceerde licht- en elektronenmicroscopie en door het delen van expertise over monstervoorbereiding, beeldvormingsmodaliteiten, gegevensopslag en beeldanalyse.

Diverse types of exoplanets such as gas giants on close-in orbits (hot Jupiters) and young massive giants on wide orbits (super Jupiters), with no analogs in the Solar System, pose challenges but also opportunities to our understanding of planet formation and evolution.

The applications of studying the early development of insects range from agriculture to material science.

Promotor: C.J. ten Cate

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.

In-use stocks of products can be considered as intermediaries between human needs and the physical world.

Deze masterspecialisatie leert je veelvoorkomende leerproblemen herkennen en behandelen.