79 zoekresultaten voor “regenerative tissue” in de Publieke website
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Transfusion Medicine and Cellular and Tissue Therapies (MSc)
This joint Master with the Autonomous University of Barcelona will the equip you with the necessary competences to play a key role in the emerging field of transfusion medicine. The programme includes both transfusion of blood components and hematopoietic transplants, cellular and tissue therapy, and…
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Transfusion Medicine and Cellular and Tissue Therapies (MSc)
Dit masterprogramma voorziet je van de nodige competenties om een sleutelrol te spelen in het opkomende gebied van transfusiegeneeskunde. Het huidige concept omvat zowel transfusie van bloedbestanddelen als hematopoëtische transplantaties, cel- en weefseltherapie en immunotherapie. Gebieden die geïntegreerd…
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Integrating cellular and tissue dynamics with cell fate decisions through computational modeling
There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…
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This is life: some thoughts on self-organized structure formation in active liquids and biological systems
It has been a long-standing mystery how complex biological structures emerge from such seemingly uncoordinated building blocks as cells and tissues, in the presence of only minimal environmental guidance.
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Public Regenerative Medicine Day
Publieksdag | Leiden2022
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Paulus Quax
Faculteit Geneeskunde
p.h.a.quax@lumc.nl | +31 71 526 1584
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Dorien Peters
Faculteit Geneeskunde
d.j.m.peters@lumc.nl | +31 71 526 9490
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Personalised medicine for multiple outcomes: methods and application
The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.
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Multilayer porous scaffold for cartilage tissue engineering
Promotie
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Novel regenerative therapies for the adaptive immune system
Promotie
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Visual analytics for spatially-resolved omics data at single cell resolution: Methods and Applications
The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…
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Targeting adipose tissue to improve cardiometabolic health
Promotie
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Prediction of spatial-temporal brain drug distribution with a novel mathematical model
A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.
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Forces and symmetries in cells and tissues
The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.
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Unravelling cell fate decisions through single cell methods and mathematical models
Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.
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Online Experience Master Transfusion Medicine and Cellular and Tissue Therapies
Studievoorlichting
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Non-invasive assessment of human brown adipose tissue
Promotie
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The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
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Onderwijs
In het Leids Universitair Medisch Centrum (LUMC) word je klaargestoomd voor de wereld van morgen. We brengen op een unieke manier onderzoek en patiëntenzorg samen in ons onderwijs.
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Antonius Johannes Rabelink
Faculteit Geneeskunde
a.j.rabelink@lumc.nl | +31 71 526 2148
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Development of an in vitro vascular network using zebrafish embryonic cells
One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.
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Investigations on the role of impaired lysosomes of macrophages in disease
The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.
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Activity-based proteomics of the endocannabinoid system
This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.
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Online Q&A Master Transfusion Medicine and Cellular and Tissue Therapies
Studievoorlichting
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Integrating cellular and tissue dynamics with cell fate decisions through computational modeling
Promotie
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Swimming Bass under Pounding Bass: fish response to sound exposure
Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn
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Phenotypic screening with 3D cell-based assays
Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.
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Dyslipidemia, metabolism and autophagy: antigen-independent modulation of T cells in atherosclerosis
Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.
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Computational modeling of angiogenesis : from matrix invasion to lumen formation
Promotor: Roeland M.H. Merks
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Applications for activity-based probes in biomedical research on glycosidases
Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.
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High throughput microscopy of mechanism-based reporters in druginduced liver injury
Promotor: B. van de Water
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Reverse engineering of drug induced QT(c) interval prolongation: Towards a systems pharmacology approach
Promotor: M. Danhof Co-promotor: O.E. Della Pasqua
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Evaluation of the zebrafish embryo as an alternative model for hepatotoxicity testing
Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis
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Chitin in the fungal cell wall: towards valorization of spent biomass of Aspergillus niger
Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.
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Vasculaire en Regeneratieve Geneeskunde
Behandelmethoden voor chronische ziekten zijn beperkt. Artsen en onderzoekers van het Leids Universitair Medisch Centrum (LUMC) en de Universiteit Leiden werken aan nieuwe therapieën als alternatief voor orgaantransplantatie. Doel is om organen te herstellen in hun oorspronkelijke functie en op die…
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Online Master’s Experience: Master Transfusion Medicine and Cellular and Tissue Therapies
Studievoorlichting
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Biomaterials for delivering biotherapeutic molecules in bone and cartilage tissue
Promotie
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Impact of plant hormones on growth and development of actinobacteria
Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.
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Shape Analysis for Phenotype Characterisation from High-throughput Imaging
We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.
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Photo-activation of ruthenium-decorated upconverting nanoparticles
Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).
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Concepts and applications for evidence-based dosing in morbidly obese patients before and after weight loss surgery
Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst
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Microfluidic 3D cell culture for high throughput screening
There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.
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Development of a Kidney-on-a-Chip Model for Compound Screening and Transport Studies
Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…
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Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
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Temperature effects on genetic and physiological regulation of adaptive plasticity
Promotor: P.M. Brakefield
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Leids Universitair Medisch Centrum
Het LUMC staat voor de verbetering van de gezondheidszorg en de gezondheid van mensen. Deze missie brengen de medewerkers van het LUMC dagelijks in de praktijk met toonaangevend onderzoek, vernieuwend onderwijs en optimale, innovatieve zorg.
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Development of an Adverse Outcome Pathway (AOP) for metallic nanoparticles
What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?
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Na je studie
Na de bachelor kun je doorstromen in onze master Geneeskunde. Rond je die ook succesvol af, dan ben je basisarts. Daarna kun je je specialiseren, promotieonderzoek doen, of werken als basisarts.
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Erik Danen wil tumoren vangen in hun eigen web
Erik Danen speurt met succes naar wegen om tumoren die slecht op medicijnen reageren de pas af te snijden. De hoogleraar Cancer Drug Target Discovery kijkt hiervoor naar de interactie tussen tumorcellen en hun omgeving. Oratie vrijdag 10 mei.
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Frank Baas
Faculteit Geneeskunde
f.baas@lumc.nl |