Promotie

Promotie

Een cognitieve revalidatie therapie voor mensen met navigatieproblemen als gevolg van NAH

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.

Promotor: Prof.dr. M. Danhof

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Wilt u meer weten over de Universiteit Leiden? Lees onze publicaties online of vraag ze aan.

De Universiteit Leiden is ruim twintig jaar gevestigd in Den Haag en ziet de stad als haar tweede moederstad.

Discover the Summer School Program Population Health Management by LUMC and learn about strategies to deal with current issues and developments in healthcare.

Promotor: G.J.B. van Ommen

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

Het LUGO-team maakt deel uit van het Bestuursbureau van de universiteit, waar het onder de directie Strategie en Academische Zaken valt. Binnen Strategie en Academische Zaken is LUGO onderdeel van team Duurzaamheid, dat, naast LUGO, ook twee full-time werknemers heeft. Het Bestuursbureau ondersteunt…

NNMT wordt beschouwd als een nieuw potentieel farmacologisch doelwit in de behandeling van een verscheidenheid van kankers, stofwisselingsziekten en andere pathologieën. Het toenemend aantal publicaties waarin de rol van NNMT bij ziekten wordt opgehelderd, heeft op zijn beurt de ontwikkeling van krachtige…

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

Which traits and/or trade-offs determine benefits of being deciduous or evergreen?

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

Learning from small data sets in machine learning is a crucial challenge, especially when dealing with data imbalances and anomaly detection. This thesis delves into the challenges and methodologies of learning from small datasets in machine learning, with a particular focus on addressing data imbalances…

Het Bestuursbureau ondersteunt het College van Bestuur en draagt zorg voor de beleids- en besluitvorming.

De Universiteit Leiden werkt aan een groene, circulaire campus, met een forse energiereductie in 2050 als doel, zoals uitgewerkt in de in 2022 verschenen Routekaart energietransitie gebouwen.

Deze opleiding wordt aangeboden door het Leiden Institute of Advanced Computer Science. In deze opleiding analyseer je hoe ICT, innovatie mogelijk maakt in sectoren van het bedrijfsleven als marketing, financiën en strategie. Internationale uitwisseling en in-company scriptieprojecten bij vooraanstaande…

With the rise of multi-drug resistant bacterial pathogens, the possibility of a post-antibiotic world is quickly becoming reality.

Loopbaan en solliciteren

This thesis mainly focuses on multimodal understanding and Visual Question Answering (VQA) via deep learning methods. For technical contributions, this thesis first focuses on improving multimodal fusion schemes via multi-stage vision-language interactions.

One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.

Current therapies for patients with atherosclerosis are targeted primarily on reducing blood cholesterol, but this fails to prevent a large number of cardiovascular events.95 In order to identify new therapeutic strategies for treating atherosclerosis, it is important to study the interactions between…

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

In Europe a number of production and communication strategies have long tried to establish local products as resources for local development. At the foot of the Alps, this scenario appears in all its contradictions, especially in relation to cheese production. The Heritage Arena focuses on the saga…

The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway.

Promotores:Th.J.C. van Berkel, M. van Eck

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

De volgende medewerkers maken deel uit van de Academia in Motion Regiegroep.

De Una Europa Clusters brengen vooraanstaande deskundigen en ervaren personeelsleden van de talrijke academische en professionele diensten van de Una Europa -partners samen.

The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…

Lezing

How can mega sand nourishments, such as the Sand Motor, be designed and managed for optimal ecosystem services provision ?

How can we, together international experts, define future needs of R+D contributions for innovations in the field of risk-based management of chemicals and products in a global perspective using alternative testing strategies to minimize animal tests?

Some examples of research questions include: What framework of circular strategies should local practitioners use? How should practitioners organize their monitoring of the circular economy activities in the region of interest? What are the main products that have the most circular potential in the…

De onderzoeksgroep Corporate Governance en Strategie onderzoekt hoe, met wie en voor wie een onderneming waarde creëert/vastlegt, met als doel de praktijk en beleidsmakers te informeren over kwesties rondom bestuur. De onderzoeksgroep focust zich op het duale karakter van de onderneming. Namelijk als…

Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

Glucocorticoids are potent anti-inflammatory drugs widely used clinically to treat various inflammatory and immune conditions. However, two main clinical problems limit their use. GCs trigger severe side effects and they induce acquired glucocorticoid resistance, especially during chronic systemic treatment…

Heart failure is a major health care problem with high mortality.

Together@FGGA - Samen werken aan een veilige, inclusieve en evenwichtige werkomgeving

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

Bacteria have the ability to alter their morphology in order to adapt to changing environments.

Promotor: I. A. G. Snellen, Co-promotor: M. A. Kenworthy

This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.