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Postdoc position in cellular longevity and stress response modelled by stem cells from a variety of species.

Vacature nummer
Wetenschappelijke functies
Intern , Extern
Publicatie datum
23 augustus 2022
30 september 2022 Vacature gesloten

The Faculty of Science and the Leiden Academic Centre for Drug Research are looking for a:

Postdoc position in cellular longevity and stress response modelled by stem cells from a variety of species.

Vacancy number: 22-529

Key responsibilities
The fact that neurons and other types of cells in the human body are rarely replaced raises the question of the mechanisms that enable cells to function properly for decades and possibly 100 years or more. The postdoc will be part of a team that investigates a new research direction that connects the efficiency of stress response to cellular and animal lifespan, and analyze candidate genetic mechanisms. The postdoc will participate in the establishment and utilization of induced pluripotent stem cells from understudied mammalian species including great apes and rhino, i.e. an iPSC zoo collection.

The postdoc will produce transgenic iPSCs and mice to investigate the role of mammalian long noncoding RNA genes that are involved in stress-induced complexes that protect cells from protein and DNA damage. The project will deliver answers on the ability of cells to withstand prolonged stress in relation to animal lifespan. The multispecies stem cell approach will open new avenues for evolution and genetics.

The postdoc will use a variety of technologies including cellular reprogramming, next generation sequencing, high throughput microscopy, CRISPR-CAS gene editing, and work in close collaboration with bioinformaticians.

The candidate will be embedded in the research group of Prof.dr. M. Drukker, focused on stem cells technologies in order to create novel models for human disease and drug development.

Selection criteria

  • A PhD degree in Biology, Genetics, Biomedical sciences or a related field;
  • Expertise in stem cell culture, molecular and cell biology, biochemistry, microscopy, genetic models
  • Skills in quantitative image analysis or bioinformatics;
  • Strong communication skills in the group and with collaborators;
  • Proficiency in English;
  • Excellent organisational and planning skills (efficient time management).

Our organizations
Working at the Faculty of Science means being part of an exciting, dynamic scientific environment which sets high standards for its students and staff. The research carried out at the Faculty of Science is diverse, ranging from computer science, mathematics, astronomy, physics, chemistry and bio-pharmaceutical sciences to biology and environmental sciences.

The faculty has grown strongly in recent years and now has more than 2,300 staff and over 5,000 students. We are located at the heart of Leiden’s Bio Science Park, one of Europe’s biggest science parks, where university and business life come together. For more information, see https://www.universiteitleiden.nl/en/science.

Terms and conditions
We offer a full-time, one year term position, with the possibility of renewal for an additional 2 years based on performance. Salary range from € 2.960,- to € 4,670.- (fulltime, scale 10, in accordance with the Collective Labour Agreement for Dutch Universities).

Leiden University offers an attractive benefits package with additional holiday (8%) and end-of-year bonuses (8.3 %), training and career development and sabbatical leave. Our individual choices model gives you some freedom to assemble your own set of terms and conditions. Candidates from outside the Netherlands may be eligible for a substantial tax break. For more information (https://www.universiteitleiden.nl/en/working-at/job-application-procedure-and-employment-conditionshttps://www.universiteitleiden.nl/en/working-at/job-application-procedure-and-employment-conditions), see the website.

Enquiries can be made to Micha Drukker (m.drukker@lacdr.leidenuniv.nl) and Ksenia Arkhipova (k.arkhipova@lacdr.leidenuniv.nl). If you have any questions about the procedure, please contact the secretariat of the Division of Drug Discovery & Safety, Marjolijn Lugthart (m.j.l.lugthart@lacdr.leidenuniv.nl).

To apply for this vacancy, please send an email to Marjolijn Lugthart (m.j.l.lugthart@lacdr.leidenuniv.nl).
Please ensure that you upload the following additional document quoting the vacancy number:

  • Cover letter
  • Curriculum vitae
  • A synopsis of PhD thesis.
  • Reference letters sent directly by referrers

Only applications received before September 30, 2022 can be considered.

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