926 zoekresultaten voor “health and disease” in de Publieke website
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Quantitative pharmacology of antimicrobials
Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.
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Data-Driven Machine Learning and Optimization Pipelines for Real- World Applications
Machine Learning is becoming a more and more substantial technology for industry.
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Multimodality imaging in patients with valvular heart disease and systemic diseases
Promotie
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Chemical tools to study the cannabinoid receptor type 2
The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…
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Identification of Therapeutic Targets and Antisense Oligonucleotide Mediated Exon Skipping Based Therapies in Arthritis
Promotor: G.J.B. van Ommen
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Microvasculature in Microfluidics: matching complexity with compatibility
In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…
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Elucidating the pathogenesis underlying bicuspid aortic valve disease using new disease models
Promotie
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CD8+ T-cells in atherosclerosis: mechanistic studies revealing a protective role in the plaque microenvironment
Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.
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Cholesterol metabolism in mouse models of atherosclerosis and adrenal steroidogenesis
Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.
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Generalized Strictly Periodic Scheduling Analysis, Resource Optimization, and Implementation of Adaptive Streaming Applications
This thesis focuses on addressing four research problems in designing embedded streaming systems.
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Digging for data: the rise and fall of a Miocene mammal biodiversity hotspot in the Vallès-Penedès (Catalonia, Spain)
The Vallesian, 11.1-9 Ma, was a special time in the Vallès-Penedes basin near Barcelona, where a biodiversity hotspot existed. Europe had a subtropical climate, with rhinos, forest giraffes, lions, hyenas, flying squirrels and primates.
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Freezing conditions in warm disks: snowlines and their effect on the chemical structure of planet-forming disks
This thesis focusses on the temperature structure in protoplanetary disks. The relation between structures seen in the dust and gas-phase molecules is investigated.
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Maatwerk & de Menselijke Maat
Van publieke organisaties wordt in toenemende mate verwacht dat zij maatwerk leveren en de menselijke maat meewegen in besluiten. De toeslagenaffaire, decentralisaties in het sociale domein en problemen bij uitvoeringsorganisaties hebben deze thema’s hoog op de politieke en bestuurlijke agenda gezet.…
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Invariant manifolds and applications for functional differential equations of mixed type
Promotor: S.M. Verduyn Lunel
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Human skin equivalents for atopic dermatitis: investigating the role of filaggrin in the skin barrier
Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri
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Sensing Transport
Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.
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Frits Rosendaal
Faculteit Geneeskunde
f.r.rosendaal@lumc.nl | +31 71 526 4037
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Maximal Systolic Acceleration in atherosclerotic vascular disease
Promotie
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Predicting Outcomes in Patients with Kidney Disease
Promotie
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Adult weight change and cardiometabolic disease
Promotie
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Conceptualisation of disease resolution in rheumathoid arthritis
Promotie
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Cardiovascular disease burden in thoracic aortopathy
Promotie
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Inflammatory Bowel Disease in Older Patients
Promotie
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Haico van Attikum
Faculteit Geneeskunde
h.van.attikum@lumc.nl | +31 71 526 9624
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Céline Zaepffel
Faculteit der Geesteswetenschappen
c.v.zaepffel@hum.leidenuniv.nl | +31 71 527 2050
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Paulus Quax
Faculteit Geneeskunde
p.h.a.quax@lumc.nl | +31 71 526 1584
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Dorien Peters
Faculteit Geneeskunde
d.j.m.peters@lumc.nl | +31 71 526 9490
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Mila van Nieuwenhuizen
Faculteit der Geesteswetenschappen
m.van.nieuwenhuizen@hum.leidenuniv.nl | +31 71 527 2125
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Joeri Lammerts
Faculteit Governance and Global Affairs
j.lammerts@fgga.leidenuniv.nl | +31 70 800 9506
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Cornelis Hokke
Faculteit Geneeskunde
c.h.hokke@lumc.nl | +31 71 526 5065
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Wiskundig model helpt ontstaan van wervels en ribben te verklaren
Leidse wiskundig biologen hebben een model ontwikkeld dat helpt verklaren hoe onder meer de ruggengraat en de wervels ontstaan in de embryonale ontwikkeling. Hetzelfde proces, maar dan andersom, speelt een sleutelrol bij de uitzaaiing van kanker. Publicatie in iScience.
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the C&D waste management systems in the Netherlands, Belgium, Spain and Finland
What are the flows of C&DW (e.g. bricks, concrete, gypsum and wood) in the case study countries ? How to define the specification for each material to be quantified? What indicators should be used to identify the pattern of each C&DW management system? How to interpret the MFA results in relation…
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Joanne Mouthaan
Faculteit der Sociale Wetenschappen
j.mouthaan@fsw.leidenuniv.nl | +31 71 527 6781
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Profielwerkstuk
Antibiotica, bacteriën en resistentie zijn zeer geschikte onderwerpen voor een profielwerkstuk. Hier vind je alvast een aantal handige links.
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Tijmen Baarda
Universitaire Bibliotheken Leiden
t.c.baarda@library.leidenuniv.nl | +31 71 527 2727
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Meeloopdag - Health & Medical Psychology
Studievoorlichting
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Meeloopdag - Health & Medical Psychology
Studievoorlichting
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webinar Population Health Management
Studievoorlichting
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Proefcollege Population Health Management
Studievoorlichting
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Jordy van der Beek
Wiskunde en Natuurwetenschappen
j.g.van.der.beek@cml.leidenuniv.nl | +31 71 527 2727
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Maria Yazdanbakhsh
Faculteit Geneeskunde
m.yazdanbakhsh@lumc.nl | +31 71 526 5067
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Laat je verrassen tijdens de Healthy University workshops
Van oefeningen om gezonder te werken tot praktische tips over lekker slapen. Studenten en medewerkers die deelnemen aan de Healthy University Workshops op 18 of 19 oktober krijgen persoonlijke tips die goed bij hun situatie passen.
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Tackling chronic respiratory disease in low-resource settings
Promotie
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PhD candidate - biodiversity & society: the Dutch home as a multispecies space
Sociale Wetenschappen
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for spatially-resolved omics data at single cell resolution: Methods and Applications
The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…
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Fluorescence Polarization Activity-Based Protein Profiling on Retaining Glycosidases
Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.
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B cell modulation in atherosclerosis
Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.
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Exploring chemical space in covalent and competitive glycosidase inhibitor design
Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency
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Involvement of host and bacterial factors in Agrobacterium-mediated transformation
Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.
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Chemical genetic approaches for target validation
Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.