Stemwijzers—applicaties die kiezers helpen te bepalen welke partij of kandidaat het beste past bij hun politieke voorkeur—spelen een steeds belangrijker rol in verkiezingen. De politicologen Martin Rosema (Universeit Twente) en Tom Louwerse (Universiteit Leiden) onderzoeken of het ontwerp van deze publicaties…

Leiden University offers a unique range of summer courses where you can broaden or deepen your knowledge or share your expertise with fellow students. The choice of academic courses is very diverse, ranging from Law, Big Data, Languages and Linguistics to Maths and Natural Sciences, Biology, Biomedical…

The Study Information Committee works to create a positive and accurate picture of the bachelor and master programs offered by the Institute of Biology Leiden (IBL). The committee consists of IBL staff members and study ambassadors. We reach out to future and current students, high school biology teachers,…

D1.3 describes a set of five case studies relevant in the context of the EuDEco project. Case studies are considered relevant if they are initiatives focusing on the promotion of big data and data reuse or pilots facilitating data reuse in one form or the other. The case studies were expected to allow…

Endothelial dysfunction and microvascular diseases are key drivers of cardiovascular disease, the world's leading cause of death.

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The cellular metabolism of immune cells constitutes an important part of their proper function and activation. Using T cells as an example, this phenomenon is highlighted by the metabolic reprogramming that occurs in these cells upon activation.

The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

In this thesis, the research focuses on the properties of dark matter and dark matter haloes and how they connect with the galaxies we can observe in the Universe.

Promotores: F.H.J. Redig, W.T.F. den Hollander

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

This thesis advances our understanding of lipid uptake, a vital first step in lipid metabolism, by developing innovative click chemistry-based tools to study how immune cells internalize lipids.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

This thesis describes a study from both a theoreticaL and an experimental point of view.

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

In this thesis we have discussed several parameters that affect the electrochemical conversion of enviromentaly harmful molecules such as nitrates and carbon dioxide to more valuable and less deleterious compounds, in order to cast light onto the mechanism of the reaction to achieve an efficient and…

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).

This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.

Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…

Promotor: Prof.dr. H.V.J. Linnartz

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Promotor: B.van de Water, Co-promotor: L.S.Price

Promotor: Prof.dr. G.P. van Wezel

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

Promotie

Lezing, Com(parative) Syn(tax) Series

Chinese materia medica (CMM), comprising a diverse array of natural substances from plants, animals, and minerals, has been integral to Traditional Chinese Medicine (TCM) throughout history. This study investigates the dynamic evolution of CMM, noting shifts in species for improved therapeutic effects…

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

Een goede taalontwikkeling is van belang voor de cognitieve en sociale ontwikkeling, om te kunnen communiceren en om te kunnen leren. Als de taalontwikkeling niet verloopt zoals verwacht, kan dit allerlei consequenties hebben. Kinderen met een extra X of Y chromosoom hebben een verhoogd risico op problemen…

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

Op 19 september 2019 verdedigde Lynette Janssen zijn proefschrift 'EU Bank Resolution Framework: A comparative study on the relation with national private law'. Het promotieonderzoek is begeleid door promotoren prof.mr. W.A.K. Rank en prof.mr. M. Haentjens.

This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

Centraal in dit proefschrift staan de perspectieven van docenten met betrekking tot zelfstandig leren.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

n this PhD thesis, the recombination of different atomic lattices in stacked 2D materials such as twisted bilayer graphene is studied. Using the different possibilities of Low-Energy Electron Microscopy (LEEM), the domain forming between the two atomic layers with small differences is studied.

Including modelling as part of software development appears to have various benefits.

Like a mixture of oil and water, lipid membranes separate into two liquid phases.

Solar energy harnessed by plants and algae has great potential to be converted into biofuels for future generations.

This thesis investigated miniaturized mass spectrometry (MS)-based analytical methods to address challenges in analyzing biomass-restricted biological samples.