282 zoekresultaten voor “biomoleculaire aggregates and condensates” in de Publieke website
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Analysis of sub-visible particles in complex injectable formulations
Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik
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Soil organic amendments for climate-smart agriculture
Organic amendments applied to agricultural fields can partially offset our carbon emissions to the atmosphere and improve the resilience of agriculture to the effects of climate change. Driving these benefits, however, are complex and poorly understood interactions between organic amendment properties,…
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Natural and non-natural factors influencing Alzheimer´s Aβ
Promotor: Prof.dr. J.P. Abrahams
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Jakub Senesi -
Exploring and exploiting the mechanism of mycelial pellet formation by Streptomyces
Promotor: G.P. van Wezel
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Pharmaceutical Aspects of Subvisible Particles in Protein Formulations
Promotor: W. Jiskoot, Co-promotor: A. Hawe
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Novel analytical approaches to characterize particles in biopharmaceuticals
Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).
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Spin-triplet supercurrents of odd and even parity in nanostructured devices
Triplet superconductivity refers to a condensate of equal-spin Cooper pairs (pairs of electrons with equal spin).
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Josephson and noise scanning tunneling microscopy on conventional, unconventional and disordered superconductors
In this thesis we use Josephson and noise scanning tunneling microscopy for the study of conventional, unconventional (iron-based) and disordered superconductors. On the one hand, Josephson scanning tunneling microscopy allows us to directly visualize the superfluid density with high spatial resolut…
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Squaramide-based supramolecular polymers : from self-assembly to in vivo application
The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water.
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Putting a spin on it: amyloid aggregation from oligomers to fibrils
This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.
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Musems, Collections and Society | Yearbook 2020
In this Yearbook you will find some fascinating examples of what was done in 2021, not only by ourselves, but also by our international colleagues.
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Musems, Collections and Society | Yearbook 2021
In this Yearbook you will find some fascinating examples of what was done in 2021, not only by ourselves, but also by our international colleagues.
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Topological decoding of biomolecular fold complexity
Biological polymers, including proteins and the genome, undergo folding processes crucial for their proper functioning. Even slight changes in the folding structure of these biopolymers can have significant implications, leading to the development of various pathological conditions, such as neurodegenerative…
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Liposomes as delivery system for allergen-specific immunotherapy
In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.
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Citizenship, Migration and Global Transformations
Europese burgers worden geconfronteerd met uitdagingen op het gebied van globalisering, migratie, technologische ontwikkelingen en klimaatverandering. Deze uitdagingen vergen het uiterste van onderlinge internationale en intergenerationele solidariteit, wat rechtstreeks betrekking heeft op de grondslagen…
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A computational study of structural and excitonic properties of chlorosomes
The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…
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Quantitative Super-Resolution Microscopy
Promotor: T. Schmidt
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In vitro investigation of the photoprotection mechanism of Light Harvesting Complex II
Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.
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industrial carbon emissions: Historical drivers at the regional and sectoral levels and projections in light of policy
This thesis studied in depth the energy use and CO2 emissions of the industrial sector in China.
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Methods and Tools for Mining Multivariate Time Series
Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.
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A composite indicator for evaluating safety and sustainability by design and circularity in emerging technologies
De eerste index om de veiligheid, duurzaamheid en circulariteit van producten te meten, waarmee ze het EU-kader (SSbD) operationaliseren.
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The Universality of Literature: Giacomo Prampolini, Translator and Mediator
Congres/symposium
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Ice and Gas in Protostellar Clouds and Planet-forming Disks
This thesis takes steps toward understanding the interaction between gas-phase and solid-state molecules in star- and planet-forming regions.
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Measuring wellbeing in climate and socioeconomic scenarios
Over the past two centuries, socioeconomic development has improved material living standards but has also intensified environmental pressures, including climate change and biodiversity loss.
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Bioengineering and biophysics of viral hemorrhagic fever
Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…
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Synthesis and Characterization of Boron, Nitrogen, and Carbon-Based Two-Dimensional Materials
This thesis comprises the development of reproducible synthesis procedures for two-dimensional materials (composed of boron, nitrogen and carbon) on different metallic surfaces.
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Orion's Dragon and Other Stories
Stellar feedback is a crucial ingredient in the evolution of galaxies.
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A systematic literature review of security and privacy by design principles, norms, and strategies for digital technologies
Dit artikel biedt een systematisch literatuuronderzoek van de belangrijkste principes, normen en strategieën van Security by Design en Privacy by Design.
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Night Spaces: Migration, Culture and Integration in Europe (NITE)
Hoe worden nachtruimtes verbeeld, geproduceerd, ervaren en verteld door migrantengemeenschappen in Europa? Dit onderzoeksproject onderzoekt deze vraag in acht Europese steden: Aarhus, Amsterdam, Berlijn, Cork, Galway, Lissabon, Londen en Rotterdam.
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Environmental and health impact of informal e-waste recycling
The majority (80%) of e-waste generated globally are recycled informally in developing countries.
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Chinese assertiveness and the rise of Xi Jinping: ideational mobilization, elite contestation, and the struggle over regional order
In 2009-2010 ontstond in het westerse discours het idee van een meer ‘assertief’ China, een opvatting die China krachtig van de hand wijst. Niettemin is, vooral sinds Xi Jinping in 2012 aan de macht kwam, duidelijk dat China zijn lang gehanteerde buitenlandse beleidsdoctrine van ‘een lage profilering…
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Surveying young stars with Gaia: Orion and the Solar neighbourhood
OB associations are loose groups of young, massive stars. They constitute the last stage of the massive starformation process, and the context in which new stars are formed.
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not a man’s problem? Comparing post #MeToo policy and awareness training in the Dutch and French cultural sectors
Why do sexual violence policies still fail to systematically address men and masculinities, when the need for cultural change among men has been central in public debates since #MeToo?
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Spectral localisers and aperiodic topological phases in noncommutative geometry
The dissertation offers new tools and insights to computation and modelling of topological phases, with an emphasis on the aperiodic setting.
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Towards circular and energy-efficient management of building stock
Material circularity and energy efficiency are highly relevant and intertwined issues for the transition towards a carbon-neutral and circular built environment. In the Netherlands, the building sector has been rendered a priority towards a circular and low-carbon society.
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Between Canon and Coincidence: using data-driven approaches to understand Art Worlds (BECACO)
Indigenous Latin American artifacts have attracted the interest of Europeans since the earliest moment of contact between Europeans and the Indigenous peoples of the Americas. The ERC-funded BECACO project uses an innovative multidisciplinary framework to investigate the provenance of ethnographic and…
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Theory of mind in language, minds, and machines: a multidisciplinary approach
Humans can see the world through the eyes of other humans and imagine what they know, want, and intend. This competence is known as Theory of Mind.
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Generalized Strictly Periodic Scheduling Analysis, Resource Optimization, and Implementation of Adaptive Streaming Applications
This thesis focuses on addressing four research problems in designing embedded streaming systems.
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Robotic reconstitution of cytostatic drugs and monoclonal antibodies: transforming aseptic drug compounding in hospital pharmacies
Hospital pharmacies face significant challenges: the demand for sterile drug reconstitutions is increasing, while specialized personnel remain scarce. Automation offers a potential solution, but its practical implementation in hospitals is still unclear.
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pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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Digging for data: the rise and fall of a Miocene mammal biodiversity hotspot in the Vallès-Penedès (Catalonia, Spain)
The Vallesian, 11.1-9 Ma, was a special time in the Vallès-Penedes basin near Barcelona, where a biodiversity hotspot existed. Europe had a subtropical climate, with rhinos, forest giraffes, lions, hyenas, flying squirrels and primates.
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What’s CLIL about bilingual education? A window on Content and Language Integrated Learning pedagogies
In Nederland bieden ongeveer 130 van de 700 middelbare scholen een tweetalige stroom aan. Toch is er nog maar weinig wetenschappelijk onderzoek naar CLIL (content and language integrated learning). Met haar proefschrift wil Evelyn van Kampen (promovendus bij het ICLON) bijdragen aan een beter begrip…
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Freezing conditions in warm disks: snowlines and their effect on the chemical structure of planet-forming disks
This thesis focusses on the temperature structure in protoplanetary disks. The relation between structures seen in the dust and gas-phase molecules is investigated.
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Invariant manifolds and applications for functional differential equations of mixed type
Promotor: S.M. Verduyn Lunel
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Transdisciplinary Perspectives on Validity: Bridging the Gap Between Design and Implementation for Technology-Enhanced Learning Systems
Technologies that help to enhance our educational environments can be found everywhere.
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Beeldverwerking en bio-informatica
Aan de hand van de karakteristieke aspecten van een beeld kunnen bepaalde computers ons vertellen wat het beeld laat zien. Ze kunnen dit leren op dezelfde manier als jonge kinderen beelden kunnen leren herkennen. Het verder verbeteren van deze technieken opent de weg naar een hele reeks nieuwe toepassingen.…
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Onze mensen
Dit zijn de mensen die binnen de Universiteit Leiden actief zijn op het gebied van kunstmatige intelligentie.
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Computer vision en beeldverwerking
Aan de hand van de karakteristieke aspecten van een beeld kunnen bepaalde computers ons vertellen wat het beeld laat zien. Ze kunnen dit leren op dezelfde manier als jonge kinderen beelden kunnen leren herkennen. Het verder verbeteren van deze technieken opent de weg naar een hele reeks nieuwe toepassingen.…
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Marileen Dogterom wordt bestuurslid bij KNAW
Per 1 juni treedt Marileen Dogterom, hoogleraar biomoleculaire fysica in Leiden en Delft, toe tot het bestuur van de KNAW.