Van de patiënten met multipele sclerose (MS) krijgt 34-65% vroeg of laat te maken met cognitieve problemen.

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.

Factoren van invloed op arbeidsparticipatie onder mensen met multiple sclerose

Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Overkleeft

Hoe dragen vetten en enzymen in de hersenen bij aan multiple sclerose? In zijn promotieonderzoek combineerde Daan van der Vliet chemie en neurowetenschap om nieuwe inzichten te krijgen in het ontstaan van hersenziekten.

Galaxies form and live inside dark matter haloes. As a consequence, they are exposed to the tidal fields generated by the surrounding matter distribution: this imprints a preferential direction to the galaxy shapes, which leads to a coherent alignment on physically close galaxies, called intrinsic a…

Promotor: J.W.M. Frenken Co-Promotor: R. Felici

This thesis investigates the application of deep learning techniques in image analysis across various domains, focusing on four main themes: feature extraction, classification, segmentation, and integration, demonstrating the transformative potential of these technologies.

The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.

Promotie

Leidse chemici hebben een nieuw mechanisme ontdekt dat zou kunnen verklaren hoe Multiple Sclerose zich ontwikkelt tot een ernstigere vorm. Met hun bevindingen dragen ze bij aan het ontrafelen van het mysterieuze verloop van de ziekte. Het onderzoek is gepubliceerd in het tijdschrift Biochemistry.

The thesis describes the development, synthesis and biological evaluation of several proteasome inhibitor designs. Mainly, this work focusses on designing proteasome inhibitors that selectively inhibit the immunoproteasome, while leaving the constitutive proteasome mostly, if not completely, untouch…

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

Drug development critically depends on preclinical models that mimic human physiology, yet traditional two-dimensional cultures and animal models often lack predictive power.

Wat zijn de vaak onzichtbare cognitieve gevolgen van multiple sclerose? Die bracht Maureen van Dam tijdens haar promotieonderzoek in kaart. ‘De lichamelijke symptomen zien mensen meestal wel, maar de cognitieve symptomen verdienen minstens net zoveel aandacht.'

In de MS Cognitietour gaan Leidse psychologen en neurowetenschappers met MS-patiënten en hun naasten in gesprek over de nieuwste wetenschappelijke kennis. Dat leidt tot nieuwe inzichten: ‘Een mevrouw vertelde hoeveel stress zij had van al die zorgverleners om haar bed.’

Het Institute for Chemical Immunology (ICI), waarvan chemische biologie van de Universiteit Leiden initiatiefnemer is, heeft een subsidie van 27,6 miljoen euro toegekend gekregen. In het ICI slaan wetenschappers van Nederlandse universiteiten en instituten op de terreinen immunologie en chemie de handen…

Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken

Promotor: Prof.dr. S.F. Portegies Zwart

Onder vindt u de wetenschappelijke publicaties van het Navigatie Lab Leiden

Promotoren: R. Tijdeman, A.K. Lenstra, Co-promotor: H.J.J. te Riele

Onderzoekers van het Instituut Psychologie ontvangen een NWO Open Competitie XS-beurs van maximaal 50.000 euro. Eén van de onderzoeken gaat over hoe samen muziek maken samenwerking kan versterken. Lees hier over alle vijf projecten.

A recent study on reintroduced tigers in Panna Tiger Reserve in India reveals that risks from tigers increased more because of human behaviour and people's livestock husbandry practices.

The mission of our group is understanding how science communication works to improve the interaction between science and society. We believe better science communication can improve our society and engage many different groups with science, also improving science.

A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…

Twee onderzoeksconsortia waarin vooraanstaande Leidse wetenschappers samenwerken met onderzoekers van andere Nederlandse onderzoeksinstituten, krijgen Zwaartekrachtsubsidies van samen ruim 50 miljoen euro van het Ministerie van OCW.

To contribute to the body of knowledge aiming at a better coverage of ecosystem service assessment in LCA studies, this thesis dives into the challenges of incorporating existing ecosystem service methods within the impact assessment phase of the conventional LCA framework.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

In this work, I explore the creation of new methods that optimize simulations of the gravitational N-body problem. Specifically, I take advantage of the recent popularity of Machine Learning methods to find tools that can suit this problem.

Humans perceive the real world through their sensory organs: vision, taste, hearing, smell, and touch. In terms of information, we consider these different modesalso referred to as different channels of information or modals.

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

Around the world, mindfulness has become big business. This course combines conventional scholarly inquiry from multiple disciplines with experiential learning to provide a responsible, comprehensive, and inclusive education about mindfulness as a contemporary phenomenon.

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

Promotor: Prof.dr. C.U. Keller, Co-promotor: Frans Snik

Structural variants (SVs) are the hidden architecture of the human genome, and are critical for us to understand diseases, evolution, and so on.

Discover the master program Health, Ageing and Scoiety at Leiden University and contribute to a future proof health care system. Read more.

Op 23 juni 2020 verdedigde Santy Kouwagam haar proefschrift 'How lawyers win land conflicts for corporations: Legal Strategy and its influence on the Rule of Law in Indonesia'. Het promotieonderzoek is begeleid door promotoren prof.dr. A.W. Bedner en prof.dr. C.E. von Benda-Beckmann.

In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.

Food security is challenged by a growing global population and by climate change. Drought and soil salinity are considered the most important ones that inhibit crop yield and distribution. Worryingly, climate change is predicted to increase not only their frequency and severity, but also their co-occurrence,…

With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

Promotor: F. Arbab, R. De Nicola, Co-Promotor: M. Tribastone