663 zoekresultaten voor “biological soft matter physics” in de Publieke website
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Giant barrel sponges in diverse habitats: a story about the metabolome
Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.
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Applications of Natural Deep Eutectic Solvents to Extraction and Preservation of Biomolecules
The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.
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Synthetic Study on ADP-ribosylation
This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.
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Design and development of conformational inhibitors and activity-based probes for retaining glycosidases
Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.
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Towards automated identification of metabolites using mass spectral trees
Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers
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Bacterial glycomimetics: synthesis and applications
This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.
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Histone-DNA assemblies in archaea. Shaping the genome on the edge of life
All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).
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Measuring what Matters
Promotie
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Translational Symmetry Breaking in Holographic Strange Metals
In this thesis, we have used numerical approaches to study the effects of translational symmetry breaking on strange metallic systems as realised by the holographic duality.
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Coherent dynamics in solar energy transduction
Promotor: Prof.dr. H.J.M. de Groot, Co-promotor: Francesco Buda
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Strategies for Mechanical Metamaterial Design
On a structural level, the properties featured by a majority of mechanical metamaterials can be ascribed to the finite number of soft internal degrees-of freedom allowing for low-energy deformations.
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Molecular electronics: Controlled manipulation, noise and graphene architecture
Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.
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Nederlands Instituut Marokko
Marokko en Nederland zijn nauw met elkaar verbonden. De aanwezigheid van een gemeenschap van Nederlanders met Marokkaanse wortels past binnen een gedeelde geschiedenis van vier eeuwen maatschappelijke en academische uitwisselingen. Als instelling die midden in de Marokkaanse maatschappij en het universitaire…
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Shape Analysis for Phenotype Characterisation from High-throughput Imaging
We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.
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Inhibitor discovery of phospholipases and N-acyltransferases
In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.
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Developing metabolomics for a systems biology approach to understand Parkinson's disease
Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…
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Understanding functional dynamics and conformational stability of beta-glycosidases
Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.
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Direct and two-step activity-based profiling of proteases and glycosidases
Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel
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Systems diagnosis of chronic diseases, explored by metabolomics and ultra-weak photon emission
Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang
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Cosmic particle acceleration by shocks and turbulence in merging galaxy clusters
In this thesis, I study the formation of large-scale structure and the physics of particle acceleration at large scales (~Mpc).
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Weighing the Dark: Cosmological Applications of Gravitational Lensing
Promotor: K. Kuijken, Co-Promotor: H. Hoekstra
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The synthesis of mannose-derived bioconjugates and enzyme inhibitors
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee
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mRNA and drug delivery with lipid-based nanoparticles
This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.
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Discovery and characterization of new glucosylated metabolites: pathophysiological consequences
Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.
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Transcutaneous vagus nerve stimulation reduces spontaneous but not induced negative thought intrusions in high worriers
Transcutaneous vagus nerve stimulation (tVNS) was tested in chronic worriers. tVNS may reduce spontaneously occurring negative thought intrusions. After a worry induction, there was no longer an effect of tVNS. tVNS did not affect physiological responding to worrying.
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Insolvency Office Holder-project
It researches (the possibilities for) the development of a set of principles and best practices for insolvency office holders by comparing multilateral treaties and soft law recommendations and national legislation within Europe.
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Evolutionary molecular dynamics
This thesis introduces the concept of
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Synthesis of well-defined ADP-Ribosylated biomolecules
Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov
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Spin-label EPR Approaches to Protein Interactions
Promotor: Prof.dr. E.J.J. Groenen, Co-Promotor: M. Huber
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Novel Protecting Group Strategies in the Synthesis of Oligosaccharides
The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.
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Iminosugars as glucosylceramide processing enzymes inhibitors: design, synthesis and evaluation
This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.
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Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo
Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.
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Patterns in natural systems
Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris
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Alexey Boiarskyi benoemd tot hoogleraar
Theoretisch natuurkundige en kosmoloog Alexey Boiarskyi is per 1 oktober benoemd tot hoogleraar.
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Gaatjes prikken voor supergeleiding
In hun zoektocht naar materialen die zonder weerstand stroom geleiden bij gematigde temperaturen, sleutelen wetenschappers meestal aan de chemische samenstelling. Leidse natuurkundigen komen nu met een radicaal nieuwe benadering: gaatjes prikken in een periodiek patroon. Publicatie in SciPost.
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Anne Meeussen wint Ehrenfest-Afanassjewa proefschriftprijs 2021
Anne Meeussen, die in mei 2021 cum laude promoveerde op programmeerbare materialen, heeft de tweede Ehrenfest-Afanassjewa-prijs gewonnen, uitgereikt door de Dutch Physics Council.
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Breaking of ensemble equivalence for complex networks
For many system in statistical physics the microcanonical and canonical ensemble are equivalent in the thermodynamic limit, but not for all.
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Frontiers of Nanoscience (NanoFront)
Kunnen we van quantum-verrassingen quantum toepassingen maken? Kunnen we het leven onderzoeken en opbouwen vanuit de nano-schaal?
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Contact
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Dynamics and radiation from tidal disruption events
When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).
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The distribution of stellar mass in galaxy clusters over cosmic time
Promotor: Prof.dr. K.H. Kuijken, Co-Promotor: H.Hoekstra
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Scattering and absorption in 2D optics
Scattering of light in the presence of nano-structured materials, i.e. with features in the order of the wavelength of the light or smaller, reveals details of how light interacts with matter at the nanoscale.
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The alignment of galaxies across all scales
Galaxy intrinsic alignments induce a major astrophysical contamination to weak gravitational lensing measurements and need to be modelled and mitigated when extracting cosmological information from such measurements.
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Geometry and Topology in Active and Driven Systems
The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).
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Visualizing strongly-correlated electrons with a novel scanning tunneling microscope
Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.
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Development matters – Longitudinale ontwikkeling van hersenen en gedrag
Congres/symposium
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Probing quantum materials with novel scanning tunneling microscopy techniques
This thesis described the development of novel scanning tunneling microscopy techniques to investigate strongly correlated electronic states in quantum matter.
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Integer and fractional quantum hall effects in lattice magnets
Promotor: Prof.dr.ir. J.W.M. Hilgenkamp, Prof.dr. J. van den Brink
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Biological evaluations of nanocarriers to improve the effectiveness of colorectal cancer treatment
Promotie
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De rijke fysica van tandpasta en mayonaise
Korrelige materialen als tandpasta, zand, scheerschuim en mayonaise verstijven niet altijd als ze dicht samengepakt worden, hebben onderzoekers onder leiding van de Leidse natuurkundige prof.dr. Martin van Hecke ontdekt. Zelfs als deze materialen zich verzetten tegen samendrukking, bieden zij vaak geen…