Ice, the solid state of water, plays an important role on our planet as well as the entire universe.Despite the fact that an individual water molecule has a very simple structure, its chemical bonding in the solid phase can be surprisingly complex.

Op 8 juli 2020 verdedigde Andres Sarmiento Lamus zijn proefschrift 'The Proliferation of Dissenting Opinions in International Law'. Het promotieonderzoek is begeleid door promotoren prof.dr. L.J. van den Herik en prof.dr. Y.A.A.S. Radi (UCLouvain).

Promotor: P. T. de Zeeuw, Co-promotor: N. Neumayer; G. van de Ven

Promotor: T.H. Oosterkamp

Reducing greenhouse gas emissions is one of the most pressing challenges that humanity faces in the coming decades.

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

Onder welke omstandigheden kan dwangdiplomatie een staat dwingen zijn kernwapenprogramma op te geven?

Linde Desmaele onderzoekt de rol van Amerikaanse tactische kernwapens in Europa. Zij stelt dat deze wapens voornamelijk dienen als instrumenten voor bondgenootschapsbeheer.

In dit artikel wordt onderzocht hoe educatieve risicocommunicatie de openbare veiligheid kan ondersteunen tijdens nucleaire noodsituaties.

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

Protein–protein complexes are formed via transient states called encounter complexes that greatly influence the formation of the stereospecific complex.

By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.

Gold nanorods are biocompatible nanoparticles that present an excellent two-photon signal that can be used to get high spatial resolution inside living cells. Gold nanorods are photostable and therefore can be followed inside cells for long time, with possible applications as trackers in live cells.

Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.

Promotie

Aan de opleidingen van het Centre for Professional Learning op het gebied van Terrorisme, Recht en Veiligheid zijn verschillende (research) fellows verbonden. De fellows geven advies over de inhoud van het curriculum en de verbinding tussen wetenschap en praktijk.

De onderzoeksgroep Intelligence and Security houdt zich bezig met inlichtingen en veiligheid binnen de Europese Unie. De aanpak is interdisciplinair en weerspiegelt de brede benadering van het ISGA. Inzichten uit onder meer ethiek, geschiedenis, recht, politicologie, psychologie en sociologie worden…

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

ISGA in Den Haag biedt bachelor- en masteropleidingen, minoren en onderzoek in security studies, cybersecurity, terrorisme, diplomatie en actuele veiligheidsvraagstukken. Focuspunten: bachelor, master, minoren, onderzoek, security studies, cybersecurity, terrorisme, diplomatie, veiligheidsvraagst…

A plasma is an ionized gas with very low electrical resistivity. As such, magnetic field lines are 'frozen in' and move with the fluid. Magnetic field lines that are linked, knotted and tangled, cannot be undone by the fluid motions.

Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

This dissertation is an experimental study of laser-generated, atmospheric pressure, transient toroidal helium plasmas.

Promotor: W. Jaffe, Co-promotor: K. Meisenheimer

Lezing

Promotor: J.S. Kaastra Co-promotor: E. Constantini

Promotor: Prof.dr. M. Ubbink

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

In this thesis, single-cell approaches were applied to characterize the impact of aging on the immunological B cell landscape in different models of atherosclerotic cardiovascular disease, with the goal to identify and study new B cell-associated biomarkers and therapeutic targets to halt atherosclerosis…

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

The thesis addresses the long-term dynamical evolution of hierarchical multiple systems.

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Promotor: H.J.M. de Groot

Dinsdag 8 januari, tijdens de nieuwjaarsreceptie, werden de winnaars bekend gemaakt van de Jongbloed facultaire scriptieprijs 2012-2013.

Dr. Bela Bode ontvangt van de Alexander von Humboldt-stichting de Feodor Lynen onderzoeksbeurs voor de ontwikkeling van nieuwe methoden voor verbetering van het signaal in de vaste stof NMR. Hij streeft naar een specifiek analytisch instrument voor oppervlakte-studies en onderzoek over membranen en…

Speciale versterkstoffen kunnen MRI-scanners honderden malen gevoeliger maken. Leidse fysici hebben nu een methode gevonden om hun efficiëntie te toetsen. Gevoeligere MRI-scans kunnen bijvoorbeeld taaislijmziekte of Parkinson begrijpelijker maken. Publicatie op 18 januari in PCCP.

We zijn bedroefd door het overlijden van Nicolaas Bloembergen, winnaar van de Nobelprijs voor de Natuurkunde in 1981, op 97-jarige leeftijd.

Leidse onderzoekers hebben minuscule bewegingen gevonden in het laccase-enzym. Deze ontdekking kan leiden tot de ontwikkeling van veel efficiëntere biobrandstofcellen. Publicatie in Biophysical Journal.