1,881 zoekresultaten voor “modelling 20” in de Publieke website
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Quantitative pharmacology of antimicrobials
Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.
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The flux and flow of data: connecting large datasets with machine learning in a drug discovery envirionment
This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…
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Nieuwe publicatie van Christa Tobler over alternatieve modellen van EU-integratie
Na de conferentie van de 20e Oostenrijkse Dag van het Europees recht in september 2021 aan de Universiteit van Liechtenstein in Vaduz, zijn de academische papers van de conferentie nu in boekvorm gepubliceerd. Tot de bijdragen aan het boek behoort een hoofdstuk van Christa Tobler: Christa Tobler, ‘Finally…
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Zsuzsa Bakk
Faculteit der Sociale Wetenschappen
z.bakk@fsw.leidenuniv.nl | +31 71 527 8032
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Tales Yamamoto
Wiskunde en Natuurwetenschappen
t.m.yamamoto@cml.leidenuniv.nl | +31 71 527 2727
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Roy de Kleijn
Faculteit der Sociale Wetenschappen
kleijnrde@fsw.leidenuniv.nl | +31 71 527 3915
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Mariana Braz Pires
Wiskunde en Natuurwetenschappen
m.braz.pires@cml.leidenuniv.nl | +31 71 527 2727
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Multiscale mathematical biology of cell-extracellular matrix interactions during morphogenesis
During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.
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Database vol 3D-modellen: ‘Misschien helpt het ons inclusiever met restitutie om te gaan’
Computers van wetenschappers staan inmiddels vol met ingewikkelde 3D-modellen, maar voor de uitwisseling van de gegevens is nog geen standaard ontwikkeld. Een nieuwe database moet daar verandering in brengen. Buitenpromovendus Liselore Tissen ontvangt een beurs om er namens Universiteit Leiden (en TU…
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Galaxy formation and the structure of the Universe
Promotores: Prof.dr. J. Schaye, Prof.dr. S.D.M. White (MPA Garching)
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The integration of meta-analysis and classification & regression trees: meta-CART
In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).
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PI3K signaling and adherens junctions in invasive lobular breast cancer
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.
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Quantifying the toxicity of mixtures of metals and metal-based nanoparticles to higher plants
Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver
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Guiding evolutionary search towards innovative solutions
Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)
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Advances in Survival Analysis and Optimal Scaling Methods
This thesis is based on five papers on several topics.
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LAW #20 in World University Rankings 2018
De Times Higher Education (THE) World University Rankings 2018 zijn gepubliceerd en dit jaar is voor het eerst het Subject ‘LAW’ meegenomen. Onze faculteit staat in deze ranking op nummer 20.
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Software development by abstract behavioural specification
The development process of any software has become extremely important not just in the IT industry, but in almost every business or domain of research.
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Leiden University wins best position paper at the 2019 Model ICAO
The 2019 Model ICAO took place from 21-24 May at the ICAO headquarters in Montreal.
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Lezing Niko Tinbergen, zondag 20 september
Ter ere van Nobelprijswinnaar en etholoog Niko Tinbergen organiseert de Universiteit Leiden in samenwerking met het NRC Handelsblad, NWO, Naturalis en Museum Boerhaave jaarlijks de Tinbergenlezing.
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Chris Flinterman
Faculteit der Geesteswetenschappen
c.h.f.flinterman@hum.leidenuniv.nl | +31 71 527 6713
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MULTIPLY - MULTIscale SENTINEL land surface information retrieval Platform
Aim: To develop and enable application of a practical, flexible, user-friendly platform to provide the scientific community with a tool to generate land surface products and its associated uncertainties and exploit these for data-intensive science.
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De Nederlandse Ig Nobel Night, 20 september
De Ig Nobelprijzen worden jaarlijks op Harvard University uitgereikt aan tien wetenschappers die met hun onderzoek mensen ‘eerst aan het lachen maken en daarna aan het denken zetten’. Dit jaar is voor de allereerste keer de 22e Ig Nobel Prijsceremonie op donderdag 20 september real time – op een groot…
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Global fitness maximising approaches to evaluate the trade-offs involved in the evergreen and deciduous conundrum
Which traits and/or trade-offs determine benefits of being deciduous or evergreen?
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Verslag vergadering 991 - 20 november 2014
Op 20 november vond de lezing van Prof.dr. Han de Winde met voorbroodje plaats. Naast de vaste schare NGL leden waren veel jonge alumni van de Faculteit der Wiskunde en Natuurwetenschappen tot het onderwerp aangetrokken. Ze wilden graag een academische lezing bijwonen omdat ze niet allemaal in de wetenschap…
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Interactions from lipid membrane deformations
Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.
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Protein arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…
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Stochastic resetting and hierarchical synchronisation
Stochastic resetting is simple enough to be approached analytically, yet modifies stochastic processes in a non-trivial way.
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Proteins in harmony: Tuning selectivity in early drug discovery
This thesis describes the importance of being able to control the selectivity of potential drug candidates.
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Actors at work
Promotor: F.S. de Boer Co-promotor: P. T. de Gouw
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NMR studies of protein-small molecule and protein-peptide interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
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Anyonic, cosmic, and chaotic: three faces of Majorana fermions
In my thesis I study Majorana fermions from three different perspectives. The first one corresponds to non-interacting Majorana fermions that, however, pose non-trivial topological properties. The second one corresponds to strongly interacting Majoranas and the third to relic neutrinos. No one knows…
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Calculated Moves: Generating Air Combat Behaviour
By training with virtual opponents known as computer generated forces (CGFs), trainee fighter pilots can build the experience necessary for air combat operations, at a fraction of the cost of training with real aircraft.
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Improving vegetation representation in Multi-sensor Earth Observation Products through phenology and trait-based priors
What are the behaviours of plant traits throughout various points in the growing season in a radiative transfer model framework and how well can this knowledge be integrated through data assimilation to provide priors for robust local and global vegetation products and analysis?
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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Ga mee op zoek naar het geheim van ‘Marokkaanse model’ : Studiereis islam, gender, en burgerschap
Marokko is een van de weinige landen in Noord-Afrika die aan de Arabische lente een vreedzame vorm heeft weten te geven door het pad van brede, gestage politieke hervormingen op te gaan. De Marokkaanse overheid verklaart de relatieve maatschappelijke rust daarnaast ook door haar islampolitiek, gericht…
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Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
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Blowup in the complex Ginzburg-Landau equation
Promotor: Prof.dr. A. Doelman, Co-promotor: V. Rottschäfer
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G-zips and Ekedahl-Oort strata for Hodge type Shimura varieties
Promotores: S.J. Edixhoven, F. Andreatta
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Multi-Biomarker Pharmacokinetic-Pharmacodynamic Relationships of Central Nervous Systems Active Dopaminergic Drugs
Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: M. Danhof, Co-promotor: E.C.M. de Lange
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Mirko Forastiere
Wiskunde en Natuurwetenschappen
m.forastiere@cml.leidenuniv.nl | +31 71 527 2727
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Sebastiaan Deetman
Wiskunde en Natuurwetenschappen
s.p.deetman@cml.leidenuniv.nl | +31 71 527 5616
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Ruben Huele
Wiskunde en Natuurwetenschappen
huele@cml.leidenuniv.nl | +31 71 527 FLEX
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Meer dan 20 nieuwe grafheuvels ontdekt op de Veluwe
Meer dan 50 vrijwilligers onderzochten tussen 11 en 15 oktober samen met studenten archeologie van de Universiteit Leiden verschillende heuvels in het Speulder- en Sprielderbos nabij Putten. Dat deden zij in het kader van Erfgoed Gezocht, een citizen science project van Erfgoed Gelderland en de Universiteit…
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On transport properties of Majorana fermions in superconductors: free & interacting
Majorana fermions in superconductors are the subgap quasiparticle excitations that are their own antiparticles.
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Liposome-based synthetic long peptide vaccines for cancer immunotherapy
Promotores: Wim Jiskoot; Ferry Ossendorp
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Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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Uniform infinite and Gibbs causal triangulations
Promotor: Richard D. Gill
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Lipid mediated colloidal interactions
The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.