1,917 zoekresultaten voor “professional development of teachers” in de Publieke website
-
Temminck's Order. Debates on Zoological Classification: 1800-1850
“Temminck’s Order” is the scientific biography of Coenraad Jacob Temminck (1778–1850), a Dutch naturalist and the first director of ’s Rijks Museum van Natuurlijke Historie in Leiden.
-
Novel formulations and delivery strategies for inactivated polio vaccines : new routes with benefits
This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.
-
Inhibitors and activity-based probes for β-D-glucuronidases, heparanases and β-L-arabinofuranosidases
Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.
-
Biomimetic models of [NiFe] hydrogenase for electrocatalytic hydrogen evolution
The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.
-
Multi-Biomarker Pharmacokinetic-Pharmacodynamic Relationships of Central Nervous Systems Active Dopaminergic Drugs
Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.
-
Indicators for "decoupling"
Indicators to measure progress in de-linking economic growth and environmental pressure.
-
CO2-Calculator
Development of GHG calculator for bio-electricity and heat.
-
Probing quantum materials with novel scanning tunneling microscopy techniques
This thesis described the development of novel scanning tunneling microscopy techniques to investigate strongly correlated electronic states in quantum matter.
-
Computational Approaches to Disease, Signaling and Drug Targets
The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.
-
Armin Cuyvers
Van onderwijs tot een verrijkende ervaring
-
Developing systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer
-
Clinically Suspect Arthralgia, Unraveling the Development of Rheumatoid Arthritis
Promotie
-
Online Open Dag voor Professionals
Of het nu gaat om bijspijkeren van een taal, een actualiteitencursus voor juristen tot aan een masteropleiding over cybersecurity. Laat je inspireren tijdens de Online Open Dag voor Professionals op 2 november.
-
‘Defense, diplomacy, development… and disillusions’
De opzet van de Britse en Nederlandse missies in Zuid-Afghanistan werd ingegeven door Westerse vooringenomenheid, in plaats van door een gedegen, open analyse. Tot deze slotsom komt politicologe en majoor Mirjam Grandia in haar promotieonderzoek naar de Britse en Nederlandse besluitvorming rond de missies…
-
Assembling anisotropic colloidal building blocks
This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.
-
Understanding the Heterogeneity of Corporate Entrepreneurship Programs
In today's volatile market environments, companies must be able to continuously innovate. In this context, innovation does not only refer to the development of new products or business models but often also affects the entire organization, which has to transform its structures, processes, and ways of…
-
Small-molecule inhibitors of bacterial metallo-β-lactamases
The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).
-
Data-Driven Machine Learning and Optimization Pipelines for Real- World Applications
Machine Learning is becoming a more and more substantial technology for industry.
-
Risks to Health and the Environment Related to the Use of Lead in Products
The aim of this project was to estimate emissions from lead products-in-use for the past, the present and the future and assess the development of toxicological risks associated with these products.
-
Complex Patterns in Streams
The goal of the project is the development of stream mining techniques for complex patterns such as graphs. We will try to extend the existing state-of-the-art techniques into two, orthogonal directions: on the one hand, the mining of more complex patterns in streams, such as sequential patterns and…
-
Studying the Benefits of Using UML on Software Maintenance: an Evidence-Based Approach.
Including modelling as part of software development appears to have various benefits.
-
Developmental effects of polystyrene nanoparticles in the chicken embryo
There is concern about the threat that nanoplastics (NPs) may pose to both wildlife and humans. This thesis explores the mechanisms of toxicity of polystyrene nanoparticles (PS-NPs) in chicken embryo.
-
First-pass and systemic metabolism of cytochrome P450 3A substrates in neonates, infants, and children
Growth and development affect the metabolism of drugs administered to neonates, infants, and children.
-
Plural Medical System in Pirgos and Praitoria for Community Health Development in Rural Crete, Greece
Promotor: Prof.dr. L.J. Slikkerveer
-
Innovative (electro-driven) sample preparation tools for metabolomics study of muscle aging
This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.
-
Peptide-based probes for protein N-Methyltransferases
The work described in this thesis focuses on the development of linear or cyclized peptide probes against protein N-methyltransferases to characterize their specific binding behavior, providing further binding details for inhibitory activity study.
-
Discovery and characterization of new glucosylated metabolites: pathophysiological consequences
Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.
-
Algorithm for Structural Variant Detection
Structural variants (SVs) are the hidden architecture of the human genome, and are critical for us to understand diseases, evolution, and so on.
-
Het toegevoegde risico van grootte
Wat zijn de risico's van nanodeeltjes?
-
Exploring the mechanisms of metastatic onset for novel treatment strategies
This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.
-
Mitochondria in chemical-induced toxicity
Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…
-
Chemical genetic approaches for target validation
Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.
-
CERA - Certification of Raw Materials
CERA (CErtification of RAw Materials) is a four-year project that will develop a standardized certification scheme ensuring environmental, social and economic sustainability in extraction, processing, trading and manufacturing of all mineral raw materials. It will guarantee traceability of certified…
-
Onderwijs voor Professionals nu in één overzicht
De nieuwe portal Onderwijs voor Professionals is live. Hier vinden professionals die hun horizon willen verbreden het volledige aanbod van opleidingen, cursussen en masterclasses van de Universiteit Leiden.
-
Young professionals terug in de collegebanken
Campus Den Haag verwelkomde een groep young professionals ter ere van de viering van 444 jaar Universiteit Leiden.
-
Professionals ronden succesvol leergang Public Affairs af
20 Professionals hebben deze week de leergang Public Affairs succesvol afgerond, van harte gefeliciteerd! De leergang bestaat uit vijf modules met verschillende thema’s en helpt professionals om in een dynamische omgeving effectief invloed uit te kunnen (blijven) oefenen door meer inzicht in politieke…
- Assistant Professor Crisis Governance (1 fte)
- 2 Assistant Professors in Intelligence and Security (1 fte)
-
To explore the drug space smarter: Artificial intelligence in drug design for G protein-coupled receptors
Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…
-
The Metals Programme
Accumulation of metals in economy and environment and its associated risks, within the Netherlands and the EU.
-
Functionalized two-dimensional membranes and materials for solar-to-fuel devices: a multiscale computational approach
In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.
-
Synthesis and applications of cell wall glycopolimer fragments from Staphilococci and Enterococci
Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…
-
Modulation of leukocyte homeostasis in atherosclerosis
Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel
-
Pharmacology based toxicity assessment: towards quantitative risk prediction in humans
Promotor: Prof.dr. M. Danhof
-
Synthesis of Ribitol Phosphate based Wall Teichoic acids
Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.
-
A pharmacognostic study of Vernonia guineensis Benth. (Asteraceae): bioactivity, safety, and phytochemical analysis
Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi
-
Affinity-based profiling of the adenosine receptors
The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.
-
Quantitative modelling of the response of earthworms to metals
Promotor: Prof.dr. W.J.G.M. Peijnenburg
-
Potentiation of Gram-positive specific antibiotics against Gram-negative bacteria through outer membrane disruption
Extending our current arsenal of antibiotics is key to staying ahead in the arms race between humans and resistant bacteria.
-
Acute and chronic pain after cardiac surgery
Promotores: C.A.J. Knibbe, D. Tibboel, Co-Promotor: P. Bruins