Onderzoekers aangesloten bij het Leiden Leadership Centre zijn actieve leden van het PUPOL netwerk. PUPOL is een internationaal academisch netwerk voor publiek en politiek leiderschap. Dit netwerk stimuleert de uitwisseling van ideeën en bevordert gezamenlijk onderzoek tussen wetenschappers gericht…

Feedback van medestudenten op schrijfwerk is net zo leerzaam als die van docenten.

The aim of this thesis was to develop aluminium salt-based nanoparticles that may ultimately be used as adjuvant in human vaccines.

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

In dit proefschrift staan de verschillende vormen centraal die de verwevenheid van onderzoek en onderwijs kan innemen binnen de universiteit, meer specifiek in de faculteit Geesteswetenschappen. Algemeen wordt erkend dat een sterke verwevenheid van onderzoek en onderwijs belangrijk is, maar het was…

Students with learning problems experience difficulties in reading, writing, and content-area learning into and throughout their secondary-school years

Op 3 september promoveert Adrian Stenton. Het Leiden University Centre for Linguistics feliciteert Adrian!

Onderzoekers van Leiden University en Solid Sustainability Research hebben een nieuwe studie gepubliceerd in PLOS Climate over de banden tussen Nederlandse universiteiten en de tabaksindustrie. Met dit onderzoek willen zij bijdragen aan de lopende discussie over relaties met de fossielebrandstoffens…

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

Promotor: J. A. Bouwstra

Promotores: Prof.dr. B.R. Katzy, Prof.dr. K. Sailer (Munich University)

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.

Promotor: T. Hankemeier, Co-promotor: T.H. Reijmers

Promotor: F.J. van Lunteren, E. Jorin

Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

Cardiovascular diseases are a leading cause of death worldwide, and better models are urgently needed for disease progression studies and drug development.

The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

In this thesis the links between allergy and intestinal health, the gut microbiome (GM), and external factors were studied by exploring the metabolome in longitudinal clinical studies and in vitro models.

Het schrijven van het profielwerkstuk is voor de meeste leerlingen op de middelbare school een grondige kennismaking met het doen van onderzoek. Maar hoe pak je dit nu aan? En vooral als je dit ook nog in het Engels moet doen omdat je tweetalig onderwijs volgt of een extended essay maakt voor je International…

Tijdens de najaarsconferentie van INSOL Europe Academic Forum in Berlijn is Anthon Verweij, promovendus bij de afdeling Bedrijfswetenschappen, benoemd tot secretaris van het INSOL Europe Academic Forum. Anthon heeft daarbij de werkzaamheden overgenomen van professor Paul Omar van Nottingham Trent Un…

Het CPB Netherlands Bureau of Economic Policy Analyses heeft prof. dr. Koen Caminada met ingang van 1 januari 2017 herbenoemd tot Academic Partner van de sector Publieke Financiën, in het bijzonder het programma Overheidsfinanciën.

Promotor: W. Jiskoot, Co-promotor: A. Hawe

Interview in Academic Stories met Daniela Kraft over zelfbouwende zachte materie, nanorobots, het belang van vrouwelijke rolmodellen in de wetenschap en de unieke vrijheid en steun die ze in haar instituut ervaart.

In this thesis, we developed new ways to use a technique called electroextraction (EE) to extract charged molecules from one liquid into another using an electric field.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

Nederlandse kennisinstellingen gaan samen met de farmaceutische en biotechindustrie het ontdekken en ontwikkelen van medicijnen versnellen. Om de ‘lab-to-life’-kloof te dichten hebben de Universiteit Leiden en het LUMC als penvoerders een aanvraag ingediend bij het Nationaal Groeifonds.

Het college van bestuur kan met groot genoegen melden dat per 1 januari 2025 Joanne van der Leun voor de universiteit aan de slag is gegaan als Academic Lead International Affairs.

Jonge wetenschappers van alle disciplines aan elkaar knopen, dat is in een notendop de missie van de Young Academy Leiden. En dat doet de prille organisatie nu al met succes, bleek wel tijdens de eerst Young Academic Lunch van de Faculteit der Sociale Wetenschappen.

Cell-based medicinal products (CBMPs), such as CAR T cells, are highly complex biopharmaceutical products offering various treatment options for serious illnesses such as cancer or autoimmune diseases.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

M. Danhof, Co-promotores: J. Freijer, A. Yassen

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

This thesis investigated miniaturized mass spectrometry (MS)-based analytical methods to address challenges in analyzing biomass-restricted biological samples.

Growth and development affect the metabolism of drugs administered to neonates, infants, and children.

Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh