The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.

Bacteria are highly complex and diverse organisms that have adapted to survive in ecological niches ranging from the most extreme to the most heterogeneous environments.

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

Genen voorspellen of je een risico loopt om ziek te worden, omgevingsfactoren geven vaak het laatste duwtje: voeding, luchtvervuiling, leefstijl, stress. Het exposoom als boosdoener, en als kans. In Leiden wordt er op grote schaal onderzoek naar gedaan. Thomas Hankemeier, hoogleraar Analytische Bio¬wetenschappen,…

A complex community of microbes develops in the infant gut shortly after birth. We call this community the infant gut microbiota. The microbiota influences the health of the infant, which makes the composition and function of the infant gut microbiota an important topic to study.

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken