Bacteria are highly complex and diverse organisms that have adapted to survive in ecological niches ranging from the most extreme to the most heterogeneous environments.

Promotor: E.F. Smets Co-promotor: J. Geml

Promotor: E.F. Smets, Co-promotor: J. Geml

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

Almost all bacteria are enveloped by a cell wall that provides cellular protection.

Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

Promotor: Prof.dr. T. Schmidt

Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

Op deze pagina vindt u de opnames van de online This Week's Discoveries vanaf 12 mei 2020 en een lijst sprekers vanaf oktober 2015.

Promotores: Prof.dr.G.R. de Snoo and Dr. R. Heijungs

Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

In populations with a seed-bank, individuals can temporarily become dormant and refrain from reproduction until they can become active again. The repository of all dormant individuals in the population is called the seed-bank. Seed-banks are observed in many taxa, including plants, bacteria and other…

Muziek van een composteerbare cello, foto’s en geurtjes van schimmels en een geweven wandkleed. Het zijn een aantal voorbeelden uit Super Organism, het kunstproject van Suzette Bousema waarin je de ondergrondse schimmelwereld met al je zintuigen kunt beleven. Leids milieuwetenschapper Nadia Soudzolovskaia…

Herstel van de natuur op uitgeputte landbouwgrond en in natuurgebieden verloopt moeizaam. ‘Bodemtransplantatie’ kan mogelijk uitkomst bieden. Dat betoogt Martijn Bezemer, hoogleraar Ecologie van Plant-Microbe-Insect interacties. Oratie op 18 december.

Een leefbare aarde. Meer biodiversiteit. En verstandig omgaan met resources. Bij het CML willen we impact maken met ons onderzoek én onderwijs. Op deze website lees je hoe we dat doen.

We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.

This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

Promotor: Prof.dr. G.P. van Wezel

Stel: je moet reizen, maar je hebt geen auto en je bent volledig blut. Wat doe je? Liften natuurlijk! Leidse biologen hebben ontdekt dat bepaalde bacteriën precies deze tactiek toepassen: hun sporen springen op beweeglijke bacteriën en gebruiken die als taxi. Zo kunnen ze de juiste omgeving bereiken…

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Promotor: G.P. van Wezel

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

Promotor: Prof.dr. G.P. van Wezel

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. M. van der Zee

This ecological community has long been known to affect host biology, and their diverse roles have been further clarified in recent years following numerous studies of animal:microbiota interactions in diverse systems.

Promotor: Prof.dr. J. Kuiper

Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).

Control of infectious diseases poses continuous challenges for human health.

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.

This thesis aims to investigate the effect of tripartite interaction between microbial inoculants, the plant, and herbivore insects on the rhizosphere microbiome and volatilome. We investigated the rhizosphere microbiome and volatilome of tomato plants exposed to insect herbivory and/or inoculated with…

How can we quantify the density of species within a community through environmental DNA concentrations?