412 zoekresultaten voor “chemical industry” in de Publieke website
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Phenotypic engineering of photosynthesis related traits in Arabidopsis thaliana using genome interrogation
Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal
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Improvisations in phototrophy
Microbial rhodopsins are photosensitive pigments implemented in the growth and adaptation of a large population of microorganisms.
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Understanding the uptake and internal distribution of metallic nanoparticles in Danio rerio larvae
The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.
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Not so smooth after all: resolving dust and gas structures in protoplanetary disks
A large diversity of exoplanetary systems has been found, but it is still unclear what drives this diversity.
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Water related adsorbates on stepped platinum surfaces
Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink
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Development of a Dynamic Substance Stock Model
Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.
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Rationally designed peptide based functional biomaterials
Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros
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Photothermal studies of single molecules and gold nanoparticles: vapor nanobubbles and conjugated polymers
Promotor: M.A.G.J. Orrit
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Many objective optimization and complex network analysis
This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.
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Photocatalytic redox reactions at the surface of liposomes
Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet
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Squaramide-based supramolecular polymers
Supramolecular polymers are class of materials that are formed by non-covalent interactions such as hydrogen bonding, π-π interactions, electrostatic interactions and the hydrophobic effect.
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Stereoelectronic and conformational effects in oxocarbenium, iminium and iminosugar ammonium ions
Promotores: Prof.dr. G.A. van der Marel, M. van Heel
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Development of automatic image analysis methods for high-throughput and high-content screening
Promotor: Prof.dr. B. van de Water
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Electrocatalysis of CO2/CO interconversion and Hydrogen Evolution in Bicarbonate Buffers
Bicarbonate buffer is largely found in nature due to its ability to regulate pH variations around neutral values. As the pH changes, so does the speciation of the buffer.
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Zipping into Fusion
Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros
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Quantum computation with Majorana zero modes in superconducting circuits
Promotor: Prof.dr. C.W.J. Beenakker
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Protoplanetary disk anatomy: examining the structure and chemistry of planetary birthplaces with simple molecules
This thesis examines the link between simple molecules and the underlying structure and chemistry within protoplanetary disks - the birthplaces of planets.
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Bridging the gap between physics and chemistry in early stages of star formation
A dense region of a gaseous and dusty cloud collapses to form a protostar surrounded by a disk and an envelope. This thesis uses both observations and models to study physical and chemical conditions of these protostellar systems which are likely where planets start to form.
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Antibiotic Discovery: From mechanistic studies to target ID
The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.
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Stereoelectronic and conformational effects in oxocarbenium, iminium and iminosugar ammonium ions
Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée
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Giant unilamellar vesicles: An efficient membrane biophysical tool and its application in drug delivery studies
Promotor: A. Kros
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Development of highly accurate density functionals for H2 dissociation on transition metals
Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).
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Sensing Transport
Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.
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Applications of Natural Deep Eutectic Solvents to Extraction and Preservation of Biomolecules
The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.
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Synthetic Study on ADP-ribosylation
This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.
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The puzzle of protoplanetary disk masses
My work focuses on a class of astronomical objects called protoplanetary disks.
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Omics data integration with genome-scale modelling of dopaminergic neuronal metabolism
Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.
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Activity-based protein profiling of glucosidases, fucosidases and glucuronidases
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea
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Compiling and Refining Environmental and Economic Accounts (CREAA)
CREEA is a FP7 project on compiling and refining environmental and economic accounts. The project runs from April 2011 to March 2014.
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Multi-objective Evolutionary Algorithms for Optimal Scheduling
Multi-criteria optimalisatie is een effectieve techniek voor het vinden van optimale oplossingen die een afweging bieden tussen verschillende, tegenstrijdige criteria. Het heeft zijn toepassing gevonden in de wereld om ons heen omdat bij het oplossen van praktische, re¨ele wereld problemen men gewoonlijk…
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EPCEM 2001: Differences in the authorization process of GMOs in the EU and the USA
This report investigates the different approaches in the authorization process of GMOs for commercial use in the European Union and the United States of America. Three main aspects are considered and analyzed as potential causes of differences in the authorization process of GMOs for commercial use.…
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Evaluating Asian aquaculture using Life Cycle Assessment (LCA)
Are there significant differences among the environmental impacts resulting form the production of Asian aquaculture commodities and what are the main causes for these?
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Freezing conditions in warm disks: snowlines and their effect on the chemical structure of planet-forming disks
Promotie
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The Infrared Spectrum of Massive Protostars
We have conducted a full spectral line survey of the 3-13 micron region of two massive protostars, AFGL 2591 and AFGL 2136, for the first time at high spectral resolution.
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The holographic glass bead game: from superconductivity to time machines
Promotores: Prof.dr. J. Zaanen, Prof.dr. K.E. Schalm
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Global distribution patterns of distinct mycorrhizal types and ecological drivers of these patterns
What are the global relationships between environmental conditions and abundance of distinct types of mycorrhizal fungi in soil and plant roots?
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Parallel evolution in an invasive plant species: evolutionary changes in allocation to growth, defense, competitive ability and regrowth of invasive
Promotor: Prof.dr. P.G.L Klinkhamer, Co-promotor: K. Vrieling
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Ab initio molecular dynamics calculations on reactions of molecules with metal surfaces
Promotor: Prof.dr. G.J. Kroes
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X-ray spectroscopy of interstellar dust: from the laboratory to the Galaxy
In this thesis, we present new laboratory data of interstellar dust analogues.
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The formation of complex organic molecules in dense clouds-Sweet results from laboratory
Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.
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Electrocatalytic CO2 reduction toward liquid fuels : on heterogeneous electrocatalysts and heterogenized molecular catalysts
With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.
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Lava worlds: characterising atmospheres of impossible nature
Over the last three decades, the discovery of exoplanets has revealed the boundless variety of worlds beyond our own Solar System. Majority of planetary systems contain short-period planets that are larger than Earth but smaller than Neptune.
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Direct and two-step activity-based profiling of proteases and glycosidases
Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel
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The use of computational toxicology in hazard assessment of engineered nanomaterials
Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…
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Sterrewacht Leiden
Sterrewacht Leiden is het sterrenkundig instituut van de Faculteit der Wiskunde en Natuurwetenschappen van de Universiteit Leiden.
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Bioorthogonal Antigens as Tool for Investigation of Antigen Processing and Presentation
In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…
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Abiotic depletion in LCIA
Possible improvements for the assessment of abiotic depletion in LCA.
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Inhibitor Selectivity: Profiling and Prediction
Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.
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Postdoc Computational Modeling for Drug Safety Prediction
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)