The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

This research delves into a region of space known as the interstellar medium (ISM), which is essentially the area between the stars filled with gas and dust.

Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska

Lipid formulations have demonstrated strong potential for nucleic acid delivery,particularly with the success of COVID-19 vaccines. Despite these advances, manyaspects of lipid formulations remain unclear.

An Active Galactic Nucleus (AGN) is a highly luminous region at the center of a galaxy, powered by the accretion into a supermassive black hole and emitting energy from radio waves to gamma rays, often outshining the host galaxy.

Organic amendments applied to agricultural fields can partially offset our carbon emissions to the atmosphere and improve the resilience of agriculture to the effects of climate change. Driving these benefits, however, are complex and poorly understood interactions between organic amendment properties,…

In this thesis, I focused on studying the above- and belowground interactions of J. vulgaris from a plant-soil feedback (hereafter, PSF) perspective. I investigated the temporal variation of negative PSF and examined the effects of root-associated bacteria on plant performance and aboveground herbiv…

Promotor: T. Schmidt

Promotores: G.W. Canters, T.J. Aartsma

This thesis advances our understanding of lipid uptake, a vital first step in lipid metabolism, by developing innovative click chemistry-based tools to study how immune cells internalize lipids.

This thesis involves three topics: benchmarking discrete optimization algorithms, empirical analyses of evolutionary computation, and automatic algorithm configuration.

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf

Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.

Promotor: J.W.M. Frenken

Consequences for sediment stability and seston trapping

Promotores: Prof.dr. J.N. Kok, Prof.dr. C.A. Mandemakers, Co-Promotor: G. Bloothooft

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

Promotor: H.J.A. Röttgering, Co-promotor: M. Haverkorn

This thesis systematically analyzes the physical-chemistry of lipid-graphene interactions with the major objective of reconciliating the variety of results reported in the literature.

The rapidly increasing commercial application of metallic nanoparticles within products will inevitably enhance the amount of NPs being released into soil.

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

Low-carbon (LE) technologies have a significant potential to reduce the total carbon emissions in China.

In this thesis we investigate cosmology and the large scale structure of the Universe using cosmological simulations.

The overall objectives of my thesis are to investigate the dynamics of the sorghum root microbiome and to explore the beneficial effects of the root microbiome on sorghum growth and stress tolerance.

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

This dissertation consists of two parts, with the common theme

Special Issue in: Visual Anthropology, Volume 29, Issue 3, 2016

Promotor: E.F. Smets Co-promotor: J. Geml

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

Spectroscopic studies on fluorescent single molecules in organic condensed matter does not only provide information about the molecule itself, but also its near environment. By suppression of phonon-induced broadening of spectral lines through cooling to low temperatures, small changes in the spectral…

Molecular materials have been a subject of interest in fundamental research and applications for decades, and have been studied as bulk crystals, (thin) films and as individual molecules, due to the large variety in their properties. This dissertation explores pentacene crystals near the two-dimensional…

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Several single-stranded RNA viruses make use of Xrn1-resistant RNAs in their 3’ untranslated regions of their genome RNAs in order to increase their pathogenicity.

In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.

Subproject of the ERC project 'Challenging the Liberal World Order from Within: The Invisible History of the United Nations and the Global South'.

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)

Alien-gekkies lezen Leids theoretisch natuurkundig DNA-onderzoek iets te creatief.

Het onderzoeksproject van Prof.Dr. Arjen Doelman ‘Adaptive Semi-Strong Ecosystem Dynamics’ is geselecteerd voor financiering als een van de 7 onderzoeksprojecten binnen het programma Mathematics of Planet Earth (MPE) van NWO.

De eerste ILS Lunch Seminar van 2017 staat gepland voor maandag 30 januari. Tijdens de ILS Lunch Seminars kunnen alle onderzoekers van de faculteit hun onderzoek presenteren. Het doel is om op een toegankelijke en efficiënte manier op de hoogte zijn van onderzoeken van verschillende onderzoeksprogramma's…

De Cleveringaleerstoel is ingesteld door de Universiteit Leiden ter herinnering aan hoogleraar Rudolph Pabus Cleveringa en zijn moedige optreden in november 1940 tijdens de Duitse bezetting en ter herdenking van de bevrijding in 1945.

In this dissertation (titled: Exploring the Synergies between Transfer in Reinforcement Learning and Procedural Content Generation) we explore how the two research fields named in the title, namely Transfer in Reinforcement Learning (TRL) and Procedural Content Generation (PCG) can synergize togethe…

'Hé kijk, daar staat Rembrandt van Rijn! En is dat niet Beatrix?' Als je goed zoekt loop je tijdens de 444-vossenjacht op 29 juni allerlei beroemdheden uit heden en verleden tegen het lijf.

Op 23 februari 2022 verdedigde Cale Davis het proefschrift 'Prosecutorial Discretion in International Criminal Justice'. Het promotieonderzoek is begeleid door prof.dr. C. Stahn en dr. J.C. Powderly.

Er is veel persaandacht voor het onderzoek van het Levend Lab. Hieronder een kleine greep uit de nieuwsberichten. En bekijk ook vooral de Zembla-aflevering over het Levend Lab.