In this thesis, Quantum computing, norms, and polynomials, we investigate the interplay between quantum mechanics, complexity theory, and functional analysis, three central areas of physics, computer science, and mathematics, respectively.

The zoo of detected exoplanets reveals both the uniqueness of our own Solar System and the complexity of planetary system formation, sparking fundamental questions about how planetary systems form and evolve.

Quantum computing represents a fundamentally new computational paradigm, capable of addressing problems that are intractable for classical computers.

The dissertation offers new tools and insights to computation and modelling of topological phases, with an emphasis on the aperiodic setting.

The rapid expansion of research on human gut microbiome in recent decades has highlighted its role in human metabolism, immune regulation, and behavior.

During the development of the (human) body from a single fertilized egg, organs and structures must form. The development and growth of biological forms is called morphogenesis.

This thesis was embedded in the APELAFICO project and focussed on investigating effects of sound from North Sea offshore wind farms on pelagic fish and harbour porpoise.

All the data stored and processed by our computers is encoded as sequences of zeros and ones, called bits. Quantum computers offer an alternative to this traditional way of encoding and manipulating information.

Adenosine diphosphate ribosylation (ADP-ribosylation) is a fascinating post-translational modification (PTM) that plays a role in a variety of cellular processes and is associated with several diseases, including cancer and viral infections.

Toll-like receptors (TLRs) are central components of the innate immune system, functioning as pattern recognition receptors that detect microbial- and damage-associated molecular patterns and initiate antimicrobial and inflammatory responses.

ELS@Leiden onderzoek omvat een breed scala aan empirisch-juridische projecten die worden uitgevoerd op Leiden Law School, vanuit het perspectief van meerdere disciplines en methodes. Hier kan je de publicaties van onze (voormalige) lab members vinden sinds het begin van het Sector Plan.

Hoe ervaren docentonderzoekers aan Nederlandse hogescholen hun academische identiteit wanneer zij hun onderwijstaken uitbreiden met onderzoek, en hoe navigeren zij de daarmee verbonden roltransities, terwijl zij persoonlijke doelen, institutionele verwachtingen en contextuele mogelijkheden in balans…

We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…

The research presented in this thesis concerns one of the most important questions in software engineering of our time: how can we make sure that software is free from memory safety bugs?

The research in this dissertation aims to optimise blood donation processes in the framework of the Dutch national blood bank Sanquin. The primary health risk for blood donors is iron deficiency, which is evaluated based on donors' hemoglobin and ferritin levels.

This thesis describes the synthesis, analysis of various tetrazine bearing compounds and use in bioorthogonal chemistry.

Seagrass is a marine flowering plant with special adaptations to coastal and marine environments, playing a crucial role in providing a wide range of ecosystem services.

The Sundanese people, the largest ethnic group in West Java, have been using traditional medicine for a long time. Known as ubar kampung, Sundanese indigenous knowledge, beliefs and practices of traditional medicine are based on local people’s knowledge and use of Medicinal, Aromatic, and Cosmetic (MAC)…

In this thesis, single-cell approaches were applied to characterize the impact of aging on the immunological B cell landscape in different models of atherosclerotic cardiovascular disease, with the goal to identify and study new B cell-associated biomarkers and therapeutic targets to halt atherosclerosis…

The confinement of molecular catalysts in metal-organic frameworks has the potential to lead to significant improvements in selectivity, long term activity and catalyst stability.

Met een diploma Koreastudies ben je klaar voor een vliegende start op de arbeidsmarkt. Naast jouw inhoudelijke expertise beschik je na je opleiding namelijk ook over vaardigheden die gewild zijn bij werkgevers. Wil je onderzoeken of lesgeven? Beleid voorbereiden of de strategie bepalen? Werken in sales…

Despite their ecological, cultural, and economic importance, lion (Panthera leo) populations in Kenya are declining rapidly due to retaliatory killings following livestock depredation, depletion of wild prey, habitat loss driven by human activities, climate change, and disease.

This thesis seeks to investigate how cancer-associated mutations affect the pharmacological properties of selected GPCRs—primarily A2AAR and 5-HT2CR—through a combination of ligand binding assays, signaling readouts, kinetic profiling, and cellular functional assays.

Despite substantial progress in understanding tuberculosis (TB), the eradication of the TB epidemic is still far from reach.

In this study, we investigated the electrochemical behavior and surface evolution of Au(111) electrode under different conditions and electrochemical techniques, using a homemade electrochemical scanning tunneling microscope (EC-STM), revealing the intricate interplay between surface roughening, atom…

To answer questions that look beyond individual entities, network science studies the interactions taking place in complex systems. These complex systems can often have temporal information on when an interaction occurs.

In this thesis, we investigate how deep generative models (AI models that can create new designs) can be better utilized for technical and industrial design. Our goal is to generate designs that are not only realistic (plausible), but also efficient, reliable, and usable in complex 2D and 3D applica…