BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

The work in this thesis demonstrates how to obtain an atomic-scale picture of a diverse set of complex surface structures observed using STM, under disparate conditions.

Publicaties die voortkomen uit het AFITE-project

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

Promotor: Prof.dr. J.P. Abrahams

This thesis is about cosmological inflation and its relation to observations.

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

Transport inspectorates are looking for novel methods to identify dangerous behavior, ultimately to reduce risks associated to the movements of people and goods. We explore a data-driven approach to arrive at smart inspections of vehicles.

This thesis concerns the relation bettween the good reduction of Shimura varieties and the associated loop groups.

Promotor: Prof.dr. J.N. Kok

Promotor: S.J. Edixhoven, Co-promotor: K.J. Batenburg

Promotor: W.Th.F. den Hollander, Co-promotor: F.R. Nardi

This thesis examines the impacts and challenges of water use of electric power system. This thesis found that there are large differences in water use of electricity technologies, with hydropower and thermal power being two large water users.

Supply risks are not new. But the aggravation of power conflicts on the international stage coupled with global shifts towards energy transition and digitalization has triggered the next supply risk research era.

Promotor: G.R. de Snoo, Co-promotores: M.G. Vijver, J.P.M. Vink

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

The Low Frequency Array enables studies of low-frequency carbon radio recombination lines with unprecedented sensitivity, spectral and spatial resolution.

Bacteria are highly complex and diverse organisms that have adapted to survive in ecological niches ranging from the most extreme to the most heterogeneous environments.

The International Course on Water Use and Management in Cagayan Valley The Philippines (2011-2015)

De Swahilikust kent een lange geschiedenis van transoceanische islamitische verbindingen die teruggaat tot de 25e eeuw. Toch heeft de boekdrukkunst de wereld veranderd; niet alleen de onze. In dit project worden unieke vormen en archieven van intellectuele geschiedenis ontrafeld die vanuit Zuid-Zuid-verbindingen…

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.

Promotors: Prof.dr. J. Zaanen, Prof.dr.ir. H. Hilgenkamp

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

We investigate how radiation pressure can be used to influence the mechanical motion of a micro-mirror suspended from springs.

This thesis combines field and laboratory studies to address some of the most pressing questions in the field of microplastic research.

Chapter 1,contains the numerical verification of the Birch and Swinnerton-Dyer conjecture for hundreds of Jacobians of hyperelliptic curves of genus 2, 3, 4 and 5.

CT scanning of skeletal remains can tell us about how strong or weak a persons bones were and we can relate that back to diet, activity, and reproductive factors.

Promotor: G.R. de Snoo Co-promotor: C.J.M. Musters

Dit project combineert en heroverweegt al het beschikbare bewijsmateriaal van het Scheurrak SO1 en gebruikt nieuwe archiefdatabases en moderne archeologische technieken om nieuw licht te werpen op de Baltische graanhandel en de Hollandse scheepsbouwindustrie rond de eeuwwisseling.

Promotor: S.J. Edixhoven

This thesis covers several aspects of quantum algorithms for near-term quantum computers and its applications to quantum chemistry and material science.

Humans share meaning through language. Over time, repeated interactions have shaped languages into forms that match our cognitive preferences, making them structured, expressive, easy to learn, and ultimately, meaningful.

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Overzicht van de voornaamste onderzoeksprojecten van het Leids Papyrologisch Instituut.

ELS@Leiden onderzoek omvat een breed scala aan empirisch-juridische projecten die worden uitgevoerd op Leiden Law School, vanuit het perspectief van meerdere disciplines en methodes. Hier kan je de publicaties van onze (voormalige) lab members vinden sinds het begin van het Sector Plan.

Het onderzoeksthema ‘Straftoemeting’ richt zich op straftoemeting in brede zin. Het zwaartepunt ligt op straftoemetingsbeslissingen van rechters, maar ook andere beslissingen die eerder in het strafproces worden genomen, zoals de beslissing over verlenging of beëindiging van de voorlopige hechtenis,…

De onderzoeksgroep Business, Technology & Public Policy van de afdeling Bedrijfswetenschappen van Universiteit leiden houdt zich bezig met het onderzoeken van de dynamische wisselwerking tussen ‘nieuwe’ technologieën en de verschillende belanghebbenden die hiermee interacteren, waaronder consumenten,…

Catherina Wilson is op 1 oktober 2012 aan ons Instituut begonnen met een promotieonderzoek.

Op de LION/Sterrewacht nieuwjaarsborrel heeft prof. Tjerk Oosterkamp de 2016 Hendrik Casimir Prize uitgereikt aan natuurkundestudenten Andrea Peña (Leiden) en Jorrit Hortensius (Delft). The Casimir Research School deelt jaarlijks de Hendrik Casimir Prize uit aan de beste masterstudenten in (technische)…

Binnen de Life in Custody Study wordt grootschalig onderzoek gedaan naar het leefklimaat in Nederlandse penitentiaire inrichtingen (PI’s).

On 24 January 2020, eLaw attended the Annual Conference on Privacy and Data Protection (CPDP) in Brussels, Belgium. The overarching theme of the 13th edition was

What holds people together and what makes them willing to fit within larger political structures? Our project examines this question in the practices of dynastic rulership in Eurasia ca. 1300-1800.