Promotor: W. T. F. den Hollander, F. H. J. Redig

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

One of the most important puzzles in modern astrophysics is the nature of dark matter.

Large carnivores and humans, along with their livestock, have co-existed for thousands of years. However, human population growth and an increase in economic activities are modifying the landscape for large carnivores and their prey.

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

Dark matter is one of the biggest mysteries of the Universe. Its properties cannot be explained with the known laws of physics and elementary particles.

This thesis discusses several questions regarding the double ramification cycle as a Chow class on the moduli space of stable n-pointed genus g curves using tools from so-called logarithmic geometry.

Promotor: Prof.dr. G.P. van Wezel

Promotor: P.D. Grünwald

Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

The increasing competition in the automotive industry requires the tailored, swift development of technologically sophisticated vehicles. Therefore, the computationally expensive state-of-the-art simulation technologies are combined with optimization algorithms. An example of a real-world optimization…

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

Promotor: Prof.dr. S.F. Portegies Zwart

In this Yearbook you will find some fascinating examples of what was done in 2021, not only by ourselves, but also by our international colleagues.

Dit proefschrift onderzoekt de noodzaak van het creatief denken en experimenteren in het uitvoeren van complexe muziek in de late twintigste- en vroege eenentwintigste eeuw.

Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros

Three major cosmology-focused missions are planned for the next decade: the Euclid space telescope, the Vera C. Rubin Observatory in Chile, and the Nancy Grace Roman Space Telescope.

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…

Outflows are crucially important for the gas budget and evolution of luminous star-forming galaxies and AGNs, with observed mass outflow rates of the same order as the star formation rate. Greater star formation and black hole growth lead to more intense feedback and outflows, resulting in self-regulated…

Vast, often populated, areas in dryland ecosystems face the dangers of desertification.

The Copenhagen interpretation of quantum mechanics states that a measurement collapses a wavefunction onto an eigenstate of the corresponding measurement operator.

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

Supervisor: P.J.J. Hooykaas

Promotor: Prof.dr. H.J.A. Rottgering

Balsaminaceae is a diverse plant family characterized by a huge floral morphological diversity.

We have conducted a full spectral line survey of the 3-13 micron region of two massive protostars, AFGL 2591 and AFGL 2136, for the first time at high spectral resolution.

Promotor: J.N. Kok, Co-promotor: C.M. Soares, A.J. Knobbe

Protein–protein complexes are formed via transient states called encounter complexes that greatly influence the formation of the stereospecific complex.

More than 5,000 exoplanets have been found over the past couple of decades. These exoplanets show a tremendous diversity, ranging from scorching hot Jupiters, common super-Earths, to widely separated super-Jupiters on the planet/brown dwarf boundary.

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Promotor: J. Aarts

Promotor: Thomas Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto

The different kinds of cultural perspectives on health and disease of the participants are related to their knowledge, beliefs, values and practices manifested in various forms of lifestyle in Indonesia. The cultural diversity of the population is also related to differences in health behaviour.

Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.

This thesis discusses the physical and chemical processes than influence the composition of forming planets.

Special Issue in: Visual Anthropology, Volume 29, Issue 3, 2016

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

Majorana fermions in superconductors are the subgap quasiparticle excitations that are their own antiparticles.

In dit vierde rapport worden ontwikkelingen besproken ten aanzien van het beleid met betrekking tot personen die terugkeren uit jihadistische strijdgebieden, zogeheten ‘terugkeerders’, voor de periode januari 2017 tot medio december 2018.

Promotor: Bas Edixhoven, Promotor: Qing Liu

Promotores: Prof.dr. G. Miley & Prof.dr. J.M. van den Broek

In this thesis, we develop a novel technique called Optical Near-field Electron Microscopy (ONEM), which aims to combine the advantages of both optical and electron microscopy: the high resolution of electron microscopy and the low sample damage of optical microscopy.

Promotor: Prof.dr. G.R. de Snoo, Co-promotor: R. Heijungs

The Standard Model (SM) of particle physics fails to explain several observed phenomena and is incomplete. In order to resolve this problem, one may extend the SM by adding new particles.

Promotores: P.G.L. Klinkhamer, P.M. Brakefield, Co-Promotor: M. Bruinsma

This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.