As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

Promotores: T.H.W. Bäck, Y. Tan, Co-promotor: M.T.M. Emmerich

Carbohydrates, or sugars, are the most diverse and most abundant biomolecules known. However, the isolation of carbohydrate samples in sufficient amounts and purity is often impractical or even impossible, so the chemical synthesis of glycosides becomes relevant. The glycosylation reaction, in which…

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Natural resources often stretch across borders that separate modern nation states. This can create conflict and limit opportunities for regulated consumption of their goods and services, but also provide opportunities for joint multinational efforts that exceed single country capabilities.

The development of new environmentally sound technologies is seen as a key route towards achieving sustainability.

Promotor: K.J. Batenburg, Co-promotor: A.W. van der Vaart, B. de Smit

Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)

Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.

Kidney transplantation is a major advance of modern medicine. This course will give you state of the art updates about what used to be an experimental, risky, and very limited treatment option more than 50 years ago and is now routinely performed in many countries worldwide.

Reconstructie van de taalgeschiedenis en prehistorie in de context van de Indo-Europese taalfamilie.

Studievoorlichting

Explore "Surgical anatomy of the leg in relation to nerve injuries" at Boerhaave Nascholing. Read more here.

Studievoorlichting

During the summer, we organize a summer school for researchers who want to learn about communicating science to diverse audiences. The summer school is aimed at researchers in any career stage who are new to science communication. The Summer School is open for all disciplines in science, including social…

Public Administration is a major refereed journal publishing articles on public administration, public policy and public management.

What are the pressing issues of our time, and how can different disciplines come together to address them? Studium Generale and Leiden University College (LUC) present the Global Challenges series: events that bring together researchers from LUC and experts from other disciplines to tackle a shared…

The findings in this thesis improve the understanding of 1) the relationship between exposure characteristics and toxicity of ENPs, 2) the joint toxic action of ENP mixtures and the comparison to metal salt mixtures, 3) how NOM affects the individual and joint toxicity of ENPs, 4) the extent of trophic…

Dit boek neemt je stapsgewijs mee in het schrijven van een scriptie, met (voornamelijk) een focus op experimenteel onderzoek, dat het meest veel voorkomt. Door de stappen van experimenteel onderzoek in chronologische volgorde op te splitsen en bij elke stap tips te geven, hopen de auteurs enig houvast…

Discover the master program population Health Management at Leiden University and contribute to a more integrated health care system. Learn more!

Promotor: Prof.dr. M. Schilthuizen

Promotores: H.W. Lenstra, K. Belabas (University of Bordeaux)

Promotores: J. Kok, M. Chaudron (Chalmers University)

This dissertation explores how we can make anomaly detection—identifying unusual or faulty behavior in complex systems—more trustworthy and effective, with a focus on smart manufacturing.

In recent decades, climate change has led to more frequent and severe drought events, causing serious consequences such as increased forest mortality and significant crop yield losses. Understanding how drought affects plants, especially economically important herbaceous species, is crucial for predicting…

Tuberculosis is a major global health problem caused by the Mycobacterium tuberculosis complex, claiming more than a million lives annually.

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

Hydrogen peroxide (H2O2) is an important bulk chemical that is used in various industrial processes. More than 95% of the H2O2 used in industry is made via the anthraquinone process during which a large amount of energy is going to waste.

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

Promotor: F.J. van Lunteren, E. Jorin

Studievoorlichting

Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).

Hieronder vind je de antwoorden op een aantal veelgestelde vragen over toelating tot de klinische specialisaties van de Master Psychologie.

Promotie

Students Practicing Citizen Journalism

Computational thinking, programming, and algorithms form the basic of many of the things that are shaping our world, the way we work, interact, organize ourselves, and even spend our free time with social networks, streaming media, and games. And this transformation is far from being complete, it is…

The class-imbalance problem is a challenging classification task and is frequently encountered in real-world applications. Various techniques have been developed to improve the imbalanced classification performance theoretically and practically.

Het Nederlands-Vlaams Instituut in Cairo (NVIC) is in 1971 opgericht. Negen universiteiten in Nederland en Vlaanderen participeren in het NVIC met als doel het stimuleren en internationaliseren van hun onderwijs- en onderzoeksactiviteiten in het Midden-Oosten. De beheervoerende instelling is de Universiteit…

Oude historici zijn zich al lange tijd bewust dat patronen in de circulatie van munten licht kunnen werpen op de mate van economische integratie in het Romeinse Rijk. Meer dan veertig jaar geleden stelde Hopkins dat grote hoeveelheden belastinggeld werden uitgegeven in de grensprovincies en dat de niet-militaire…

Promotores: C.A.M.J.J. van den Hondel, V. Meyer, Co-promotor: A.F.J. Ram

Promotor: Robert Tijdeman, Co-promotor: Cornelis Kraaikamp

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Alumni-activiteit

How can we broaden youth participation in STEM Learning

Corruption, integrity (or a lack thereof…) and public values are near omnipresent elements in public administration and politics of all times. Cases of corrupt public officials and politicians continuously emerge. Strangely enough, however, it often remains unknown what actually occurred, how something…