Toll-like receptors (TLRs) are central components of the innate immune system, functioning as pattern recognition receptors that detect microbial- and damage-associated molecular patterns and initiate antimicrobial and inflammatory responses.

Promotie

Promotor: Prof.dr. E. Eliel, Co-Promotor: M.J.A. de Dood

This work is dedicated to interpreting in cohomological terms the special values of zeta functions of arithmetic schemes.

Mycorrhizas are symbiotic associations between soil fungi and most plant species.

Promotor: M. Franx, Co-Promotor: I.F. Labbé

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

Een lijst met wetenschappelijke publicaties samengesteld door het team van het TRIXY Expertisecentrum.

Promotor: Prof.dr. K.H. Kuijken, Co-Promotor: H.Hoekstra

In this thesis, deep learning is studied from a statistical perspective. Convergence rates for the worst case risk bounds of neural network estimators are obtained in the classification, density estimation and linear regression model.

A modern ship design process is subject to a wide variety of constraints such as safety constraints, regulations, and physical constraints.

Promotor: Prof.dr. D. Bouwmeester

Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?

Op 7 november 2018 verdedigde Catherine Harwood haar proefschrift 'Navigating Between Principle and Pragmatism: The Roles and Functions of Atrocity-Related United Nations Commissions of Inquiry in the International Legal Order'. Het promotieonderzoek is begeleid door promotoren prof. dr. L.J. Van den…

In dit interdisciplinaire onderzoeksprogramma werken onderzoekers uit vijf verschillende disciplines met elkaar samen. Zij stellen zich hieronder (in het Engels) aan u voor.

In this thesis three different topics in number theory are studied.

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

Hoe kunnen praktijk en theorie elkaar versterken in de neurowetenschappen? Hoogleraar Birte Forstmann spreekt in haar oratie op 2 oktober over het bouwen van interdisciplinaire bruggen tussen cognitieve neurowetenschap en cognitieve modellen. Haar aanpak kan bijdragen aan hersenonderzoek met minder…

Continuous optimization is never easy: the exact solution is always a luxury demand and the theory of it is not always analytical and elegant.

Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri

Hoe meer we leren over een (neuro-)psychologische of lichamelijke aandoening en de hieraan gerelateerde gedragsfactoren, hoe beter we deze niet alleen kunnen signaleren, maar ook behandelen. Het is dus belangrijk dat recente inzichten over (neuro-)psychologische problemen en daaraan gerelateerde gedragsfactoren…

Hersenstimulatie en voedingssupplementen zoals tyrosine of tryptofaan lijken veelbelovende opties om de cognitieve prestaties te verbeteren. Dat constateert psycholoog Laura Steenbergen. Maar ze stelt ook dat er meer onderzoek nodig is. Promotie op 16 juni.

The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.

Hoe kunnen mensen hun prestaties verbeteren en hun creatieve potentieel benutten? Dat is het onderwerp van het nieuwe Journal of Cognitive Enhancement. Dit interdisciplinaire wetenschappelijke tijdschrift is een initiatief van de Leidse psycholoog Lorenza Colzato. Eerste publicatie maart 2017.

De sectie Cognitieve Psychologie draagt bij aan de 3-jarige bacheloropleiding en verzorgt 2 masterspecialisaties.

De Iraakse archeologische site Nimrud werd kort geleden terugveroverd op IS. Maar wat nu te doen met de beschadigde resten? Bleda Düring sprak erover in Trouw.

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

This thesis describes the role of pollution, specifically neonicotinoid insecticides, as an actor of the ongoing biodiversity decline.

Optimally solving real-world expensive Black-Box Optimization (BBO) problems w.r.t. real-world constraints, such as wall-clock time and computational costs, is extremely difficult and tedious.

Promotor: Prof.dr. A.W. van der Vaart

Every day, the intestines face an enormous challenge. They must absorb nutrients, medicines, and other substances we consume, while keeping harmful compounds out.

Faciliteiten waar LIBC leden gebruik van kunnen maken (in het Engels):

In this thesis we use state-of-the-art observations and simulations to provide the best constraints to date on the HVS ejection rate and constraints on the stellar content and dynamics at the GC, including the progenitor binary populations and their star formation history.

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

This thesis consists of two main parts. The first part (Chapters 2 and 3) deals with a class of Markov process called Quasi-Skipfree (QSF) processes.

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Promotor: A.P. IJzerman

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

This work describes several studies into the electroreduction of carbon dioxide (CO2RR), both regarding mechanistical aspects and catalyst stability considerations. Mechanistic insights into carbon-carbon bond formation on a silver catalyst are described in Ch 2, were we find an acetaldehyde-like surface…

Aangezien jeuk en pijn zeer belastend kunnen zijn, vooral wanneer mensen chronisch aan (een van) deze symptomen lijden, is het belangrijk te weten door welke factoren deze gewaarwordingen worden beïnvloed. Het wordt steeds duidelijker dat psychologische factoren een belangrijke rol spelen bij het ervaren…

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.