Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Constraint multi-objective optimization with a limited budget for function evaluations is challenging. This thesis tackles this problem by proposing new optimization algorithms. These algorithms are applied on holistic ship design problems. This helps naval architects balance objectives like cost, efficiency,…

The thesis describes the development, synthesis and biological evaluation of several proteasome inhibitor designs. Mainly, this work focusses on designing proteasome inhibitors that selectively inhibit the immunoproteasome, while leaving the constitutive proteasome mostly, if not completely, untouch…

Onderzoeken en ontwerpen zijn twee vaardigheden die steeds belangrijker worden in de vakken O&O (onderzoeken en ontwerpen) en NLT (natuur, leven en technologie). Uit onderzoek van Tessa Vossen (ICLON en Faculteit Wiskunde en Natuurwetenschappen) blijkt dat docenten en leerlingen de relevantie van onderzoeken…

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

Een pilletje op een festival, een biertje in de kroeg, of een sigaret bij de koffie. We wéten dat het slecht voor ons is, maar doen het toch. Hoe komt dat?

The increasing competition in the automotive industry requires the tailored, swift development of technologically sophisticated vehicles. Therefore, the computationally expensive state-of-the-art simulation technologies are combined with optimization algorithms. An example of a real-world optimization…

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich

In design optimization problems, engineers typically handcraft design representations based on personal expertise, which leaves a fingerprint of the user experience in the optimization data. Thus, learning this notion of experience as transferrable design features has potential to improve the performance…

Microscopic insight on lipid-based nanomedicine in vivo remains limited to the perception of the knowledge that could be obtained: if we interpret only what we see, then we only believe to know. Although believing to know encapsulates an undefined amount of uncertainty in the exploration of lipid-based…

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.

Promotor: A.P.IJzerman Co-promotor: A. Bender

Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…

We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

Promotor: B. van de Water

Promotores: Prof.dr. G. Miley & Prof.dr. J.M. van den Broek

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Promotores: C.A.J. Knibbe; J.N. van den Anker, Co-promotores: H.P.A. van Dongen; B. van Ramshorst

Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …

The path to rational drug and dose selection

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

Promotie

Promotie

The project seeks to develop an eco-design framework for single-use medical devices and packaging

Electoral Systems and Turnout: Evidence From a Regression Discontinuity Design. In dit artikel, gepubliceerd op de website SAGE research methods, bespreken auteurs Jaroslaw Kantorowicz en Tobias M. Hlobil hoe een Regression Discontinuity Design uitgevoerd kan worden.

Wat is een goede wetgeving inzake gegevensbescherming? Hoe kan een dergelijke wetgeving goed worden ontwikkeld? Is de Europese wetgeving hierover adequaat, en is deze toepasbaar in China?

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

Promotor: Prof.dr. H.A.G. Wijshoff

Promovenda Luisa Prochazkova deed samen met haar collega's van cognitieve psychologie onderzoek naar de effecten van microdoseringen psychedelische drugs op creativiteit. Hun eerste voorzichtige conclusie: je wordt inderdaad creatiever van een klein beetje LSD.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

In welke mate zijn beoordelingen op basis van een videodossier betrouwbaar, generaliseerbaar en valide?

Technologies that help to enhance our educational environments can be found everywhere.

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

Plants and their pollinators form complex interaction networks. Within these networks, species differ widely in the number of species they interact with.

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

Promotor: Prof.dr. M. Ubbink, Co-promotor: G. Siegal