Climate change is one of the largest challenges faced by humanity. To combat this research into alternatives to fossil fuels is ongoing. Dihydrogen is considered a good alternative fuel, since its burning only forms water.

Solar energy harnessed by plants and algae has great potential to be converted into biofuels for future generations.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Inspired by natural photosynthesis, perovskite-based photoelectrochemical (PEC) systems are being developed for artificial photosynthesis, aiming to enhance solar-to-hydrogen conversion for green energy.

This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.

This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.

Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.

A dense region of a gaseous and dusty cloud collapses to form a protostar surrounded by a disk and an envelope. This thesis uses both observations and models to study physical and chemical conditions of these protostellar systems which are likely where planets start to form.

Promotor: J. Schaye

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.

Microbial rhodopsins are photosensitive pigments implemented in the growth and adaptation of a large population of microorganisms.

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)

Understanding how nature captures and transfers solar energy is essential both for elucidating biological photosynthesis and for guiding the design of artificial light-harvesting systems.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

With the rise of multi-drug resistant bacterial pathogens, the possibility of a post-antibiotic world is quickly becoming reality.

To address the fundamental questions of how life on Earth emerged and how common life may be in the Universe, it is crucial to know the chemical composition of the planet-forming material.

Promotor: J.W.M. Frenken Co-Promotores: I.M.N. Groot; L.B.F. Juurlink

This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Promotor: H.J.M. de Groot

Cyclic peptides are investigated as a platform to induce different orientations between various ligands.

Onderwijsminister Jet Bussemaker kreeg op de Dag van de Excellentie op 20 juni een exemplaar van ‘Chemistry in Conflict’, een educatief boek over de rol van chemie in oorlogsvoering. Ludo Juurlink, directeur van het Junior Science Lab, overhandigde het boek.

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

Binnen het Graduate Programme van Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) is de aanvraag voor de 'Netherlands Magnetic Resonance Research School' gehonoreerd. Deze onderzoeksschool is een van de 18 gehonoreerde aanvragen. Vier Leidse Graduate Schools zijn gehonoreerd.

Op woensdagavond 24 mei was Huub de Groot te horen in het programma Science071, het Leidse wetenschapsprogramma van Sleutelstad FM. Hij werd zo'n 15 minuten ondervraagd over het onderwerp van zijn onderzoek naar het omzetten van CO2 naar brandstof.

Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

The research described in this thesis focused on the preparation of S/N functionalized carbene ligands and their transition metal complexes, and the exploration of their application as electrocatalysts for proton reduction.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

Pseudomonas Aeruginosa is a Gram-negative bacterium which can form biofilms, increasing its resistance against antibiotics and the host immune system. Polysaccharides are an integral part of this biofilm, one of these polysaccharides is called Psl. PslG is a glycosidase, able to cleave this polysaccharide,…

In het novembernummer van C2W werd Remco geinterviewd en vertelt hij over zijn twee passies, onderzoek en films produceren.

Promotor: H.V.J. Linnartz

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.

Voor de oktoberissue van het alumnimagazine Leidraad van de Universiteit Leiden werd Huub de Groot geinterviewd in het kader van het Europese SUNRISE consortium.

Wetenschappers zijn druk bezig zonne-energie vast te leggen in CO2-neutrale ‘solar fuels’. Dat klinkt veelbelovend, maar er is ook kritiek. Zijn die brandstoffen wel echt wel CO2-neutraal en maakt concurrentie door alternatieven ze niet overbodig?

Artikel in het Alumni magazine 'Leidraad', Winter 2015 met als onderwerp 'feit of fictie' waarin de vrijheid van onderzoekers door de eisen van politiek, maatschappij, universiteit en bedrijfsleven bevraagd wordt. Interview met Huub de Groot.

Prof. Huub de Groot vertelde dinsdag 21 april 2015 over de mogelijkheden van duurzame waterstof bij de opening van de waterstofgenerator bedoeld als tankstation voor de busjes van Stadsparkeerplan aan de Leidse Haagweg.