The plant hormone auxin plays a central role in the growth and development of plants. Auxin acts in a concentration dependent manner and polar cell-to-cell transport of this hormone determines its distribution in the tissues of plants. This polar auxin transport is mediated by several families of auxin…

In my research, I used a comparative wood anatomical approach to address wood evolution of the (largely) tropical flowering plant families Apocynaceae and Sapotaceae.

Promotor: R. Gill, Co-promotor: P. Massart

Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

Food waste is a defining inefficiency of the modern food system, with profound implications for resource use, climate change, and circular economy transitions. This dissertation examines food waste through two complementary lenses: the prevention of avoidable food waste and the valorization of unavoidable…

In this thesis we classify the pairs (p,G), where p is a prime number and G is a finite p-group possessing an intense automorphism, i.e. an automorphism that sends each subgroup of G to a G-conjugate, that is non-trivial and whose order is coprime to p.

Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

We have conducted a full spectral line survey of the 3-13 micron region of two massive protostars, AFGL 2591 and AFGL 2136, for the first time at high spectral resolution.

Promotores: P.G.L. Klinkhamer, P.M. Brakefield, Co-Promotor: M. Bruinsma

Supervisor: P.J.J. Hooykaas

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

Oude historici zijn zich al lange tijd bewust dat patronen in de circulatie van munten licht kunnen werpen op de mate van economische integratie in het Romeinse Rijk.

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

Environmental challenges such as plastic pollution and biodiversity loss require extensive monitoring. Citizen science, in which members of the public participate in scientific research, has therefore become an important approach in environmental science.

Promotie

Promotie

Op 8 juli 2020 verdedigde Andres Sarmiento Lamus zijn proefschrift 'The Proliferation of Dissenting Opinions in International Law'. Het promotieonderzoek is begeleid door promotoren prof.dr. L.J. van den Herik en prof.dr. Y.A.A.S. Radi (UCLouvain).

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

Dynamical systems describe the evolution of objects in a space over time and may be used to model physical phenomena. Due to this, much research is dedicated to understanding the mathematics of dynamical systems.

In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

This dissertation presents a new perspective on the life, work and character of the Dutch physical chemist Jacobus Henricus van ’t Hoff, first recipient of the Nobel Prize in Chemistry, and one of the most important and colourful scientists in Dutch history. The image of Van ’t Hoff that emerges from…

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

Artin L-functions associated to continuous representations of the absolute Galois group G_K of a global field K capture a lot of information about G_K as well as arithmetic properties of K.

Microglia support the central and peripheral nervous system by forming the first line of defense against hazardous events. Microglia are increasingly acknowledged as critical players in neurodegenerative diseases, highlighting them as potential therapeutic targets.

Multi-objective evolutionary computation aims to find high quality (Pareto optimal) solutions that represent the trade-off between multiple objectives.

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

The origin and evolution of galaxies are closely tied to the cyclic feedback processes between stars and the interstellar medium (ISM).

Op 11 juni 2020 verdedigde Sabine Witting haar proefschrift 'Child Sexual Abuse in the Digital Era: Rethinking Legal Frameworks and Transnational Law Enforcement Collaboration'. Het promotieonderzoek is begeleid door promotoren prof.mr. J.J. Sloth-Nielsen en prof.dr.mr. S. van der Hof.

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Announcement of a new publication by Janneke Verheijen, lecturer at the Institute of Cultural Anthropology and Development Sociology.

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Op 16 juni 2020 verdedigde Andrea Varga haar proefschrift 'Establishing State Responsibility in the Absence of Effective Government'. Het promotieonderzoek is begeleid door promotoren prof. dr. N.J. Schrijver en prof. dr. F. Baetens (University of Oslo).

Promotor: Prof.dr. E. Bouwman, Co-Promotor: S. Bonnet

It is an established fact that the Standard Model has to be extended to explain the so-called Beyond the Standard Model (BSM) phenomena: dark matter, matter-antimatter asymmetry of the Universe and neutrino flavour oscillations.

Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Homohuwelijk, draagmoederschap, abortus. Hoe reageert het recht op dergelijke moreelgevoelige onderwerpen bij grensoverschrijdend verkeer binnen de Europese Unie? Op 4 november 2015 promoveert Nelleke Koffeman op dit onderwerp.

Promotor: P.M. Brakefield

We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…

The research in this dissertation aims to optimise blood donation processes in the framework of the Dutch national blood bank Sanquin. The primary health risk for blood donors is iron deficiency, which is evaluated based on donors' hemoglobin and ferritin levels.

A recent study on reintroduced tigers in Panna Tiger Reserve in India reveals that risks from tigers increased more because of human behaviour and people's livestock husbandry practices.

Did the Jochids leave their mark on the Grand Duchy, taking into account that the Lithuanian state was one of the main successor states of the Great Horde in the 16thCentury?

In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

Seagrass is a marine flowering plant with special adaptations to coastal and marine environments, playing a crucial role in providing a wide range of ecosystem services.

The Sundanese people, the largest ethnic group in West Java, have been using traditional medicine for a long time. Known as ubar kampung, Sundanese indigenous knowledge, beliefs and practices of traditional medicine are based on local people’s knowledge and use of Medicinal, Aromatic, and Cosmetic (MAC)…

Van Mexico en Indonesië tot China en Tsjechië: mensen van over de hele wereld lazen over de publicatie van de Leidse Sterrewacht over de geboorteplaats van kometen. Dit onderzoek suggereert dat alle kometen in ons zonnestelsels mogelijk op dezelfde plek geboren zijn: een bepaalde zone in de platte schijf…

Research

How were the Russians, under early modern conditions, able to incorporate this distant, undeveloped and, because frequent nomadic attacks, dangerous territory? And what role did the Kolyvan-Voskresensk plants play in this process?

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