Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

Lipid nanoparticles (LNPs) have enabled the success of mRNA vaccines but remain limited in broader therapeutic use by challenges in delivery efficiency, targeting, and mechanistic understanding.

Hoe hebben humanitaire organisaties voorbereidings- en responsstrategieën voor cyberincidenten afgestemd op hun specifieke prioriteiten, behoeften en context?

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Tijdens het spelen van online games kunnen conflicten ontstaan. Novin, Bos, Stevenson en Rieffe onderzochten in dit artikel welke factoren maken dat de ene jongere daarbij bozer reageert dan de andere. In hun realistisch nagemaakte spel begon de zogenaamde medespeler plotseling te mopperen dat de deelnemer…

Onderzoek toont aan hoe jongens reageren op bewustwordingstrainingen over intimidatie en waarom ze straatintimidatie vaak niet als 'hun' probleem zien.

Dit artikel onderzoekt de integratie van scenariogebaseerd leren (SBL) in een cursus crisiscommunicatie om de praktische vaardigheden en reflectie van studenten in echte situaties te verbeteren.

Dit artikel geeft een overzicht van de literatuur over de effecten van multilevel governance (MLG) op de beleidsreacties van regeringen op Covid-19.

Promotor: E.F. Smets Co-promotor: J. Geml

Hoe beheren humanitaire responsorganisaties (HRO's) en virtuele en technische gemeenschappen (V&TC's) gezamenlijk de processen voor het bepalen van de betekenis van rampen, en welke uitdagingen vormen de effectiviteit van deze samenwerkingen tussen 2010 en 2016?

In dit artikel onderzoeken Seda Gürkan, Özlem Atikcan en George Christou hoe de EU-instellingen hebben gereageerd op de democratische achteruitgang in Turkije tussen 2014 en 2024. Ze analyseren hoe de Europese Commissie, het Europees Parlement en de Europese Raad de voorwaarden hebben geformuleerd en…

Vaak wordt gezegd dat een crisis iemands ware aard naar boven brengt. Het coronavirus stelt het multilaterale systeem op de proef. Politicoloog Gisela Hirschmann (Universiteit Leiden) maakt zich zorgen over de toekomst van internationale samenwerking.

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Promotores: J. Jonkers, K.E. de Visser

Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

Toll-like receptors (TLRs) are central components of the innate immune system, functioning as pattern recognition receptors that detect microbial- and damage-associated molecular patterns and initiate antimicrobial and inflammatory responses.

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

Promotor: W. Jiskoot, Co-promotor: A. Hawe

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Emoties spelen een cruciale rol in de EU-politiek. Dit artikel onderzoekt hoe emoties de EU-reactie op internationale crises door normovertredingen beïnvloeden.

In dit artikel onderzoeken Layla van Wieringen, Daan Weggemans en Marieke Liem hoe rechts-extremistische ouders de ideologische socialisatie van hun kinderen bespreken en rechtvaardigen.

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

This thesis investigates a pharmacological challenge model induced by Toll-like receptor 7 (TLR7) activation, focusing on skin inflammation and its implications for early drug development.

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

Promotor: B. van de Water

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

In this thesis, single-cell approaches were applied to characterize the impact of aging on the immunological B cell landscape in different models of atherosclerotic cardiovascular disease, with the goal to identify and study new B cell-associated biomarkers and therapeutic targets to halt atherosclerosis…

Promotores: Wim Jiskoot; Ferry Ossendorp

Healthy aging is one of the prime goals in today's society and atherosclerosis is among the greatest causes of morbidity in elderly. Cardiovascular disease patients receiving treatment are often of advanced aged and have an aged immune system, which limits translating experimental findings to the pa…

Advanced UHF MRI techniques provide powerful tools for studying the zebrafish brain, an emerging model in neurological research. In this work, various MRI and localized MRS methods are optimized and employed for UHF strength for studying the zebrafish brain.

Control of infectious diseases poses continuous challenges for human health.

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. M. van der Zee

Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager

This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

Promotor: B.van de Water, Co-promotor: L.S.Price

Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.

Ongewenste associaties met seks kunnen afgeleerd worden, maar terugkeren als de omstandigheden veranderen. Daarom moet het afleren in diverse situaties plaatsvinden. Het geneesmiddel D-cycloserine biedt mogelijk uitkomst. Dat ontdekte psychologe Mirte Brom.

Promotie

Despite substantial progress in understanding tuberculosis (TB), the eradication of the TB epidemic is still far from reach.

Promotie

Exploring metabolomics-based biomarkers for diagnosis and treatment response monitoring of community-acquired pneumonia

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…