In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.

Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

Humans can see the world through the eyes of other humans and imagine what they know, want, and intend. This competence is known as Theory of Mind.

The ability to count is a property not often attributed to materials, despite the abundance of memory in materials. Regardless of how a material stores information, it is often difficult to retrieve exactly ‘what’ a material remembers.

All crested and marbled newts (the genus Triturus) suffer from an unusual genetic abnormality, called a balanced lethal system, that kills exactly half of their offspring. How can a trait so disadvantageous have survived millions of years of natural selection?

Galaxies are environments where gas coalesces, cools, and is converted into stars. However, it remains unclear the exact mechanisms through which galaxies acquire, redistribute and lose their gas.

Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.

The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.

This thesis discusses the physical and chemical processes than influence the composition of forming planets.

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

Promotores: E. van Dijk, G.R. de Snoo. Co-promotor: H. Staats

Promotor: J. N. Kok, Co-promotor: A. J. Knobbe

This dissertation presents the synthesis and evaluation of antibody recognition for various capsular polysaccharide (CP) fragments of Staphylococcus aureus (S. aureus).

To contribute to the body of knowledge aiming at a better coverage of ecosystem service assessment in LCA studies, this thesis dives into the challenges of incorporating existing ecosystem service methods within the impact assessment phase of the conventional LCA framework.

When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).

In astronomy, the interpration of observations and measurements plays a crucial role: we rely purely and fundamentally on the information that reaches us as observers. And 80% of all matter in the universe is undetectable directly.

If X is a locally compact Hausdorff space, then a representation of the complex C* algebra C_0(X) on a Hilbert space $H$ is given by a spectral measure that takes its values in the orthogonal projections on $H$.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

This thesis deals with properties of Jacobians of genus two curves that cover elliptic curves.

Promotor: J.W.M. Frenken

Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.

This dissertation presents new cryptographic protocols, which can be divided into two families.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.

The physical origin of the dozens of stellar-mass binaries, the mergers of which have been detected by the LIGO-Virgo-KAGRA collaboration via gravitational waves, is still unknown.

Wetlands provide many ecosystem goods and services which include fish production. The sustainability of small-scale fisheries (SSF) has received considerable attention in recent years because fish is one of the major sources of animal protein to a considerable fraction of the global population which…

Promotor: B. van de Water

In this dissertation, matching, entropy, holes and expansions come together. The first chapter is an introduction to ergodic theory and dynamical systems.

Promoter: Ed F. Deprettere, Co-promoter: Todor P. Stefanov

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

Students Practicing Citizen Journalism

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)

Promotores: T.H. Oosterkamp, N. de Jonge

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

With the advent of multicore processors and data centers, computer hardware has become increasingly parallel, allowing one to run multiple pieces of software at the same time on different machines. Coordination of these pieces is best expressed in a coordination language as an explicit interaction protocol…

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

In this thesis we study bistable reaction-diffusion equations on lattice domains.

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Promotor: W. T. F. den Hollander, F. H. J. Redig

Promotor: K.J. Batenburg

This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…

Promotor: Prof.dr. A.W. van der Vaart

Promotor: Prof.dr. S.F. Portegies Zwart

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

Technologies that help to enhance our educational environments can be found everywhere.