Bulgarije kwam relatief ongeschonden uit de eerste golf, maar in het najaar van 2020 namen het aantal infecties, ziekenhuisopnames en sterfgevallen sterk toe. Dit onderzoek analyseert hoe de Bulgaarse regering op de Covid-19 pandemie heeft gereageerd.

Stemwijzers—applicaties die kiezers helpen te bepalen welke partij of kandidaat het beste past bij hun politieke voorkeur—spelen een steeds belangrijker rol in verkiezingen. De politicologen Martin Rosema (Universeit Twente) en Tom Louwerse (Universiteit Leiden) onderzoeken of het ontwerp van deze publicaties…

Op12 promoveert Alice Ross T. Morta. Het Leiden University Centre for Linguistics feliciteert Alice!

Promotie

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Advanced UHF MRI techniques provide powerful tools for studying the zebrafish brain, an emerging model in neurological research. In this work, various MRI and localized MRS methods are optimized and employed for UHF strength for studying the zebrafish brain.

In this thesis, single-cell approaches were applied to characterize the impact of aging on the immunological B cell landscape in different models of atherosclerotic cardiovascular disease, with the goal to identify and study new B cell-associated biomarkers and therapeutic targets to halt atherosclerosis…

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. M. van der Zee

Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.

Control of infectious diseases poses continuous challenges for human health.

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

Hoe hebben humanitaire organisaties voorbereidings- en responsstrategieën voor cyberincidenten afgestemd op hun specifieke prioriteiten, behoeften en context?

Tijdens het spelen van online games kunnen conflicten ontstaan. Novin, Bos, Stevenson en Rieffe onderzochten in dit artikel welke factoren maken dat de ene jongere daarbij bozer reageert dan de andere. In hun realistisch nagemaakte spel begon de zogenaamde medespeler plotseling te mopperen dat de deelnemer…

Onderzoek toont aan hoe jongens reageren op bewustwordingstrainingen over intimidatie en waarom ze straatintimidatie vaak niet als 'hun' probleem zien.

Dit artikel onderzoekt de integratie van scenariogebaseerd leren (SBL) in een cursus crisiscommunicatie om de praktische vaardigheden en reflectie van studenten in echte situaties te verbeteren.

Dit artikel geeft een overzicht van de literatuur over de effecten van multilevel governance (MLG) op de beleidsreacties van regeringen op Covid-19.

Hoe beheren humanitaire responsorganisaties (HRO's) en virtuele en technische gemeenschappen (V&TC's) gezamenlijk de processen voor het bepalen van de betekenis van rampen, en welke uitdagingen vormen de effectiviteit van deze samenwerkingen tussen 2010 en 2016?

Vaak wordt gezegd dat een crisis iemands ware aard naar boven brengt. Het coronavirus stelt het multilaterale systeem op de proef. Politicoloog Gisela Hirschmann (Universiteit Leiden) maakt zich zorgen over de toekomst van internationale samenwerking.

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

Understanding how galaxies form, interact, and evolve comes largely from comparing theory predictions with observational data. Numerical simulations of galaxies provide the most accurate approach to testing the theory, as they follow the non-linear evolution of gas and dark matter in great detail and…

Promotores: Wim Jiskoot; Ferry Ossendorp

Healthy aging is one of the prime goals in today's society and atherosclerosis is among the greatest causes of morbidity in elderly. Cardiovascular disease patients receiving treatment are often of advanced aged and have an aged immune system, which limits translating experimental findings to the pa…

Promotor: B.van de Water, Co-promotor: L.S.Price

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

Promotores: A.H. Meijer, H.P. Spaink

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Emoties spelen een cruciale rol in de EU-politiek. Dit artikel onderzoekt hoe emoties de EU-reactie op internationale crises door normovertredingen beïnvloeden.

Promotie

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

This thesis investigates a pharmacological challenge model induced by Toll-like receptor 7 (TLR7) activation, focusing on skin inflammation and its implications for early drug development.

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).

Deelproject van “

Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius

Promotor: P.M. Brakefield

Promotor: B. van de Water

Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver