288 zoekresultaten voor “building” in de Publieke website
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Towards near-infrared light-activated combination chemotherapy
The goal of the research presented in this thesis was to explore the chemical space of ruthenium(II) photocages, investigate their ability to host potent chemotherapy drugs, and to red shift the activation wavelength of the most promising PACT candidates to conduct biological studies.
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Disrupting the transcriptional machinery to combat triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.
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Hydrodynamics and the quantum butterfly effect in Black Holes and large N quantum field theories
Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?
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Inhibitors and activity-based probes for β-D-glucuronidases, heparanases and β-L-arabinofuranosidases
Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.
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Low-temperature spectroscopic studies of single molecules in 3-D and on 2-D hosts
Spectroscopic studies on fluorescent single molecules in organic condensed matter does not only provide information about the molecule itself, but also its near environment. By suppression of phonon-induced broadening of spectral lines through cooling to low temperatures, small changes in the spectral…
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Rationally designed peptide based functional biomaterials
Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros
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Insights from scanning tunneling microscopy experiments into correlated electron systems
This thesis presents insights from our study of various correlated electron systems with a scanning tunneling microscope (STM). In ordinary metals, electron-electron interactions exist, but get substantially screened due to the sheer number of electrons.
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Synthetic carbohydrate ligands for immune receptors
One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.
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Inextricable ties between chemical complexity and dynamics of embedded protostellar regions
Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh
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Systemic Accountability of the European Border and Coast Guard
Op 11 november 2021 verdedigde Mariana Gkliati het proefschrift 'Systemic Accountability of the European Border and Coast Guard'. Het promotieonderzoek is begeleid door promotoren prof.dr. P. Rodrigues en prof.dr. L. Besselink (UvA).
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SAILS Lunch Time Seminar: Qinyu Chen
Lezing
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Colloidal mechanical metamaterials
This thesis describes how to scale down concepts of macroscopic mechanical metamaterials to the thermal scale using a system of flexibly-linked colloids.
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Individualization of Drug Clearance Predictions and Dose Regimens in Patients with Obesity Using Pharmacometric Approaches
This thesis aims to develop model-based approaches to optimize drug dosing in patients with overweight and (morbid) obesity.
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The opportunities for urban food self-sufficiency through green roofs: Modeling, Optimization, and Policy Scenario Analysis
Conventional food supplies procured from rural areas are increasingly vulnerable to disruptions caused by extreme weather, geopolitical instability, and logistical bottlenecks.
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From Inference to Influence: Applying Causal Game Theory to Complex Security Environments
Effective policy-making requires understanding what truly causes a problem. Only then can policymakers develop targeted interventions that achieve desired outcomes.
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Irene Vikatoue.vikatou@arch.leidenuniv.nl | 071 5272727
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Going global to local: achieving agri-food sustainability from a spatially explicit input-output analysis perspective
The global agri-food system plays a critical role in food security and environmental issues.
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Synthesis of phosphodiester-containing bacterial cell wall components: teichoic acids, capsular polysaccharides and phosphatidyl glycerol analogues
Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée
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Student projects
To get an idea of the science communication products and research that is possible, a few examples of student projects of recent years are shown below.
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Prediction of spatial-temporal brain drug distribution with a novel mathematical model
A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.
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Centre for Digital Humanities
Het Leiden University Centre for Digital Humanities (LUCDH) is een interdisciplinair centrum dat studenten en medewerkers uit de hele Leidse gemeenschap samenbrengt.
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Loopbaanbegeleiding - Master student
Heb jij al nagedacht over wat je wilt doen als je je master aan de Universiteit Leiden hebt afgerond? We helpen je graag op weg.
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Leiden University College The Hague
Leiden University College The Hague (LUC) biedt een 3-jarige bacheloropleiding aan waarin je je focust op Global Challenges; grote uitdagingen waar de mensheid mee te maken heeft: Vrede & Rechtvaardigheid, Diversiteit, Duurzaamheid en Welvaart. Je hebt ruimte om de opleiding zo in te richten als je…
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Trustworthy anomaly detection for smart manufacturing
This dissertation explores how we can make anomaly detection—identifying unusual or faulty behavior in complex systems—more trustworthy and effective, with a focus on smart manufacturing.
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Inhibitors and probes targeting mannanases
This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…
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Structural characterization of bacterial proteins involved in antibiotic resistance and peptidoglycan biosynthesis
This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.
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Mechanical metamaterials: nonlinear beams and excess zero modes
Mechanical metamaterials are man-made materials which derive their unusual properties from their structure rather than their composition.
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Leiden University College The Hague
Leiden University College The Hague (LUC) biedt een 3-jarige bacheloropleiding aan waarin je je focust op Global Challenges; grote uitdagingen waar de mensheid mee te maken heeft: Vrede & Rechtvaardigheid, Diversiteit, Duurzaamheid en Welvaart. Je hebt ruimte om de opleiding zo in te richten als je…
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Reactivity and Selectivity in Glycosylation Reactions
The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.
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Towards High Performance and Efficient Brain Computer Interface Character Speller: Convolutional Neural Network based Methods
A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…
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Quantum computing, norms and polynomials
In this thesis, Quantum computing, norms, and polynomials, we investigate the interplay between quantum mechanics, complexity theory, and functional analysis, three central areas of physics, computer science, and mathematics, respectively.
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Extracurriculaire activiteiten
Haal zoveel mogelijk uit je studie aan de Universiteit Leiden door deel te nemen aan onze extracurriculaire activiteiten.
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Management of Small-Scale Fisheries at the Elephant Marsh in Malawi
Wetlands provide many ecosystem goods and services which include fish production. The sustainability of small-scale fisheries (SSF) has received considerable attention in recent years because fish is one of the major sources of animal protein to a considerable fraction of the global population which…
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Programma
Dit was het programma van De Kennisboomgaard 2025:
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Online Proefstuderen | 13 Oktober 2023
Leiden University College The Hague (LUC) biedt een 3-jarige bacheloropleiding aan waarin je je focust op Global Challenges; grote uitdagingen waar de mensheid mee te maken heeft: Vrede & Rechtvaardigheid, Diversiteit, Duurzaamheid en Welvaart. Je hebt ruimte om de opleiding zo in te richten als je…
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The versatility of asymmetric aminoethyl-tetrazines in bioorthogonal chemistry
This thesis describes the synthesis, analysis of various tetrazine bearing compounds and use in bioorthogonal chemistry.
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Netwerken en community
Het Expertisebureau Diversiteit en Inclusie staat in nauw contact met verschillende studenten- en medewerkersnetwerken op het gebied van diversiteit en inclusie.
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Steden van het Romeinse Nabije Oosten
Het belangrijkste doel van dit onderzoek is om de steden van het Romeinse Nabije Oosten in de keizertijd in kaart te brengen, met een focus op locatie, stadsgrootte en stedelijke kenmerken, om de vorm van het stedelijke systeem en de niveaus van integratie te bestuderen.
- Arsenaal (gerealiseerd)
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Nascholingsdag World Teachers Programme 2024
World Teachers Festival 2024 - Celebrating and exploring language, culture, diversity and criticality in teaching and learning
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C-SCAPE - Sandy strategies for sustainable coastal climate change adaptation
What is the optimal design of sandy solutions for sustainable climate change adaption, from an ecological, biophysical and societal point of view?
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Population-Scale Network Analysis (POPNET)
Een infrastructuur voor onderzoeksdata in computationele sociale wetenschappen
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Online Proefstuderen | 13 Oktober 2023
Leiden University College The Hague (LUC) biedt een 3-jarige bacheloropleiding aan waarin je je focust op Global Challenges; grote uitdagingen waar de mensheid mee te maken heeft: Vrede & Rechtvaardigheid, Diversiteit, Duurzaamheid en Welvaart. Je hebt ruimte om de opleiding zo in te richten als je…
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Bruggen bouwen met LEGO®-stenen: samenwerken over disciplines heen
Hoe kan de methode LEGO® Serious Play® bijdragen aan betere interdisciplinaire samenwerking en het ontwikkelen van gezamenlijke onderzoeksvoorstellen?
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Picturing Scholasticide: The Future of Higher Education in Palestine
Hoe beïnvloedt de vernietiging van universiteiten in Gaza, ook wel 'scholasticide' genoemd, het wetenschappelijk leven en wat zijn de theoretische en juridische onderbouwingen van de term?
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Deep Generative Models for Engineering Design
In this thesis, we investigate how deep generative models (AI models that can create new designs) can be better utilized for technical and industrial design. Our goal is to generate designs that are not only realistic (plausible), but also efficient, reliable, and usable in complex 2D and 3D applica…
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Diversiteit en inclusie bij de Faculteit der Sociale Wetenschappen
Binnen de Faculteit der Sociale Wetenschappen (FSW) vertaalt D&I zich in de verscheidenheid aan achtergronden, perspectieven en identiteiten onder zowel studenten als medewerkers.
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Ewine van Dishoeck geeft Halley Lecture aan Oxford University
De lezing vindt plaats op woensdag 29 mei 2013 en is getiteld ‘Building stars, planets and the ingredients for life between the stars’. De Halley Lecture aan de Universiteit van Oxford is opgericht door de wijlen Henry Wilde, bij de terugkomst van de comeet Halley in 1910. De lezing wordt jaarlijks…
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Ann Wilson
Service learning
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Tessa Verhoef: 'Een algoritme kan nog veel leren van interactie tussen mensen'
Als een algoritme taal moet leren begrijpen, heeft het niets aan 'alleen maar' veel data. De computer moet het, net als wijzelf, leren in interactie met anderen. Hoe die interactie werkt, interesseert Tessa Verhoef mateloos.