367 zoekresultaten voor “lipid chris length” in de Publieke website
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Anti-Joodse beeldvorming en Jodenhaat
Van alle vormen van etnisch en raciaal vooroordeel heeft het antisemitisme verreweg de langste geschiedenis. In zijn nieuwe boek analyseert Chris Quispel het anti-semitisme over vijfentwintig eeuwen.
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Effects of lipids on DNA methylation and gene expression of immune cells implicated in atherosclerosis
Promotie
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Leeftijdsgerelateerde veranderingen in emotie herkenning tijdens de kindertijd
Nauwkeurig emoties van anderen herkennen is een essentiële sociale vaardigheid, die relevant is voor het omgaan met de sociale wereld vanaf de kindertijd. Het vermogen van kinderen om dit te doen is een mijlpaal in hun sociaal-emotionele ontwikkeling en wordt geassocieerd met een aantal belangrijke…
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Synthetic modification of fusogenic coiled-coil peptides
A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…
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Application of zebrafish and murine models in lipoprotein metabolism and atherosclerosis research
Cardiovascular diseases are still a major concern for the global health.
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Transglycosylation of N-acylethanolamines
N-acylethanolamines (NAEs), including N-arachidonoylethanolamine (anandamide, AEA), N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA), are signaling lipids that play an important role in different physiological process.
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Microglial lipid metabolism: a delicate balance
Promotie
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The evolution of shell form in tropical terrestrial microsnails
Promotor: Prof.dr. M. Schilthuizen
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Self adjuvanting immunopeptides: Design and synthesis
Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.
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Microneedle-mediated vaccine delivery
Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot
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Voormalige Teaching Fellows
De volgende docenten zijn inmiddels afgezwaaid aan de Leiden Teachers' Academy.
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Uitreiking Prof. Chris Gips Prijs
Prijsuitreiking
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Sylvestre BonnetFaculteit der Wiskunde en Natuurwetenschappen
bonnet@chem.leidenuniv.nl | 071 5274260
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Organisatie
Het Dagelijks Bestuur van de sectie bestaat uit:
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Bruggen bouwen met LEGO®-stenen: samenwerken over disciplines heen
Hoe kan de methode LEGO® Serious Play® bijdragen aan betere interdisciplinaire samenwerking en het ontwikkelen van gezamenlijke onderzoeksvoorstellen?
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Mechanisms and consequences of horizontal gene transfer in cell wall-deficient cells of Kitasatospora viridifaciens
The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…
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Chemical biology of glucosylceramide metabolism fundamental studies and applications for Gaucher disease
This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).
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Human skin equivalents for atopic dermatitis: investigating the role of filaggrin in the skin barrier
Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri
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Mast cells as immune regulators in atherosclerosis
Cardiovascular syndromes are the major cause of death in Western societies.
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The relation between dynamics and activity of phospholipase A/acyltransferase homologs
Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.
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Formulation of influenza T cell peptides: In search of a universal influenza vaccine
Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij
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Design and application of dextran based cross-linked networks
This thesis describes the design, characterization and application of dextran based crosslinked network.
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Single-cell immune profiling of atherosclerosis: from omics to therapeutics
Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…
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Innate immune modulation in atherosclerosis and vascular
Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot
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Novel analytical approaches to characterize particles in biopharmaceuticals
Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).
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Dyslipidemia, metabolism and autophagy: antigen-independent modulation of T cells in atherosclerosis
Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.
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Natural Products Lab
Wij richten ons op natuurlijke producten van onderzoek, de traditionele geneeskunde, etnobotanie en fytochemie.
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Synthetic Methodology Towards ADP-Ribosylation Related Molecular Tools
Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.
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New polymyxin antibiotics for old problems: addressing nephrotoxicity and resistance
Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…
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Intradermal delivery of nanoparticulate vaccines using coated and hollow microneedles
In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.
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Cholesterol metabolism and hematopoiesis interaction in atherothrombosis
Cardiovascular disease is the leading cause of death worldwide.
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Towards a mechanistic understanding of nanoparticle behavior using zebrafish
The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.
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Chemical tools to modulate endocannabinoid biosynthesis
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Stress-induced modulation of the innate immune system in cardiovascular disease
Promotor: Prof.dr. J. Kuiper
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Computational electrocatalysis
This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.
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Knots in plasma
A plasma is an ionized gas with very low electrical resistivity. As such, magnetic field lines are 'frozen in' and move with the fluid. Magnetic field lines that are linked, knotted and tangled, cannot be undone by the fluid motions.
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Over Psychologielab op Wielen
In Psychologielab op Wielen doen we samen met burgers innovatief onderzoek. Met ons mobiele lab rijden we naar de mensen toe in het hele land. Op straat slaan we een brug tussen wetenschap en maatschappij.
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Student Information
When you have decided to participate in a Summer School of Leiden University, there are some matters you need to know before arrival. Please take a few minutes to read through the information here to find out what you can do from your side to smooth the process.
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Searching by Learning: Exploring Artificial General Intelligence on Small Board Games by Deep Reinforcement Learning
In deep reinforcement learning, searching and learning techniques are two important components. They can be used independently and in combination to deal with different problems in AI, and have achieved impressive results in game playing and robotics. These results have inspired research into artificial…
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Professor én Ridder: Joke Bouwstra ontvangt Koninklijke Onderscheiding
Een memorabel afscheidssymposium én een koninklijke onderscheiding: mooier kon professor Joke Bouwstra haar Leidse carrière niet afsluiten. Op vrijdag 14 juni ontving zij een Koninklijke Onderscheiding uit handen van burgemeester Peter van der Velden. Hij benoemde Bouwstra tot Ridder in de Orde van…
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Investigating lipid formulations for efficient RNA delivery using zebrafish models
Promotie
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Novel strategies targeting lipid metabolism to combat sepsis
Promotie
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Zipping into Fusion
Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros
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Improvisations in phototrophy
Microbial rhodopsins are photosensitive pigments implemented in the growth and adaptation of a large population of microorganisms.
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Insecteneieren niet zo weerloos als gedacht
Insecteneieren zijn niet zo weerloos als werd gedacht. Ze hebben een beschermlaag die hen behoedt voor invloeden van buitenaf. Dit ontdekte bioloog Chris Jacobs. De antibacteriële stoffen die in deze laag worden geproduceerd, zijn mogelijk goede antibiotica. Promotie 4 december.
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Alumni aan het woord
Ontdek hoe professionals een cursus of opleiding van Universiteit Leiden Academy hebben ervaren.
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Phanta Rhei: recht en duurzaamheid
In deze bundel wordt verslag gedaan van onderzoek op het gebied van duurzaamheid, uitgevoerd aan de Leidse rechtenfaculteit.
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Citizenship, Migration and Global Transformations
Europese burgers worden geconfronteerd met uitdagingen op het gebied van globalisering, migratie, technologische ontwikkelingen en klimaatverandering. Deze uitdagingen vergen het uiterste van onderlinge internationale en intergenerationele solidariteit, wat rechtstreeks betrekking heeft op de grondslagen…
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Studieprogramma
De bacheloropleiding duurt 3 jaar. In het eerste en tweede jaar volg je zowel vakken in de scheikunde als de technologie. Daarna verdiep je je verder in één van de gebieden.
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Illuminating Host Defence against Mycobacterial Infection: Interactions with Autophagy and LC3-Associated Phagocytosis
Despite substantial progress in understanding tuberculosis (TB), the eradication of the TB epidemic is still far from reach.