Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

Extending our current arsenal of antibiotics is key to staying ahead in the arms race between humans and resistant bacteria.

How are new drugs developed? This question is central to the Minor Modern Drug Discovery (MDD), which covers the entire trajectory from disease to drug molecule and vice versa. The various research groups involved offer a complementary and interdisciplinary perspective by connecting the diverse subjects…

The formation of stars and planets happens over multiple scales, which can interact. In particular, planet formation happens in the dense, complex environment of star forming regions.

With the rise of multi-drug resistant bacterial pathogens, the possibility of a post-antibiotic world is quickly becoming reality.

In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.

Structural variants (SVs) are the hidden architecture of the human genome, and are critical for us to understand diseases, evolution, and so on.

Wat is er literair aan een grafische roman? Hoe verschilt de grafische roman van haar minder chique zusje, de strip? Welke vormen, genres en tradities kent de grafische roman? Wat is typerend voor de Nederlandse en Vlaamse grafische roman? In vier avonden reflecteren stripwetenschappers en -tekenaars…

Kunst en cultuur

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.

We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.

Soil biodiversity is of great importance for the maintenance of multifunctionality in terrestrial ecosystems.

In this Thesis, novel charge induction mechanisms of ionic liquids are treated, tested and experimented on complex oxides, in particular cuprates.

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

Promotor: A.P.IJzerman Co-promotor: A. Bender

Promotor: Prof.dr. E.J.J. Groenen, Co-Promotor: M. Huber

Promotor: H.J.A. Röttgering, Co-promotor: G.K. Miley

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

Endocannabinoids are lipid messengers that modulate various physiological functions by activating the cannabinoid CB1 and CB2 receptors. While the metabolism of endocannabinoids and their action at the CB receptors is fairly well studied, the molecular mechanisms governing their release and transport…

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

Self-assembly offers a promising route to create complex structures and materials using simple building blocks. Through, colloidal self-assembly, we can understand the governing principles of the self-assembly process and unlock its potential in diverse applications in materials science, photonics and…

Promotor: Prof.dr. G.P. van Wezel

Promotores: Prof.dr. M. Franx, Prof.dr. P.G. van Dokkum (Yale University)

We use DNA strands to stabilize few-atom silver clusters, which show unique optical and chemical properties. This thesis involves the study of these constructs for various applications.

Galaxies in the Universe are distributed along the intricate framework of the Cosmic Web. Groups and clusters of galaxies comprise the densest regions in this network, and therefore, are excellent cosmic laboratories to study different aspects of galaxy evolution in extreme environments.

Like a mixture of oil and water, lipid membranes separate into two liquid phases.

Promotie

De Universiteit Leiden en de stad Den Haag werken nauw samen om de impact van ons onderzoek en onderwijs te vergroten en zo maximaal bij te dragen aan de ontwikkeling van de stad.

De Hans Franken is een eerbetoon aan prof. dr. mr. Hans Franken, één van de oprichters van eLaw in 1985.

Over dit schilderij uit 1626 breken Rembrandtkenners zich al heel lang het hoofd. Volgens sommige interpretaties kwam de opdrachtgever uit de kringen van de universiteit. Mogelijk gaat de voorstelling over rechtspraak. Dit doek is te zien bij het Gravensteen, dat tussen 1463 en 1955 dienst deed als…

Wil jij Klinische Technologie studeren aan Universiteit Leiden en meer te weten komen over de opleiding? We laten het je zien in de opleidingsvideo.

Op deze pagina vindt u de belangrijkste informatie om te weten als ouder van een leerling die deelneemt aan de PRE-Classes.

Een overzicht van alle schrijvers die sinds 1985 gastschrijver aan de Universiteit Leiden zijn geweest.

This thesis describes the design, characterization and application of dextran based crosslinked network.

Promotores: Prof.dr. J.N. Kok, Prof.dr. M.R.V. Chaudron (Chalmers Univ., Sweden)

Understanding DNA repair mechanisms is essential for advancing plant biotechnology and crop improvement. This study investigates how double-strand breaks (DSBs), induced by CRISPR/Cas systems, are repaired in the model plant Arabidopsis thaliana, and how these processes influence Agrobacterium tumefaciens…

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

This dissertation revolves around the design and implementation of novel instrumentation and related measurement techniques, at the single molecule level, for use in biophysical research. Chapter 1 presents an introduction to the field of fluorescence-based single molecule measurements. In particular,…

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe