In deep reinforcement learning, searching and learning techniques are two important components. They can be used independently and in combination to deal with different problems in AI, and have achieved impressive results in game playing and robotics. These results have inspired research into artificial…

The research described in this thesis focused on the preparation of S/N functionalized carbene ligands and their transition metal complexes, and the exploration of their application as electrocatalysts for proton reduction.

Er is nogal wat variatie in de mate waarin parlementaire stemmingen verlopen volgens de scheidslijn regering-oppositie. Hoe zijn deze verschillen te verklaren? Party Politics artikel van Tom Louwerse et al.

Na een reeks schokken die een existentiële bedreiging vormen voor onze bestaanszekerheid, zijn onze samenlevingen steeds meer gepolariseerd geraakt. Gepolariseerde Samenlevingen Besturen (afgekort als GPS naar de Engelstalige naam Governing Polarized Societies) is een onderzoeksprogramma van onderzoekers…

This problem analysis raises the importance of a two interlinked questions: (1) what are important digital skills in the public sector? and (2) how well do different organizational and individual factors explain differences in skills levels?

Centraal in het proefschrift van Nuranisa staat de culturele diplomatie die werd beoefend door de Javaanse hoven in Midden-Java als reactie op de groeiende Nederlandse koloniale macht in de 19e en vroege 20e eeuw.

Dit onderzoek vindt plaats binnen de context van een vernieuwing in het Nederlandse biologieonderwijs. De belangrijkste doelstellingen van het onderzoek zijn (1) verhelderen hoe de praktijkkennis van docenten gerelateerd is aan de beslissingen die zij nemen wanneer zij lessen ontwerpen en uitvoeren…

In this dissertation, we work towards an experiment in which we aim to bring a micrometer sized magnet at the tip of a soft cantilever into a superposition.

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

Quantum computing is an emerging technology, which holds the potential to simulate complex quantum systems beyond the reach of classical numerical methods.Despite recent formidable advancements in quantum hardware, constructing a quantum computer capable of performing useful calculations remains challenging.In…

The idea of citizens and public professionals collaborating to provide public services has widely spread in several countries around the globe. Co-production is often presented as the go-to solution for challenges like a legitimacy crisis of both the government and the market, and financial concerns.…

The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway.

Because thin systems can deform along the thickness with relative ease, the interplay between surface mechanics and geometry plays a fundamental role in sculpting their three-dimensional shape.

In the past decade many population studies have been performed with the Atacama Large Millimeter/submillimeter Array (ALMA) to understand the bulk properties of protoplanetary disks around young stars. These population studies mostly consisted of low mass stars, with relatively few of the disks around…

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

Promotor: M.A.G.J. Orrit

Professor Barend Mons has been appointed Chair of the Commission High Level Expert Group

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

Promotor: F.J. van Lunteren, E. Jorin

Wat kunnen de talen die vandaag gesproken worden op de Kleine Soenda-eilanden ons vertellen over de geschiedenis van de verschillende bevolkingsgroepen?

The thesis explores how interstellar chemistry evolves as a function of time and changing physical architectures during the formation of stars.

In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.

To design the ideal water oxidation catalyst, understanding of the catalytic mechanism and decomposition pathways is essential.

Hoe gebruikten kustbewoners van 18e-eeuws Sri Lanka Nederlandse instellingen om hun belangen te bevorderen en hun leven vorm te geven?

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

Deze colleges zijn in het Engels, u kunt vragen stellen en reageren in het Nederlands.

Promotie

Almost three years after receiving her honorary doctorate, Dr Graça Machel returned to Leiden University. Over the course of two days she spoke with students, researchers, and other interested persons, about human rights – particularly those of women and children – in a world in which these are continually…

‘Door nieuwe technieken voor DNA-analyse op molecuulniveau slim te combineren, kunnen we doorbraken realiseren in onderzoek naar bijvoorbeeld dementie’, voorspelt hoogleraar John van Noort. Hij slaat de handen ineen met vier vooraanstaande biofysica-onderzoeksgroepen en schreef een review in Science…

Welke hersencel doet wát als bijvoorbeeld de ziekte van Parkinson ontstaat? Het duurt niet lang meer voordat die puzzel stukje voor stukje gelegd kan worden. Computationeel bioloog Ahmed Mahfouz combineert Leidse bio-kennis met Delftse algoritmen en komt steeds dichterbij de sleutel.

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

Photocatalysis has emerged as a powerful tool for enabling challenging transformations in organic synthesis. This thesis explores the development of several photocatalytic reactions designed to form carbon-heteroatom bonds from less-functionalized precursors.

Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…

This thesis combines field and laboratory studies to address some of the most pressing questions in the field of microplastic research.

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

Voor meer informatie kunt u contact opnemen met de director of verantwoordelijk hoogleraar van het Leiden Leadership Centre:

Het Instituut heeft 6 secretariaten voor de verschillende afdelingen.

This thesis describes the implementation and on-sky demonstration of high-resolution integral-field spectroscopy for extreme adaptive optics systems that are used to find and characterize exoplanets.

Bij FAIR-ASSESS zijn onderzoekers betrokken van vijf verschillende Leidse faculteiten, en experts van buiten de universiteit. Het project is opgezet door Andrei Poama en wordt geleid door Josette Daemen.

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: M.R. Hogerheijde

At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.

Promotor: J. N. Kok, Co-promotor: A. J. Knobbe

For optimization problems, it is often unclear how to choose the most appropriate optimization algorithm. As such, rigorous benchmarking practices are critical to ensure we can gain as much insight into the strengths and weaknesses of these types of algorithms.

Scattering of light in the presence of nano-structured materials, i.e. with features in the order of the wavelength of the light or smaller, reveals details of how light interacts with matter at the nanoscale.

Promotor: K. Kuijken, Co-Promotor: H. Hoekstra

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.